SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		5 / 6 LYS A  61
LYS A  62
ASP A  65
ALA A  66
LEU A  84
 None
HEM  A 201 (-3.9A)
None
HEM  A 201 ( 3.7A)
HEM  A 201 (-4.6A)
 0.54A 1iwhA-5jggA:
24.9		 1iwhA-5jggA:
59.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.7A)
None
None
HEM  A 201 (-4.0A)
 1.00A 1wmqB-5jggA:
undetectable		 1wmqB-5jggA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.7A)
None
None
HEM  A 201 (-4.0A)
 0.99A 1wrqA-5jggA:
undetectable		 1wrqA-5jggA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.7A)
None
None
HEM  A 201 (-4.0A)
 0.99A 1wrqB-5jggA:
undetectable		 1wrqB-5jggA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		5 / 10 PHE A 129
LEU A 137
HIS A  88
ILE A  77
ALA A  66
 None
None
HEM  A 201 (-3.3A)
None
HEM  A 201 ( 3.7A)
 1.05A 2bxeB-5jggA:
2.2		 2bxeB-5jggA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		5 / 12 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 HEM  A 201 ( 4.7A)
None
None
None
None
 1.19A 2j0dA-5jggA:
undetectable		 2j0dA-5jggA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		4 / 8 TYR A 113
LEU A 110
LEU A  24
ALA A  28
 None
 1.00A 2wekA-5jggA:
undetectable		 2wekA-5jggA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		5 / 11 SER A  85
VAL A 133
LEU A  81
THR A  82
HIS A 135
 None
 1.04A 4e0fA-5jggA:
undetectable		 4e0fA-5jggA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5jgg ALPHA CHAIN
(Acipenser
persicus) 		4 / 7 PHE A 129
ILE A  67
LEU A 110
TYR A 113
 None
 0.86A 5h3aB-5jggA:
undetectable		 5h3aB-5jggA:
21.35