SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 9 LEU A 493
THR A 541
VAL A 540
LEU A 543
ALA A 549
 None
 1.39A 1fo4A-5jhqA:
undetectable		 1fo4A-5jhqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5jhq TANKYRASE-1
(Homo
sapiens) 		4 / 7 GLU A 567
VAL A 573
MET A 574
LEU A 526
 None
 0.67A 1hk3A-5jhqA:
undetectable		 1hk3A-5jhqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5jhq TANKYRASE-1
(Homo
sapiens) 		4 / 8 SER A 266
ALA A 256
ALA A 289
LEU A 286
 None
 0.90A 2bxmA-5jhqA:
undetectable		 2bxmA-5jhqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 12 LEU A 453
GLY A 458
ALA A 459
ASP A 460
LEU A 454
 None
 0.92A 3ogqB-5jhqA:
undetectable		 3ogqB-5jhqA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 269
ILE A 251
HIS A 221
LEU A 220
 None
 1.24A 3olsB-5jhqA:
undetectable		 3olsB-5jhqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 9 LEU A 493
THR A 541
VAL A 540
LEU A 543
ALA A 549
 None
 1.44A 3unaB-5jhqA:
undetectable		 3unaB-5jhqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 9 LEU A 493
THR A 541
VAL A 540
LEU A 543
ALA A 549
 None
 1.40A 3uncB-5jhqA:
undetectable		 3uncB-5jhqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5jhq TANKYRASE-1
(Homo
sapiens) 		4 / 8 LEU A 406
VAL A 450
LEU A 453
ALA A 459
 None
 0.76A 3uniB-5jhqA:
undetectable		 3uniB-5jhqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5jhq TANKYRASE-1
(Homo
sapiens) 		4 / 5 HIS A 414
GLY A 413
TYR A 379
TYR A 412
 None
 1.10A 4ae1B-5jhqA:
undetectable		 4ae1B-5jhqA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 12 MET A 584
ALA A 565
LEU A 526
LEU A 545
HIS A 578
 None
 1.12A 4j24D-5jhqA:
undetectable		 4j24D-5jhqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 12 LEU A 267
LEU A 269
ILE A 251
HIS A 221
LEU A 220
 None
 1.18A 4j26B-5jhqA:
undetectable		 4j26B-5jhqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 9 LEU A 453
GLY A 458
ALA A 459
ASP A 460
THR A 418
 None
 1.18A 4njtD-5jhqA:
undetectable		 4njtD-5jhqA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 11 LEU A 480
ARG A 481
LEU A 484
GLU A 441
LEU A 439
 None
 1.09A 4wg0B-5jhqA:
undetectable
4wg0C-5jhqA:
undetectable
4wg0D-5jhqA:
undetectable		 4wg0B-5jhqA:
3.32
4wg0C-5jhqA:
3.32
4wg0D-5jhqA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 11 LEU A 480
ARG A 481
LEU A 484
GLU A 441
LEU A 439
 None
 1.06A 4wg0D-5jhqA:
undetectable
4wg0E-5jhqA:
undetectable
4wg0F-5jhqA:
undetectable		 4wg0D-5jhqA:
3.32
4wg0E-5jhqA:
3.32
4wg0F-5jhqA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 11 LEU A 480
ARG A 481
LEU A 484
GLU A 441
LEU A 439
 None
 1.17A 4wg0F-5jhqA:
undetectable
4wg0G-5jhqA:
undetectable
4wg0H-5jhqA:
undetectable		 4wg0F-5jhqA:
3.32
4wg0G-5jhqA:
3.32
4wg0H-5jhqA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5jhq TANKYRASE-1
(Homo
sapiens) 		3 / 3 ASP A 279
GLY A 248
ASP A 246
 None
 0.48A 4xdtA-5jhqA:
undetectable		 4xdtA-5jhqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5jhq TANKYRASE-1
(Homo
sapiens) 		3 / 3 ASP A 432
GLY A 401
ASP A 399
 None
 0.59A 4xdtA-5jhqA:
undetectable		 4xdtA-5jhqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5jhq TANKYRASE-1
(Homo
sapiens) 		4 / 6 VAL A 231
HIS A 234
LEU A 235
LEU A 186
 None
 1.09A 5hrqB-5jhqA:
undetectable
5hrqI-5jhqA:
undetectable
5hrqJ-5jhqA:
undetectable		 5hrqB-5jhqA:
4.58
5hrqI-5jhqA:
4.12
5hrqJ-5jhqA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5jhq TANKYRASE-1
(Homo
sapiens) 		5 / 12 LYS A 210
ILE A 251
HIS A 221
ALA A 240
LEU A 236
 None
 1.08A 5zwrA-5jhqA:
undetectable		 5zwrA-5jhqA:
24.45