SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		4 / 6 LEU A 142
ILE A 110
ASP A  88
PRO A  90
 None
 1.01A 1ditH-5jh1A:
undetectable
1ditP-5jh1A:
undetectable		 1ditH-5jh1A:
21.86
1ditP-5jh1A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		4 / 4 VAL A 249
PHE A   5
SER A  15
VAL A  16
 None
 1.14A 1e7cA-5jh1A:
undetectable		 1e7cA-5jh1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 PHE A  74
THR A   9
THR A  76
VAL A 174
GLY A 152
 None
 1.25A 2a1nA-5jh1A:
undetectable		 2a1nA-5jh1A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		3 / 3 LYS A 147
ASP A  99
ASN A  94
 None
 1.14A 2bm9A-5jh1A:
undetectable		 2bm9A-5jh1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		4 / 4 VAL A 249
LEU A 230
ILE A 226
LEU A 275
 None
 0.95A 2byoA-5jh1A:
undetectable		 2byoA-5jh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 10 PHE A  74
THR A   9
THR A  76
VAL A 174
GLY A 152
 None
 1.29A 2cp4A-5jh1A:
undetectable		 2cp4A-5jh1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 LEU A  62
LEU A  59
LEU A 100
THR A  76
VAL A  28
 None
 1.19A 2qd3A-5jh1A:
undetectable		 2qd3A-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		4 / 7 GLY A 137
ALA A 138
MET A 139
LEU A 142
 None
 0.61A 2wekB-5jh1A:
2.0		 2wekB-5jh1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 PRO A  14
ILE A  43
LEU A  18
ALA A  31
LEU A  62
 None
 1.19A 3a50A-5jh1A:
undetectable		 3a50A-5jh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 ILE A 223
GLN A 283
THR A 211
VAL A 177
LEU A 188
 None
 1.30A 3em0B-5jh1A:
undetectable		 3em0B-5jh1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		3 / 3 SER A 157
PHE A 191
LYS A 187
 None
 0.77A 3u88A-5jh1A:
undetectable		 3u88A-5jh1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 LEU A  62
LEU A  59
LEU A 100
THR A  76
VAL A  28
 None
 1.24A 4f4dA-5jh1A:
undetectable		 4f4dA-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 LEU A  62
LEU A  59
LEU A 100
SER A  77
THR A  76
 None
 1.08A 4f4dB-5jh1A:
undetectable		 4f4dB-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 LEU A  62
LEU A 100
SER A  77
THR A  76
VAL A  28
 None
 1.23A 4f4dB-5jh1A:
undetectable		 4f4dB-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		3 / 3 ASP A 106
ARG A 149
ASP A  72
 None
 0.88A 4fzvA-5jh1A:
undetectable		 4fzvA-5jh1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		4 / 8 SER A 154
ALA A  46
ASP A  44
SER A  20
 None
 1.11A 5l5fY-5jh1A:
undetectable
5l5fZ-5jh1A:
undetectable		 5l5fY-5jh1A:
24.36
5l5fZ-5jh1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 HIS A  42
ILE A  13
VAL A 177
HIS A 198
ASP A 175
 None
 1.48A 5z0fA-5jh1A:
undetectable
5z0fB-5jh1A:
undetectable		 5z0fA-5jh1A:
13.96
5z0fB-5jh1A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 HIS A  42
ILE A  13
VAL A 177
HIS A 198
ASP A 175
 None
 1.42A 5z0gA-5jh1A:
undetectable
5z0gB-5jh1A:
undetectable		 5z0gA-5jh1A:
13.96
5z0gB-5jh1A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 HIS A  42
ILE A  13
VAL A 177
HIS A 198
ASP A 175
 None
 1.48A 5z0jA-5jh1A:
undetectable
5z0jB-5jh1A:
undetectable		 5z0jA-5jh1A:
13.96
5z0jB-5jh1A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 11 HIS A  42
ILE A  13
VAL A 177
HIS A 198
ASP A 175
 None
 1.42A 5z0mA-5jh1A:
undetectable
5z0mB-5jh1A:
undetectable		 5z0mA-5jh1A:
13.96
5z0mB-5jh1A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		3 / 3 ASP A 106
ARG A 149
ASP A  72
 None
 0.79A 5zvgA-5jh1A:
undetectable		 5zvgA-5jh1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		3 / 3 ASP A 106
ARG A 149
ASP A  72
 None
 0.79A 5zvgB-5jh1A:
undetectable		 5zvgB-5jh1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5jh1 ALDOSE REDUCTASE,
AKR4C7
(Zea
mays) 		5 / 12 LEU A 250
ILE A  43
LEU A 100
ARG A  47
LEU A 109
 None
 1.33A 6ie8A-5jh1A:
undetectable		 6ie8A-5jh1A:
20.06