SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		5 / 12 VAL A 118
PHE A 162
THR A 143
LYS A 140
LEU A 237
 None
None
MRD  A 302 (-4.0A)
MRD  A 302 (-3.6A)
None
 1.03A 2jn3A-5jftA:
undetectable		 2jn3A-5jftA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		3 / 3 VAL A 155
LYS A 157
HIS A 108
 None
 0.90A 3elzA-5jftA:
undetectable		 3elzA-5jftA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		5 / 11 MET A 278
PHE A 280
GLY A 232
PHE A  81
GLY A  48
 None
 1.33A 3v3nA-5jftA:
3.8		 3v3nA-5jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		5 / 11 MET A 278
PHE A 280
GLY A 232
PHE A  81
GLY A  48
 None
 1.33A 3v3nD-5jftA:
3.7		 3v3nD-5jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		4 / 9 PHE A 161
CYH A 119
ILE A  99
MET A 100
 None
 1.22A 4jvlA-5jftA:
undetectable		 4jvlA-5jftA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		4 / 6 PHE A  58
PRO A  66
ARG A 212
THR A  70
 None
 1.36A 5ih0A-5jftA:
undetectable		 5ih0A-5jftA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A
(Danio
rerio) 		5 / 12 ARG A  82
ILE A  87
VAL A 106
ILE A  51
LEU A  42
 None
 0.98A 5ycnA-5jftA:
undetectable		 5ycnA-5jftA:
22.15