SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.81A 1a7yA-5jfmA:
undetectable		 1a7yA-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.71A 1a7yB-5jfmA:
undetectable		 1a7yB-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.78A 1dscC-5jfmA:
undetectable		 1dscC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.65A 1dscC-5jfmA:
undetectable		 1dscC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.89A 1fjaC-5jfmA:
undetectable		 1fjaC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.77A 1fjaC-5jfmA:
undetectable		 1fjaC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.89A 1fjaD-5jfmA:
undetectable		 1fjaD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.77A 1fjaD-5jfmA:
undetectable		 1fjaD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.88A 1i3wE-5jfmA:
undetectable		 1i3wE-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.78A 1i3wE-5jfmA:
undetectable		 1i3wE-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.78A 1i3wF-5jfmA:
undetectable		 1i3wF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.84A 1i3wG-5jfmA:
undetectable		 1i3wG-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.74A 1i3wG-5jfmA:
undetectable		 1i3wG-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.75A 1i3wH-5jfmA:
undetectable		 1i3wH-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.76A 1mnvD-5jfmA:
undetectable		 1mnvD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.70A 1mnvD-5jfmA:
undetectable		 1mnvD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 7 ALA A 387
ILE A 358
TYR A 356
ILE A 394
 None
 0.87A 1oniD-5jfmA:
undetectable
1oniF-5jfmA:
undetectable		 1oniD-5jfmA:
14.40
1oniF-5jfmA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.87A 1ovfB-5jfmA:
undetectable		 1ovfB-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.79A 1qfiA-5jfmA:
undetectable		 1qfiA-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.79A 1unjF-5jfmA:
undetectable		 1unjF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.83A 1unjF-5jfmA:
undetectable		 1unjF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.77A 1unjL-5jfmA:
undetectable		 1unjL-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.73A 1unjL-5jfmA:
undetectable		 1unjL-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.71A 1unjR-5jfmA:
undetectable		 1unjR-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.73A 1unjR-5jfmA:
undetectable		 1unjR-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 197
THR A 195
PRO A 200
 1VU  A 601 ( 4.8A)
None
None
 0.79A 1unjW-5jfmA:
undetectable		 1unjW-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.75A 1unjW-5jfmA:
undetectable		 1unjW-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.72A 1unjX-5jfmA:
undetectable		 1unjX-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.75A 1unjX-5jfmA:
undetectable		 1unjX-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.77A 1unmE-5jfmA:
undetectable		 1unmE-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.76A 1unmE-5jfmA:
undetectable		 1unmE-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.76A 1unmF-5jfmA:
undetectable		 1unmF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
THR A 203
PRO A 200
 None
 0.72A 1unmF-5jfmA:
undetectable		 1unmF-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.88A 1xwfA-5jfmA:
4.6		 1xwfA-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.88A 1xwfB-5jfmA:
4.3		 1xwfB-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.87A 1xwfC-5jfmA:
undetectable		 1xwfC-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 201
GLU A 143
HIS A 223
 None
None
1VU  A 601 (-3.9A)
 0.90A 1xwfD-5jfmA:
4.6		 1xwfD-5jfmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 274
GLY A 192
MET A 265
THR A 195
ILE A 204
 None
 1.43A 1z95A-5jfmA:
undetectable		 1z95A-5jfmA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 7 ASN A 238
GLY A  89
THR A 253
SER A 208
 None
 1.26A 2o5yH-5jfmA:
undetectable
2o5yL-5jfmA:
undetectable		 2o5yH-5jfmA:
17.73
2o5yL-5jfmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 8 ARG A 459
LYS A 463
LYS A 460
ASP A 434
 None
 0.94A 2rk8A-5jfmA:
undetectable		 2rk8A-5jfmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 7 ARG A 459
LYS A 463
LYS A 460
ASP A 434
 None
 0.92A 2rk8B-5jfmA:
undetectable		 2rk8B-5jfmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.82A 316dC-5jfmA:
undetectable		 316dC-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 278
ILE A 282
PRO A 498
THR A 499
 1VU  A 601 (-3.5A)
1VU  A 601 (-3.6A)
None
None
 0.65A 3el9A-5jfmA:
undetectable		 3el9A-5jfmA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 VAL A 303
ILE A 342
ILE A 347
LEU A 406
ILE A 336
 None
 1.11A 3hbbA-5jfmA:
2.3		 3hbbA-5jfmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 VAL A 303
ILE A 311
ILE A 347
LEU A 406
ILE A 336
 None
 1.02A 3hbbC-5jfmA:
undetectable		 3hbbC-5jfmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 9 MET A 422
