SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 8 ASP A 109
ASP A  29
TYR A 176
TYR A 295
 HIS  A 505 (-2.3A)
HIS  A 505 ( 4.5A)
6KY  A 504 (-4.0A)
6KY  A 504 (-3.4A)
 1.43A 1ceaA-5jh8A:
undetectable
1ceaB-5jh8A:
undetectable		 1ceaA-5jh8A:
12.70
1ceaB-5jh8A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 TYR A   5
ASP A 109
MET A 174
TYR A 176
ASP A 177
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
 0.78A 1e9lA-5jh8A:
32.5		 1e9lA-5jh8A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 7 THR A  84
SER A  85
TYR A 159
LEU A 164
 None
 1.10A 1ibgL-5jh8A:
undetectable		 1ibgL-5jh8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 211
TYR A 170
VAL A   2
GLY A 291
ALA A   0
 None
 1.11A 1pxxA-5jh8A:
undetectable		 1pxxA-5jh8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 LEU A 211
TYR A 170
VAL A   2
GLY A 291
ALA A   0
 None
 1.12A 1pxxB-5jh8A:
undetectable		 1pxxB-5jh8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 211
TYR A 170
VAL A   2
GLY A 291
ALA A   0
 None
 1.12A 1pxxD-5jh8A:
undetectable		 1pxxD-5jh8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 GLY A 190
ASP A 197
ILE A 173
GLY A 213
ILE A 214
 None
 0.98A 1t3rA-5jh8A:
undetectable		 1t3rA-5jh8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 GLY A 190
ASP A 197
ILE A 173
GLY A 213
ILE A 214
 None
 0.99A 1t7iA-5jh8A:
undetectable		 1t7iA-5jh8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.01A 1udtA-5jh8A:
undetectable		 1udtA-5jh8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  98
TYR A  62
ILE A 106
ASP A 169
 None
MLZ  A 138 ( 4.1A)
None
MLZ  A 138 ( 2.7A)
 1.05A 1upfA-5jh8A:
undetectable		 1upfA-5jh8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ALA A 207
TYR A 287
ILE A 210
ASP A 199
 None
 1.23A 1upfA-5jh8A:
undetectable		 1upfA-5jh8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ALA A 207
TYR A 287
ILE A 210
ASP A 199
 None
 1.18A 1upfC-5jh8A:
2.1		 1upfC-5jh8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.03A 1xp0A-5jh8A:
undetectable		 1xp0A-5jh8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.50A 2a3aA-5jh8A:
31.2		 2a3aA-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.52A 2a3aB-5jh8A:
31.6		 2a3aB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ASP A 109
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.89A 2a3bB-5jh8A:
31.5		 2a3bB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.03A 2h42B-5jh8A:
undetectable		 2h42B-5jh8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.59A 3g6mA-5jh8A:
31.8		 3g6mA-5jh8A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 4 ARG A 223
ASP A 177
GLY A 218
THR A 268
 None
6KY  A 504 (-2.6A)
None
None
 1.34A 3k4vB-5jh8A:
undetectable		 3k4vB-5jh8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 11 ASN A  93
VAL A  82
ALA A  81
THR A  34
ILE A  78
 None
 1.14A 3n23A-5jh8A:
undetectable		 3n23A-5jh8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ILE A  78
VAL A  68
PHE A 110
ILE A 106
ILE A  33
 None
 1.25A 3um5B-5jh8A:
undetectable		 3um5B-5jh8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 GLN A  87
PHE A 121
HIS A 123
ALA A 114
GLY A 116
 None
 1.27A 3v3oB-5jh8A:
undetectable		 3v3oB-5jh8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqvA-5jh8A:
33.3		 3wqvA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqwA-5jh8A:
33.4		 3wqwA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.26A 5iqbA-5jh8A:
undetectable		 5iqbA-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.33A 5iqbD-5jh8A:
undetectable		 5iqbD-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 TYR A 219
GLY A 218
THR A 271
GLY A  63
 6KY  A 504 (-3.7A)
None
None
None
 0.72A 5jlcA-5jh8A:
undetectable		 5jlcA-5jh8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 TRP A 270
HIS A 267
ALA A 179
GLY A 190
THR A 252
 None
MLY  A 222 ( 2.7A)
None
None
None
 1.37A 5vyhA-5jh8A:
undetectable		 5vyhA-5jh8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 145
PRO A 144
ASP A 197
ASP A 192
ASP A 177
 None
None
None
None
6KY  A 504 (-2.6A)
 1.24A 5wwsB-5jh8A:
undetectable		 5wwsB-5jh8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		3 / 3 TYR A 287
ASN A 212
LEU A 198
 None
 0.77A 6b58A-5jh8A:
undetectable		 6b58A-5jh8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ARG A 275
THR A 235
GLN A 236
ASP A 220
 None
 1.21A 6ectA-5jh8A:
undetectable		 6ectA-5jh8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 5 ARG A 275
THR A 235
GLN A 236
ASP A 220
 None
 1.25A 6ecxA-5jh8A:
undetectable		 6ecxA-5jh8A:
21.97