SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AKD_A_CAMA420_0 (CYTOCHROME P450CAM)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	5 / 11	THR S 225 LEU L 226 VAL L 227 GLY L 228 THR L 414	None FAD L 503 ( 4.8A) FAD L 503 (-3.9A) None None	1.27A	1akdA-5jfcS: undetectable	1akdA-5jfcS: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BU5_B_RBFB302_1 (PROTEIN (FLAVODOXIN))	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	4 / 8	THR L 273 THR L 251 ASP L 444 GLY S 226	None None FAD L 503 (-2.7A) FES S 501 (-3.5A)	0.91A	1bu5B-5jfcL: 4.3	1bu5B-5jfcL: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ8_A_CAMA503_0 (CYTOCHROME P450-CAM)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	5 / 9	THR S 225 LEU L 226 VAL L 227 GLY L 228 THR L 414	None FAD L 503 ( 4.8A) FAD L 503 (-3.9A) None None	1.21A	1dz8A-5jfcS: undetectable	1dz8A-5jfcS: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_1 (ESTROGEN RECEPTOR)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	THR L 168 ALA L 171 ASP L 172 LEU L 211 ILE L 206	None	1.12A	1errA-5jfcL: undetectable	1errA-5jfcL: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HTT_B_HISB450_0 (HISTIDYL-TRNA SYNTHETASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLU L 210 THR L 92 LEU L 214 GLY L 166 GLY L 459	None	1.23A	1httB-5jfcL: 3.2	1httB-5jfcL: 22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KI7_A_ID2A1_0 (THYMIDINE KINASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	5 / 12	GLU S 14 ILE S 67 ALA S 117 ARG S 12 GLU S 24	None	1.42A	1ki7A-5jfcS: undetectable	1ki7A-5jfcS: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KNY_B_KANB559_1 (KANAMYCIN NUCLEOTIDYLTRANSFERA SE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 8	GLU L 13 ASP L 307 GLU L 335 GLU L 342	None FAD L 503 (-4.4A) None None	1.14A	1knyA-5jfcL: undetectable 1knyB-5jfcL: undetectable	1knyA-5jfcL: 21.04 1knyB-5jfcL: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_B_SAMB301_0 (HEMK PROTEIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 245 GLY L 246 GLY L 163 ILE L 159 ALA L 455	None None FAD L 503 (-3.2A) None FAD L 503 (-3.5A)	0.91A	1nv8B-5jfcL: 4.0	1nv8B-5jfcL: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OPJ_A_STIA3_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 5	TYR L 323 VAL L 260 ILE L 367 MET L 372	None	1.38A	1opjA-5jfcL: undetectable	1opjA-5jfcL: 17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P91_A_SAMA1401_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE A)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 11	LEU L 4 GLY L 114 GLY L 117 ILE L 120 PRO L 63	None None None SF4 L 502 ( 4.2A) SF4 L 502 ( 4.4A)	1.13A	1p91A-5jfcL: undetectable	1p91A-5jfcL: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SDT_B_MK1B902_1 (PROTEASE RETROPEPSIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 10	ILE L 122 GLY L 123 GLY L 98 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.2A) SF4 L 501 ( 4.5A) None SF4 L 501 ( 4.4A)	0.84A	1sdtA-5jfcL: undetectable	1sdtA-5jfcL: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SDT_B_MK1B902_1 (PROTEASE RETROPEPSIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 10	ILE L 122 GLY L 123 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.2A) None None SF4 L 501 ( 4.4A)	0.98A	1sdtA-5jfcL: undetectable	1sdtA-5jfcL: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_B_SAMB302_0 (HEMK PROTEIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 245 GLY L 246 GLY L 163 ILE L 159 ALA L 455	None None FAD L 503 (-3.2A) None FAD L 503 (-3.5A)	0.94A	1sg9B-5jfcL: 2.8	1sg9B-5jfcL: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SS4_A_ACTA411_0 (GLYOXALASE FAMILY PROTEIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	4 / 5	VAL S 239 THR S 234 GLN S 258 ILE L 265	None	1.32A	1ss4A-5jfcS: undetectable	1ss4A-5jfcS: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VQ1_B_SAMB301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 245 GLY L 246 GLY L 163 ILE L 159 ALA L 455	None None FAD L 503 (-3.2A) None FAD L 503 (-3.5A)	0.97A	1vq1B-5jfcL: 2.7	1vq1B-5jfcL: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y4L_B_SVRB301_1 (PHOSPHOLIPASE A2 HOMOLOG 2)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	LEU L 412 GLY L 250 GLY L 248 GLY L 443 ARG L 447	None None FAD L 503 (-3.1A) FAD L 503 (-3.3A) None	1.20A	1y4lA-5jfcL: undetectable	