SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 142
GLY A  61
HIS A  63
ILE A 191
 None
 0.89A 1gtnF-5jheA:
undetectable
1gtnG-5jheA:
undetectable		 1gtnF-5jheA:
11.20
1gtnG-5jheA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 142
GLY A  61
HIS A  63
ILE A 191
 None
 0.85A 1gtnJ-5jheA:
undetectable
1gtnK-5jheA:
undetectable		 1gtnJ-5jheA:
11.20
1gtnK-5jheA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 243
GLY A 214
ILE A 242
ALA A 239
GLU A 238
 None
 1.34A 1mrgA-5jheA:
undetectable		 1mrgA-5jheA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 117
PHE A 161
ASN A 114
 None
 0.86A 1sg9B-5jheA:
undetectable		 1sg9B-5jheA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 144
PHE A  37
VAL A 196
MET A 201
 None
 1.09A 1wrlA-5jheA:
undetectable
1wrlB-5jheA:
undetectable		 1wrlA-5jheA:
14.15
1wrlB-5jheA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 221
ALA A 208
ARG A 264
PRO A 222
 None
 1.39A 2ql8A-5jheA:
undetectable
2ql8B-5jheA:
undetectable		 2ql8A-5jheA:
14.86
2ql8B-5jheA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 350
LEU A 346
ILE A 370
ARG A 369
 None
 0.97A 2rlfA-5jheA:
undetectable
2rlfB-5jheA:
undetectable		 2rlfA-5jheA:
8.67
2rlfB-5jheA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  40
ILE A 191
ALA A  73
GLY A 162
LEU A 129
 None
 1.20A 2v0mB-5jheA:
undetectable		 2v0mB-5jheA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  62
GLY A  74
VAL A  89
ALA A 132
PHE A 145
 None
 1.21A 3dh0A-5jheA:
undetectable		 3dh0A-5jheA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 283
ASP A 231
ASP A 280
 None
 0.85A 3jb3A-5jheA:
undetectable		 3jb3A-5jheA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  59
ILE A  21
CYH A  23
PHE A 161
GLY A  74
 None
 1.43A 3ko0A-5jheA:
undetectable
3ko0C-5jheA:
undetectable		 3ko0A-5jheA:
14.83
3ko0C-5jheA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  74
GLY A  59
ILE A  21
CYH A  23
PHE A 161
 None
 1.41A 3ko0F-5jheA:
undetectable
3ko0G-5jheA:
undetectable		 3ko0F-5jheA:
14.83
3ko0G-5jheA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  74
GLY A  59
ILE A  21
CYH A  23
PHE A 161
 None
 1.37A 3ko0H-5jheA:
undetectable
3ko0I-5jheA:
undetectable		 3ko0H-5jheA:
14.83
3ko0I-5jheA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 227
ASP A 225
ALA A 239
TYR A 269
 None
 1.00A 4k0bB-5jheA:
undetectable		 4k0bB-5jheA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 227
ASP A 225
ALA A 239
TYR A 269
 None
 1.02A 4l7iB-5jheA:
undetectable		 4l7iB-5jheA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 247
GLU A 245
LEU A 298
SER A 266
ALA A 240
 None
 1.26A 4wnuD-5jheA:
undetectable		 4wnuD-5jheA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 280
LEU A 237
GLY A 234
 None
 0.50A 4xmfA-5jheA:
undetectable		 4xmfA-5jheA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  71
PHE A  62
VAL A 171
ILE A  21
 None
 0.99A 4zzbC-5jheA:
4.7
4zzbD-5jheA:
4.8		 4zzbC-5jheA:
21.09
4zzbD-5jheA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   9
GLY A  59
ASP A  14
SER A 187
VAL A 170
 None
 1.24A 5d0yA-5jheA:
2.4		 5d0yA-5jheA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  57
THR A  33
CYH A  23
LEU A 129
 None
 1.46A 5kxiD-5jheA:
6.6
5kxiE-5jheA:
5.3		 5kxiD-5jheA:
18.72
5kxiE-5jheA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 165
ALA A  73
PHE A  37
PHE A 144
LEU A  25
 None
 1.26A 5tudD-5jheA:
4.4		 5tudD-5jheA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7
(Saccharomyces
cerevisiae) 		5 / 9 ASN A 176
ILE A 146
GLU A 125
VAL A 164
ILE A  21
 None
 1.42A 6hloA-5jheA:
2.7		 6hloA-5jheA:
20.04