SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5jh5 POLYCOMB GROUP RING
FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU C 248
LEU C 169
MET C 231
VAL C 200
LEU C 227
 None
 1.38A 2q7kA-5jh5C:
undetectable		 2q7kA-5jh5C:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 12 ASP A1179
LEU A1178
SER A1229
ILE A1233
LEU A1240
 None
 1.13A 4qi9B-5jh5A:
undetectable		 4qi9B-5jh5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		4 / 4 ASN A1108
VAL A1155
THR A1134
ILE A1136
 None
 1.49A 4retA-5jh5A:
undetectable		 4retA-5jh5A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		4 / 4 ASN A1108
VAL A1155
THR A1134
ILE A1136
 None
 1.48A 4retC-5jh5A:
undetectable		 4retC-5jh5A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 12 SER A1255
LEU A1220
ASP A1227
ILE A1225
LEU A1259
 None
 1.12A 4y8wB-5jh5A:
undetectable		 4y8wB-5jh5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 9 ARG A1219
LEU A1218
LEU A1186
ILE A1225
ALA A1221
 None
 1.09A 4z69A-5jh5A:
undetectable		 4z69A-5jh5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 12 VAL A1281
ILE A1273
LEU A1245
LEU A1230
VAL A1251
 None
 1.27A 5im2A-5jh5A:
undetectable		 5im2A-5jh5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 12 VAL A1180
ASP A1179
ASP A1224
ARG A1219
LEU A1243
 None
 1.26A 5syfB-5jh5A:
undetectable		 5syfB-5jh5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5jh5 POLYCOMB GROUP RING
FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU C 250
LEU C 203
ALA C 198
LEU C 171
ARG C 240
 None
 0.91A 6b0cD-5jh5C:
undetectable		 6b0cD-5jh5C:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B
(Homo
sapiens) 		5 / 11 MET A1237
LEU A1270
LEU A1218
ILE A1225
MET A1191
 None
 1.34A 6fgcA-5jh5A:
undetectable		 6fgcA-5jh5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5jh5 POLYCOMB GROUP RING
FINGER PROTEIN 1
(Homo
sapiens) 		4 / 5 SER C 253
VAL C 254
LYS C 255
PRO C 215
 None
 1.25A 6fi4A-5jh5C:
undetectable
6fi4B-5jh5C:
undetectable		 6fi4A-5jh5C:
19.42
6fi4B-5jh5C:
4.81