1y4lA-5jfcL: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLU L 141 GLY L 137 ARG L 134 ALA L 133 ALA L 130	None	1.17A	2br4B-5jfcL: 2.9	2br4B-5jfcL: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_B_SAMB500_1 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	4 / 6	THR L 232 THR L 230 THR S 225 ASP S 245	None	1.28A	2okcB-5jfcL: undetectable	2okcB-5jfcL: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PLW_A_SAMA203_0 (RIBOSOMAL RNA METHYLTRANSFERASE, PUTATIVE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	5 / 12	PRO S 36 GLY S 37 GLU S 24 ILE S 25 ALA S 31	None	1.08A	2plwA-5jfcS: 5.8	2plwA-5jfcS: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PXC_A_SAMA500_0 (GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN) ENVELOPE PROTEIN M (MATRIX PROTEIN) MAJOR ENVELOPE PROTEIN E NON-STRUCTURAL PROTEIN 1 (NS1) NON-STRUCTURAL PROTEIN 2A (NS2A) FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT NON-STRUCTURAL PROTEIN 4A (NS4A) NON-STRUCTURAL PROTEIN 4B (NS4B) RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48) (NS5)])	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	6 / 12	GLY L 163 GLY L 457 GLY L 459 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None None SF4 L 501 ( 4.4A)	1.49A	2pxcA-5jfcL: 3.9	2pxcA-5jfcL: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_A_ACTA142_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 5	GLU L 184 PRO L 189 ILE L 194 GLY L 191	FAD L 503 (-2.1A) None None FAD L 503 (-2.6A)	1.17A	2qeuA-5jfcL: undetectable 2qeuC-5jfcL: undetectable	2qeuA-5jfcL: 16.59 2qeuC-5jfcL: 16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_1 (BETA-1 ADRENERGIC RECEPTOR)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	5 / 12	LEU S 16 THR S 66 ASP S 57 SER S 61 TYR S 120	None	1.44A	2y00B-5jfcS: undetectable	2y00B-5jfcS: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D1Z_B_017B201_1 (HIV-1 PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.03A	3d1zA-5jfcL: undetectable	3d1zA-5jfcL: 13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EIG_A_MTXA200_1 (DIHYDROFOLATE REDUCTASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 453 GLU L 126 GLU L 210 PRO L 203 LEU L 193	SF4 L 501 ( 4.4A) SF4 L 501 (-2.3A) None None None	1.29A	3eigA-5jfcL: undetectable	3eigA-5jfcL: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKT_B_017B200_2 (PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ALA L 242 ASP L 241 ILE L 182 ALA L 463 ILE L 466	None	1.09A	3ektB-5jfcL: undetectable	3ektB-5jfcL: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKY_A_DR7A100_2 (PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.14A	3ekyB-5jfcL: undetectable	3ekyB-5jfcL: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_2 (PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	6 / 10	ILE L 122 GLY L 123 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.2A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.09A	3em4V-5jfcL: undetectable	3em4V-5jfcL: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EMB_A_SAMA4633_0 (METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 457 GLY L 459 GLY L 166 VAL L 58	None	0.92A	3embA-5jfcL: 3.8	3embA-5jfcL: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1102_0 (STRUCTURAL PROTEIN VP3)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ILE L 245 GLY L 246 ALA L 455 ALA L 162 ALA L 249	None None FAD L 503 (-3.5A) None None	0.96A	3jb2A-5jfcL: 3.9	3jb2A-5jfcL: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N3I_A_ROCA201_2 (PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	4 / 6	ILE L 400 ILE L 194 GLY L 196 VAL S 222	None None FAD L 503 ( 4.3A) FES S 501 (-4.9A)	0.88A	3n3iA-5jfcL: undetectable	3n3iA-5jfcL: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NUO_B_478B478_1 (PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.05A	3nuoA-5jfcL: undetectable	3nuoA-5jfcL: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_0 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ALA L 249 GLY L 442 GLY L 246 ILE L 245 LEU L 432	None	1.02A	3o7wA-5jfcL: undetectable	3o7wA-5jfcL: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_B_478B200_2 (HIV-1 PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 10	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.04A	3oxvB-5jfcL: undetectable	3oxvB-5jfcL: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_C_478C200_2 (HIV-1 PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 11	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.07A	3oxvD-5jfcL: undetectable	3oxvD-5jfcL: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_C_478C200_2 (HIV-1 PROTEASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 11	ILE L 122 VAL L 100 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) FAD L 503 (-3.9A) None None SF4 L 501 ( 4.4A)	0.99A	3oxvD-5jfcL: undetectable	3oxvD-5jfcL: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_D_ACTD4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 5	LEU L 93 LEU L 167 GLY L 166 GLY L 163	None None None FAD L 503 (-3.2A)	0.78A	3si7C-5jfcL: undetectable 3si7D-5jfcL: undetectable	3si7C-5jfcL: 21.34 3si7D-5jfcL: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_C_SAMC300_0 (PUTATIVE METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	5 / 12	GLN S 70 GLY S 115 GLY S 113 SER S 216 ALA S 117	None None None FAD S 500 ( 4.7A) None	1.43A	3t7sC-5jfcS: 5.3	3t7sC-5jfcS: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7V_A_SAMA992_0 (METHYLORNITHINE SYNTHASE PYLB)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	5 / 12	THR S 173 GLY S 111 GLY S 113 VAL S 202 ALA S 203	None	1.18A	3t7vA-5jfcS: undetectable	3t7vA-5jfcS: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	LEU L 432 GLY L 246 ILE L 426 ILE L 159 ALA L 165	None None None None FAD L 503 (-3.6A)	1.15A	3uj7A-5jfcL: undetectable	3uj7A-5jfcL: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 248 ILE L 446 PHE L 244 ALA L 162	None FAD L 503 (-3.1A) None None None	0.91A	4a6dA-5jfcL: undetectable	4a6dA-5jfcL: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 248 ILE L 446 PHE L 244 ALA L 162	None FAD L 503 (-3.1A) None None None	0.92A	4a6eA-5jfcL: 3.2	4a6eA-5jfcL: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DC3_A_ADNA401_2 (ADENOSINE KINASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 4	LEU L 226 ILE L 160 GLY L 228 PHE L 411	FAD L 503 ( 4.8A) None None FAD L 503 (-3.4A)	1.10A	4dc3A-5jfcL: 4.5	4dc3A-5jfcL: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DF3_A_SAMA301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 166 ALA L 170 ALA L 463 ASP L 458 ALA L 455	None None None None FAD L 503 (-3.5A)	1.24A	4df3A-5jfcL: undetectable	4df3A-5jfcL: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DF3_B_SAMB301_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 166 ALA L 170 ALA L 463 ASP L 458 ALA L 455	None None None None FAD L 503 (-3.5A)	1.29A	4df3B-5jfcL: 4.3	4df3B-5jfcL: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G5J_A_0WMA1102_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 7	TYR L 132 HIS L 136 ILE L 138 PRO L 76	None	0.80A	4g5jA-5jfcL: undetectable	4g5jA-5jfcL: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HDL_A_DXCA75_0 (PPCA)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 8	ILE L 426 ILE L 243 PHE L 244 GLY L 166	None	0.83A	4hdlA-5jfcL: undetectable	4hdlA-5jfcL: 9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L3G_F_ACTF401_0 (METHYLAMINE DEHYDROGENASE HEAVY CHAIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	3 / 3	ARG L 37 LEU L 34 GLU L 38	None	0.71A	4l3gF-5jfcL: undetectable	4l3gF-5jfcL: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_A_3CJA607_1 (LACTOPEROXIDASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	3 / 3	GLN L 188 HIS L 187 ARG S 50	None	0.79A	4qyqA-5jfcL: undetectable	4qyqA-5jfcL: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_B_3CJB607_1 (LACTOPEROXIDASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	3 / 3	GLN L 188 HIS L 187 ARG S 50	None	0.81A	4qyqB-5jfcL: undetectable	4qyqB-5jfcL: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U9U_A_ACTA1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 5	GLY L 109 ALA L 110 GLY L 114 PRO L 119	None	0.79A	4u9uA-5jfcL: 4.5	4u9uA-5jfcL: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U9U_B_ACTB1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 5	GLY L 109 ALA L 110 GLY L 114 PRO L 119	None	0.77A	4u9uB-5jfcL: 4.2	4u9uB-5jfcL: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNV_D_QI9D602_0 (CYTOCHROME P450 2D6)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	4 / 7	PHE L 233 LEU L 418 VAL L 439 PHE L 244	None	1.00A	4wnvD-5jfcL: undetectable	4wnvD-5jfcL: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EC8_A_SAMA301_0 (GENOME POLYPROTEIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	6 / 12	GLY L 163 GLY L 457 GLY L 459 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None None SF4 L 501 ( 4.4A)	1.50A	5ec8A-5jfcL: 4.0	5ec8A-5jfcL: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EKX_A_SAMA301_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 457 GLY L 459 GLY L 166 VAL L 58	None	0.97A	5ekxA-5jfcL: 4.0	5ekxA-5jfcL: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J6H_A_NCAA402_0 (H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, Q10 ALPHA CHAIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	3 / 3	PRO L 119 ARG L 8 GLU L 108	None	0.84A	5j6hA-5jfcL: undetectable	5j6hA-5jfcL: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQR_A_SAMA301_0 (METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 457 GLY L 459 GLY L 166 VAL L 58	None	0.92A	5kqrA-5jfcL: 3.8	5kqrA-5jfcL: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR0_A_478A101_1 (PROTEASE E35D-APV)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ILE L 122 GLY L 98 PRO L 57 VAL L 58 ILE L 60	SF4 L 501 ( 4.6A) SF4 L 501 ( 4.5A) None None SF4 L 501 ( 4.4A)	1.05A	5kr0A-5jfcL: undetectable	5kr0A-5jfcL: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR2_A_ROCA101_1 (PROTEASE PR5-SQV)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ALA L 308 ASP L 307 GLY L 300 ILE L 299 PRO L 252	None FAD L 503 (-4.4A) None None None	1.19A	5kr2A-5jfcL: undetectable	5kr2A-5jfcL: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR2_C_ROCC101_1 (PROTEASE PR5-SQV)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 9	ALA L 308 ASP L 307 GLY L 300 ILE L 299 PRO L 252	None FAD L 503 (-4.4A) None None None	1.27A	5kr2C-5jfcL: undetectable	5kr2C-5jfcL: 14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5B_A_SAMA1001_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 246 GLY L 457 GLY L 459 GLY L 166 VAL L 58	None	0.91A	5m5bA-5jfcL: 3.8	5m5bA-5jfcL: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VIM_A_SAMA301_0 (METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	6 / 12	GLY L 163 GLY L 457 GLY L 459 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None None SF4 L 501 ( 4.4A)	1.46A	5vimA-5jfcL: 3.8	5vimA-5jfcL: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VIM_A_SAMA301_0 (METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	5 / 12	GLY L 250 GLY S 229 VAL L 260 PHE L 356 ILE L 401	None FES S 501 (-3.9A) None None None	0.94A	5vimA-5jfcL: 3.8	5vimA-5jfcL: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VIM_B_SAMB301_0 (METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus; Pyrococcus furiosus)	5 / 12	GLY L 250 GLY S 229 VAL L 260 PHE L 356 ILE L 401	None FES S 501 (-3.9A) None None None	0.93A	5vimB-5jfcL: 3.8	5vimB-5jfcL: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_A_SAMA601_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 163 GLY L 457 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None SF4 L 501 ( 4.4A)	1.03A	5wz1A-5jfcL: 3.8	5wz1A-5jfcL: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_C_SAMC601_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 163 GLY L 457 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None SF4 L 501 ( 4.4A)	1.04A	5wz1C-5jfcL: 3.9	5wz1C-5jfcL: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_D_SAMD601_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 163 GLY L 457 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None SF4 L 501 ( 4.4A)	1.05A	5wz1D-5jfcL: 3.8	5wz1D-5jfcL: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_E_SAME601_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 163 GLY L 457 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None SF4 L 501 ( 4.4A)	1.04A	5wz1E-5jfcL: 3.7	5wz1E-5jfcL: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_F_SAMF601_0 (NS5 METHYLTRANSFERASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	GLY L 163 GLY L 457 GLY L 166 VAL L 58 ILE L 453	FAD L 503 (-3.2A) None None None SF4 L 501 ( 4.4A)	1.03A	5wz1F-5jfcL: 3.9	5wz1F-5jfcL: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXI_A_LSNA502_1 (CYTOCHROME P450 2C9)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	4 / 6	GLY S 105 THR S 106 ASN S 131 LYS S 127	None	1.10A	5xxiA-5jfcS: undetectable	5xxiA-5jfcS: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6J_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	