LEU A 391
VAL A 371
ILE A 358
ILE A 424
 None
 1.25A 3jw3B-5jfmA:
undetectable		 3jw3B-5jfmA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 509
ALA A 193
THR A 195
ILE A 204
ILE A 127
 None
 1.24A 3ld6A-5jfmA:
undetectable		 3ld6A-5jfmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.06A 4coxA-5jfmA:
undetectable		 4coxA-5jfmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.05A 4coxB-5jfmA:
undetectable		 4coxB-5jfmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4coxD-5jfmA:
undetectable		 4coxD-5jfmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		3 / 3 THR A 203
PRO A 200
THR A 201
 None
 0.75A 4hivD-5jfmA:
undetectable		 4hivD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 274
GLY A 192
MET A 265
THR A 195
ILE A 204
 None
 1.36A 4okbA-5jfmA:
undetectable		 4okbA-5jfmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 0.99A 4otyA-5jfmA:
undetectable		 4otyA-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4otyB-5jfmA:
undetectable		 4otyB-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.30A 4qvnH-5jfmA:
undetectable
4qvnI-5jfmA:
undetectable		 4qvnH-5jfmA:
20.84
4qvnI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvnV-5jfmA:
undetectable
4qvnW-5jfmA:
undetectable		 4qvnV-5jfmA:
20.84
4qvnW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvqH-5jfmA:
undetectable
4qvqI-5jfmA:
undetectable		 4qvqH-5jfmA:
20.84
4qvqI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qvqV-5jfmA:
undetectable
4qvqW-5jfmA:
undetectable		 4qvqV-5jfmA:
20.84
4qvqW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qvwH-5jfmA:
0.0
4qvwI-5jfmA:
0.3		 4qvwH-5jfmA:
20.84
4qvwI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 10 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.27A 4qvwV-5jfmA:
undetectable
4qvwW-5jfmA:
undetectable		 4qvwV-5jfmA:
20.84
4qvwW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qw1H-5jfmA:
undetectable
4qw1I-5jfmA:
undetectable		 4qw1H-5jfmA:
20.84
4qw1I-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 4qw1V-5jfmA:
undetectable
4qw1W-5jfmA:
undetectable		 4qw1V-5jfmA:
20.84
4qw1W-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.30A 4qwuH-5jfmA:
undetectable
4qwuI-5jfmA:
undetectable		 4qwuH-5jfmA:
20.84
4qwuI-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.29A 4qwuV-5jfmA:
undetectable
4qwuW-5jfmA:
undetectable		 4qwuV-5jfmA:
20.84
4qwuW-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4rrwC-5jfmA:
0.4		 4rrwC-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4rrwD-5jfmA:
undetectable		 4rrwD-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 0.92A 4rrxA-5jfmA:
undetectable		 4rrxA-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 0.91A 4rrxB-5jfmA:
undetectable		 4rrxB-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4rrzC-5jfmA:
0.4		 4rrzC-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.04A 4rrzD-5jfmA:
undetectable		 4rrzD-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 346
ALA A 355
LYS A 351
ALA A 315
ILE A 404
 None
 1.13A 4x1iD-5jfmA:
undetectable		 4x1iD-5jfmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 7 THR A 197
MET A 146
VAL A 383
THR A 380
 1VU  A 601 ( 4.8A)
1VU  A 601 ( 4.1A)
1VU  A 601 ( 4.7A)
1VU  A 601 (-3.8A)
 1.02A 5e4dA-5jfmA:
undetectable
5e4dB-5jfmA:
undetectable		 5e4dA-5jfmA:
15.91
5e4dB-5jfmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 11 THR A 203
PRO A 196
ALA A 226
PHE A 220
GLU A 142
 None
1VU  A 601 (-4.6A)
None
None
None
 1.12A 5ewjA-5jfmA:
undetectable
5ewjB-5jfmA:
3.8		 5ewjA-5jfmA:
22.74
5ewjB-5jfmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 203
PRO A 196
ALA A 226
PHE A 220
GLU A 142
 None
1VU  A 601 (-4.6A)
None
None
None
 1.10A 5ewjC-5jfmA:
4.2
5ewjD-5jfmA:
3.8		 5ewjC-5jfmA:
22.74
5ewjD-5jfmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 483
SER A 479
VAL A 331
PRO A 329
SER A 137
 None
None
1VU  A 601 ( 4.2A)
1VU  A 601 (-4.6A)
None
 1.37A 5f9zB-5jfmA:
3.4		 5f9zB-5jfmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 ARG A 124
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 1.12A 5iktA-5jfmA:
undetectable		 5iktA-5jfmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 ARG A 124
VAL A 205
VAL A 120
GLY A 122
LEU A 128
 None
 1.01A 5iktA-5jfmA:
undetectable		 5iktA-5jfmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 THR A 201
SER A 230
THR A 197
ALA A 226
THR A 144
 None
None
1VU  A 601 ( 4.8A)
None
None
 1.28A 5l66V-5jfmA:
undetectable
5l66W-5jfmA:
undetectable		 5l66V-5jfmA:
20.84
5l66W-5jfmA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 GLU A 202
VAL A 205
THR A 492
THR A 450
HIS A 449
 None
 1.40A 5xipB-5jfmA:
undetectable		 5xipB-5jfmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5jfm ALDEHYDE
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 346
ALA A 355
LYS A 351
ALA A 315
ILE A 404
 None
 1.30A 5xiwD-5jfmA:
undetectable		 5xiwD-5jfmA:
9.64