SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 GLY A 253
ASP A  68
GLY A 304
ILE A 303
ALA A 264
 None
 0.99A 1sguB-5jhoA:
undetectable		 1sguB-5jhoA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 GLY A 253
ASP A  68
GLY A 304
ILE A 303
ALA A 264
 None
 1.03A 2b7zA-5jhoA:
undetectable		 2b7zA-5jhoA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 GLY A 253
ASP A  68
GLY A 304
ILE A 303
ALA A 264
 None
 0.97A 2b7zB-5jhoA:
undetectable		 2b7zB-5jhoA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		3 / 3 VAL A  59
GLU A  56
GLU A  57
 None
 0.77A 2nv4A-5jhoA:
undetectable		 2nv4A-5jhoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 GLY A  51
ILE A 310
ASP A 313
LEU A 329
LEU A 120
 None
 0.90A 2nxeB-5jhoA:
undetectable		 2nxeB-5jhoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 GLY A  51
ILE A 310
ASP A 313
LEU A 329
LEU A 120
 None
 0.90A 2zbpA-5jhoA:
undetectable		 2zbpA-5jhoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 THR A  83
LEU A 113
SER A 112
SER A 248
ILE A 333
 None
 1.25A 3frqA-5jhoA:
undetectable		 3frqA-5jhoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 11 ALA A 264
ASN A 249
LEU A 287
ILE A 134
THR A 124
 None
 1.24A 3jw5A-5jhoA:
undetectable		 3jw5A-5jhoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 LEU A 108
GLY A 304
ALA A 308
PHE A 288
LEU A 120
 None
 1.10A 4hytA-5jhoA:
undetectable		 4hytA-5jhoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		5 / 12 LEU A 108
GLY A 304
ALA A 308
PHE A 288
LEU A 120
 None
 1.08A 4hytC-5jhoA:
undetectable		 4hytC-5jhoA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		4 / 4 GLY A 304
LEU A  67
VAL A 252
GLU A  69
 None
 1.23A 5yw0A-5jhoA:
undetectable		 5yw0A-5jhoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		4 / 6 ASP A 328
GLN A  47
VAL A 319
GLU A 325
 None
 1.06A 6djzB-5jhoA:
undetectable		 6djzB-5jhoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens) 		4 / 8 ASP A  92
ARG A 305
GLU A  66
VAL A 280
 None
 1.17A 6fbvD-5jhoA:
undetectable		 6fbvD-5jhoA:
15.24