3 / 3	MET L 456 ASP L 172 ARG L 89	None	1.21A	5z6jA-5jfcL: undetectable	5z6jA-5jfcL: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Y_D_9CRD501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	3 / 3	ASN L 303 VAL L 26 HIS L 339	FAD L 503 (-3.7A) None None	0.78A	6a5yD-5jfcL: undetectable	6a5yD-5jfcL: 11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA (Pyrococcus furiosus)	4 / 4	ILE S 136 LEU S 151 HIS S 191 ALA S 123	None	1.02A	6ck2C-5jfcS: undetectable 6ck2D-5jfcS: undetectable	6ck2C-5jfcS: 4.89 6ck2D-5jfcS: 7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_A_QPSA602_1 (-)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ASP L 140 ASP L 131 GLU L 199 PRO L 203 GLY L 24	None	1.37A	6gnfA-5jfcL: 3.6	6gnfA-5jfcL: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_C_QPSC602_2 (-)	5jfc	NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA (Pyrococcus furiosus)	5 / 12	ASP L 140 ASP L 131 GLU L 199 PRO L 203 GLY L 24	None	1.35A	6gnfC-5jfcL: undetectable	6gnfC-5jfcL: 22.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AKD_A_CAMA420_0","CYTOCHROME P450CAM","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",5,"THR S 225;LEU L 226;VAL L 227;GLY L 228;THR L 414","None;FAD L 503 ( 4.8A);FAD L 503 (-3.9A);None;None","1.27A","1akdA-5jfcS:undetectable","1akdA-5jfcS:21.78"],["1BU5_B_RBFB302_1","PROTEIN (FLAVODOXIN)","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",4,"THR L 273;THR L 251;ASP L 444;GLY S 226","None;None;FAD L 503 (-2.7A);FES S 501 (-3.5A)","0.91A","1bu5B-5jfcL:4.3","1bu5B-5jfcL:16.06"],["1DZ8_A_CAMA503_0","CYTOCHROME P450-CAM","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",5,"THR S 225;LEU L 226;VAL L 227;GLY L 228;THR L 414","None;FAD L 503 ( 4.8A);FAD L 503 (-3.9A);None;None","1.21A","1dz8A-5jfcS:undetectable","1dz8A-5jfcS:21.78"],["1ERR_A_RALA600_1","ESTROGEN RECEPTOR","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"THR L 168;ALA L 171;ASP L 172;LEU L 211;ILE L 206","None","1.12A","1errA-5jfcL:undetectable","1errA-5jfcL:19.33"],["1HTT_B_HISB450_0","HISTIDYL-TRNA SYNTHETASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLU L 210;THR L  92;LEU L 214;GLY L 166;GLY L 459","None","1.23A","1httB-5jfcL:3.2","1httB-5jfcL:22.02"],["1KI7_A_ID2A1_0","THYMIDINE KINASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",5,"GLU S  14;ILE S  67;ALA S 117;ARG S  12;GLU S  24","None","1.42A","1ki7A-5jfcS:undetectable","1ki7A-5jfcS:20.29"],["1KNY_B_KANB559_1","KANAMYCIN NUCLEOTIDYLTRANSFERASE;KANAMYCIN NUCLEOTIDYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"GLU L  13;ASP L 307;GLU L 335;GLU L 342","None;FAD L 503 (-4.4A);None;None","1.14A","1knyA-5jfcL:undetectable;1knyB-5jfcL:undetectable","1knyA-5jfcL:21.04;1knyB-5jfcL:21.04"],["1NV8_B_SAMB301_0","HEMK PROTEIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 245;GLY L 246;GLY L 163;ILE L 159;ALA L 455","None;None;FAD L 503 (-3.2A);None;FAD L 503 (-3.5A)","0.91A","1nv8B-5jfcL:4.0","1nv8B-5jfcL:20.74"],["1OPJ_A_STIA3_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"TYR L 323;VAL L 260;ILE L 367;MET L 372","None","1.38A","1opjA-5jfcL:undetectable","1opjA-5jfcL:17.88"],["1P91_A_SAMA1401_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE A","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"LEU L   4;GLY L 114;GLY L 117;ILE L 120;PRO L  63","None;None;None;SF4 L 502 ( 4.2A);SF4 L 502 ( 4.4A)","1.13A","1p91A-5jfcL:undetectable","1p91A-5jfcL:19.33"],["1SDT_B_MK1B902_1","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L 123;GLY L  98;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.2A);SF4 L 501 ( 4.5A);None;SF4 L 501 ( 4.4A)","0.84A","1sdtA-5jfcL:undetectable","1sdtA-5jfcL:13.98"],["1SDT_B_MK1B902_1","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L 123;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.2A);None;None;SF4 L 501 ( 4.4A)","0.98A","1sdtA-5jfcL:undetectable","1sdtA-5jfcL:13.98"],["1SG9_B_SAMB302_0","HEMK PROTEIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 245;GLY L 246;GLY L 163;ILE L 159;ALA L 455","None;None;FAD L 503 (-3.2A);None;FAD L 503 (-3.5A)","0.94A","1sg9B-5jfcL:2.8","1sg9B-5jfcL:21.15"],["1SS4_A_ACTA411_0","GLYOXALASE FAMILY PROTEIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",4,"VAL S 239;THR S 234;GLN S 258;ILE L 