SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		4 / 7 LEU A 233
SER A 230
ASP A 217
PHE A 254
 None
 1.15A 1ismB-5jfqA:
undetectable		 1ismB-5jfqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		5 / 12 LEU A  78
ASP A  85
GLN A 148
THR A 173
GLN A 210
 None
 0.76A 2f94F-5jfqA:
26.0		 2f94F-5jfqA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		4 / 8 ALA A 181
ALA A 185
SER A  52
ALA A  53
 None
 0.88A 2vh3B-5jfqA:
1.4		 2vh3B-5jfqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		5 / 9 ALA A 181
ILE A 177
GLY A 178
ILE A 179
HIS A  74
 None
 1.34A 2zm9A-5jfqA:
undetectable		 2zm9A-5jfqA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		4 / 4 ILE A 177
PHE A 209
GLN A 210
ASP A 213
 None
 1.26A 4umjA-5jfqA:
32.6		 4umjA-5jfqA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		4 / 6 HIS A  74
GLY A  41
GLU A  71
ARG A  43
 None
 1.03A 4zbqA-5jfqA:
undetectable		 4zbqA-5jfqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		3 / 3 ALA A 291
ASN A 294
LEU A 295
 None
 0.39A 5i1pA-5jfqA:
undetectable		 5i1pA-5jfqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		4 / 7 LEU A 120
GLU A 115
ILE A 144
VAL A  73
 None
 1.18A 5jh7C-5jfqA:
undetectable		 5jh7C-5jfqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Geoglobus
acetivorans) 		5 / 12 LEU A 176
PHE A 117
ALA A 133
ALA A  63
ILE A  64
 None
 0.99A 5veuB-5jfqA:
undetectable		 5veuB-5jfqA:
21.78