265","None","1.32A","1ss4A-5jfcS:undetectable","1ss4A-5jfcS:21.18"],["1VQ1_B_SAMB301_0","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 245;GLY L 246;GLY L 163;ILE L 159;ALA L 455","None;None;FAD L 503 (-3.2A);None;FAD L 503 (-3.5A)","0.97A","1vq1B-5jfcL:2.7","1vq1B-5jfcL:21.77"],["1Y4L_B_SVRB301_1","PHOSPHOLIPASE A2 HOMOLOG 2;PHOSPHOLIPASE A2 HOMOLOG 2","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"LEU L 412;GLY L 250;GLY L 248;GLY L 443;ARG L 447","None;None;FAD L 503 (-3.1A);FAD L 503 (-3.3A);None","1.20A","1y4lA-5jfcL:undetectable","1y4lA-5jfcL:13.94"],["2BR4_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLU L 141;GLY L 137;ARG L 134;ALA L 133;ALA L 130","None","1.17A","2br4B-5jfcL:2.9","2br4B-5jfcL:20.55"],["2OKC_B_SAMB500_1","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",4,"THR L 232;THR L 230;THR S 225;ASP S 245","None","1.28A","2okcB-5jfcL:undetectable","2okcB-5jfcL:21.70"],["2PLW_A_SAMA203_0","RIBOSOMAL RNA METHYLTRANSFERASE, PUTATIVE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",5,"PRO S  36;GLY S  37;GLU S  24;ILE S  25;ALA S  31","None","1.08A","2plwA-5jfcS:5.8","2plwA-5jfcS:20.75"],["2PXC_A_SAMA500_0","GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN); ENVELOPE PROTEIN M (MATRIX PROTEIN); MAJOR ENVELOPE PROTEIN E; NON-STRUCTURAL PROTEIN 1 (NS1); NON-STRUCTURAL PROTEIN 2A (NS2A); FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT; FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT; NON-STRUCTURAL PROTEIN 4A (NS4A); NON-STRUCTURAL PROTEIN 4B (NS4B); RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48) (NS5)]","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",6,"GLY L 163;GLY L 457;GLY L 459;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;None;SF4 L 501 ( 4.4A)","1.49A","2pxcA-5jfcL:3.9","2pxcA-5jfcL:21.07"],["2QEU_A_ACTA142_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"GLU L 184;PRO L 189;ILE L 194;GLY L 191","FAD L 503 (-2.1A);None;None;FAD L 503 (-2.6A)","1.17A","2qeuA-5jfcL:undetectable;2qeuC-5jfcL:undetectable","2qeuA-5jfcL:16.59;2qeuC-5jfcL:16.59"],["2Y00_B_Y00B601_1","BETA-1 ADRENERGIC RECEPTOR","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",5,"LEU S  16;THR S  66;ASP S  57;SER S  61;TYR S 120","None","1.44A","2y00B-5jfcS:undetectable","2y00B-5jfcS:22.35"],["3D1Z_B_017B201_1","HIV-1 PROTEASE;HIV-1 PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.03A","3d1zA-5jfcL:undetectable","3d1zA-5jfcL:13.98"],["3EIG_A_MTXA200_1","DIHYDROFOLATE REDUCTASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 453;GLU L 126;GLU L 210;PRO L 203;LEU L 193","SF4 L 501 ( 4.4A);SF4 L 501 (-2.3A);None;None;None","1.29A","3eigA-5jfcL:undetectable","3eigA-5jfcL:18.08"],["3EKT_B_017B200_2","PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ALA L 242;ASP L 241;ILE L 182;ALA L 463;ILE L 466","None","1.09A","3ektB-5jfcL:undetectable","3ektB-5jfcL:16.04"],["3EKY_A_DR7A100_2","PROTEASE;PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.14A","3ekyB-5jfcL:undetectable","3ekyB-5jfcL:13.11"],["3EM4_V_DR7V100_2","PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",6,"ILE L 122;GLY L 123;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.2A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.09A","3em4V-5jfcL:undetectable","3em4V-5jfcL:12.86"],["3EMB_A_SAMA4633_0","METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 457;GLY L 459;GLY L 166;VAL L  58","None","0.92A","3embA-5jfcL:3.8","3embA-5jfcL:undetectable"],["3JB2_A_SAMA1102_0","STRUCTURAL PROTEIN VP3","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 245;GLY L 246;ALA L 455;ALA L 162;ALA L 249","None;None;FAD L 503 (-3.5A);None;None","0.96A","3jb2A-5jfcL:3.9","3jb2A-5jfcL:18.55"],["3N3I_A_ROCA201_2","PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",4,"ILE L 400;ILE L 194;GLY L 196;VAL S 222","None;None;FAD L 503 ( 4.3A);FES S 501 (-4.9A)","0.88A","3n3iA-5jfcL:undetectable","3n3iA-5jfcL:19.67"],["3NUO_B_478B478_1","PROTEASE;PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.05A","3nuoA-5jfcL:undetectable","3nuoA-5jfcL:14.25"],["3O7W_A_SAMA801_0","LEUCINE CARBOXYL METHYLTRANSFERASE 1","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ALA L 249;GLY L 442;GLY L 246;ILE L 245;LEU L 432","None","1.02A","3o7wA-5jfcL:undetectable","3o7wA-5jfcL:20.34"],["3OXV_B_478B200_2","HIV-1 PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.04A","3oxvB-5jfcL:undetectable","3oxvB-5jfcL:13.11"],["3OXV_C_478C200_2","HIV-1 PROTEASE;HIV-1 PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.07A","3oxvD-5jfcL:undetectable","3oxvD-5jfcL:13.11"],["3OXV_C_478C200_2","HIV-1 PROTEASE;HIV-1 PROTEASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;VAL L 100;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);FAD L 503 (-3.9A);None;None;SF4 L 501 ( 4.4A)","0.99A","3oxvD-5jfcL:undetectable","3oxvD-5jfcL:13.11"],["3SI7_D_ACTD4_0","CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"LEU L  93;LEU L 167;GLY L 166;GLY L 163","None;None;None;FAD L 503 (-3.2A)","0.78A","3si7C-5jfcL:undetectable;3si7D-5jfcL:undetectable","3si7C-5jfcL:21.34;3si7D-5jfcL:21.34"],["3T7S_C_SAMC300_0","PUTATIVE METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",5,"GLN S  70;GLY S 115;GLY S 113;SER S 216;ALA S 117","None;None;None;FAD S 500 ( 4.7A);None","1.43A","3t7sC-5jfcS:5.3","3t7sC-5jfcS:23.93"],["3T7V_A_SAMA992_0","METHYLORNITHINE SYNTHASE PYLB","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",5,"THR S 173;GLY S 111;GLY S 113;VAL S 202;ALA S 203","None","1.18A","3t7vA-5jfcS:undetectable","3t7vA-5jfcS:22.55"],["3UJ7_A_SAMA301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"LEU L 432;GLY L 246;ILE L 426;ILE L 159;ALA L 165","None;None;None;None;FAD L 503 (-3.6A)","1.15A","3uj7A-5jfcL:undetectable","3uj7A-5jfcL:20.65"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 248;ILE L 446;PHE L 244;ALA L 162","None;FAD L 503 (-3.1A);None;None;None","0.91A","4a6dA-5jfcL:undetectable","4a6dA-5jfcL:21.19"],["4A6E_A_SAMA1349_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 248;ILE L 446;PHE L 244;ALA L 162","None;FAD L 503 (-3.1A);None;None;None","0.92A","4a6eA-5jfcL:3.2","4a6eA-5jfcL:21.19"],["4DC3_A_ADNA401_2","ADENOSINE KINASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"LEU L 226;ILE L 160;GLY L 228;PHE L 411","FAD L 503 ( 4.8A);None;None;FAD L 503 (-3.4A)","1.10A","4dc3A-5jfcL:4.5","4dc3A-5jfcL:21.67"],["4DF3_A_SAMA301_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 166;ALA L 170;ALA L 463;ASP L 458;ALA L 455","None;None;None;None;FAD L 503 (-3.5A)","1.24A","4df3A-5jfcL:undetectable","4df3A-5jfcL:21.52"],["4DF3_B_SAMB301_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 166;ALA L 170;ALA L 463;ASP L 458;ALA L 455","None;None;None;None;FAD L 503 (-3.5A)","1.29A","4df3B-5jfcL:4.3","4df3B-5jfcL:21.52"],["4G5J_A_0WMA1102_1","EPIDERMAL GROWTH FACTOR RECEPTOR","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"TYR L 132;HIS L 136;ILE L 138;PRO L  76","None","0.80A","4g5jA-5jfcL:undetectable","4g5jA-5jfcL:22.63"],["4HDL_A_DXCA75_0","PPCA","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"ILE L 426;ILE L 243;PHE L 244;GLY L 166","None","0.83A","4hdlA-5jfcL:undetectable","4hdlA-5jfcL:9.88"],["4L3G_F_ACTF401_0","METHYLAMINE DEHYDROGENASE HEAVY CHAIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",3,"ARG L  37;LEU L  34;GLU L  38","None","0.71A","4l3gF-5jfcL:undetectable","4l3gF-5jfcL:21.91"],["4QYQ_A_3CJA607_1","LACTOPEROXIDASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",3,"GLN L 188;HIS L 187;ARG S  50","None","0.79A","4qyqA-5jfcL:undetectable","4qyqA-5jfcL:22.35"],["4QYQ_B_3CJB607_1","LACTOPEROXIDASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",3,"GLN L 188;HIS L 187;ARG S  50","None","0.81A","4qyqB-5jfcL:undetectable","4qyqB-5jfcL:22.35"],["4U9U_A_ACTA1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"GLY L 109;ALA L 110;GLY L 114;PRO L 119","None","0.79A","4u9uA-5jfcL:4.5","4u9uA-5jfcL:19.31"],["4U9U_B_ACTB1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"GLY L 109;ALA L 110;GLY L 114;PRO L 119","None","0.77A","4u9uB-5jfcL:4.2","4u9uB-5jfcL:19.31"],["4WNV_D_QI9D602_0","CYTOCHROME P450 2D6","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",4,"PHE L 233;LEU L 418;VAL L 439;PHE L 244","None","1.00A","4wnvD-5jfcL:undetectable","4wnvD-5jfcL:22.82"],["5EC8_A_SAMA301_0","GENOME POLYPROTEIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",6,"GLY L 163;GLY L 457;GLY L 459;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;None;SF4 L 501 ( 4.4A)","1.50A","5ec8A-5jfcL:4.0","5ec8A-5jfcL:19.50"],["5EKX_A_SAMA301_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 457;GLY L 459;GLY L 166;VAL L  58","None","0.97A","5ekxA-5jfcL:4.0","5ekxA-5jfcL:undetectable"],["5J6H_A_NCAA402_0","H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, Q10 ALPHA CHAIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",3,"PRO L 119;ARG L   8;GLU L 108","None","0.84A","5j6hA-5jfcL:undetectable","5j6hA-5jfcL:18.92"],["5KQR_A_SAMA301_0","METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 457;GLY L 459;GLY L 166;VAL L  58","None","0.92A","5kqrA-5jfcL:3.8","5kqrA-5jfcL:20.55"],["5KR0_A_478A101_1","PROTEASE E35D-APV","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ILE L 122;GLY L  98;PRO L  57;VAL L  58;ILE L  60","SF4 L 501 ( 4.6A);SF4 L 501 ( 4.5A);None;None;SF4 L 501 ( 4.4A)","1.05A","5kr0A-5jfcL:undetectable","5kr0A-5jfcL:11.84"],["5KR2_A_ROCA101_1","PROTEASE PR5-SQV","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ALA L 308;ASP L 307;GLY L 300;ILE L 299;PRO L 252","None;FAD L 503 (-4.4A);None;None;None","1.19A","5kr2A-5jfcL:undetectable","5kr2A-5jfcL:14.92"],["5KR2_C_ROCC101_1","PROTEASE PR5-SQV","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ALA L 308;ASP L 307;GLY L 300;ILE L 299;PRO L 252","None;FAD L 503 (-4.4A);None;None;None","1.27A","5kr2C-5jfcL:undetectable","5kr2C-5jfcL:14.92"],["5M5B_A_SAMA1001_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 246;GLY L 457;GLY L 459;GLY L 166;VAL L  58","None","0.91A","5m5bA-5jfcL:3.8","5m5bA-5jfcL:20.76"],["5VIM_A_SAMA301_0","METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",6,"GLY L 163;GLY L 457;GLY L 459;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;None;SF4 L 501 ( 4.4A)","1.46A","5vimA-5jfcL:3.8","5vimA-5jfcL:21.24"],["5VIM_A_SAMA301_0","METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",5,"GLY L 250;GLY S 229;VAL L 260;PHE L 356;ILE L 401","None;FES S 501 (-3.9A);None;None;None","0.94A","5vimA-5jfcL:3.8","5vimA-5jfcL:21.24"],["5VIM_B_SAMB301_0","METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA;NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus;Pyrococcus furiosus",5,"GLY L 250;GLY S 229;VAL L 260;PHE L 356;ILE L 401","None;FES S 501 (-3.9A);None;None;None","0.93A","5vimB-5jfcL:3.8","5vimB-5jfcL:21.24"],["5WZ1_A_SAMA601_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 163;GLY L 457;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;SF4 L 501 ( 4.4A)","1.03A","5wz1A-5jfcL:3.8","5wz1A-5jfcL:20.59"],["5WZ1_C_SAMC601_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 163;GLY L 457;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;SF4 L 501 ( 4.4A)","1.04A","5wz1C-5jfcL:3.9","5wz1C-5jfcL:20.59"],["5WZ1_D_SAMD601_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 163;GLY L 457;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;SF4 L 501 ( 4.4A)","1.05A","5wz1D-5jfcL:3.8","5wz1D-5jfcL:20.59"],["5WZ1_E_SAME601_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 163;GLY L 457;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;SF4 L 501 ( 4.4A)","1.04A","5wz1E-5jfcL:3.7","5wz1E-5jfcL:20.59"],["5WZ1_F_SAMF601_0","NS5 METHYLTRANSFERASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"GLY L 163;GLY L 457;GLY L 166;VAL L  58;ILE L 453","FAD L 503 (-3.2A);None;None;None;SF4 L 501 ( 4.4A)","1.03A","5wz1F-5jfcL:3.9","5wz1F-5jfcL:20.59"],["5XXI_A_LSNA502_1","CYTOCHROME P450 2C9","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",4,"GLY S 105;THR S 106;ASN S 131;LYS S 127","None","1.10A","5xxiA-5jfcS:undetectable","5xxiA-5jfcS:21.83"],["5Z6J_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",3,"MET L 456;ASP L 172;ARG L  89","None","1.21A","5z6jA-5jfcL:undetectable","5z6jA-5jfcL:16.88"],["6A5Y_D_9CRD501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",3,"ASN L 303;VAL L  26;HIS L 339","FAD L 503 (-3.7A);None;None","0.78A","6a5yD-5jfcL:undetectable","6a5yD-5jfcL:11.14"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT BETA","Pyrococcus furiosus",4,"ILE S 136;LEU S 151;HIS S 191;ALA S 123","None","1.02A","6ck2C-5jfcS:undetectable;6ck2D-5jfcS:undetectable","6ck2C-5jfcS:4.89;6ck2D-5jfcS:7.92"],["6GNF_A_QPSA602_1","-","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ASP L 140;ASP L 131;GLU L 199;PRO L 203;GLY L  24","None","1.37A","6gnfA-5jfcL:3.6","6gnfA-5jfcL:22.97"],["6GNF_C_QPSC602_2","-","5jfc","NADH-DEPENDENT FERREDOXIN:NADP OXIDOREDUCTASE SUBUNIT ALPHA","Pyrococcus furiosus",5,"ASP L 140;ASP L 131;GLU L 199;PRO L 203;GLY L  24","None","1.35A","6gnfC-5jfcL:undetectable","6gnfC-5jfcL:22.97"]]