SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 10 LEU A 262
VAL A 239
TYR A 241
TYR A 232
LEU A 202
 None
 1.43A 1fkoA-5jifA:
undetectable		 1fkoA-5jifA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 12 GLU A 105
GLY A 106
TYR A  92
TRP A 301
ARG A 300
 None
None
None
None
NAG  A 818 (-3.7A)
 1.40A 2zvjA-5jifA:
undetectable		 2zvjA-5jifA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		3 / 3 MET A 141
GLU A 105
ASN A  80
 None
 0.85A 3a27A-5jifA:
undetectable		 3a27A-5jifA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 12 GLU A 105
GLY A 106
TYR A  92
TRP A 301
ARG A 300
 None
None
None
None
NAG  A 818 (-3.7A)
 1.40A 3bwyA-5jifA:
undetectable		 3bwyA-5jifA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 8 PHE A 182
VAL A 163
GLN A 230
GLY A 184
 None
None
NA  A 801 (-3.5A)
None
 0.95A 3hjoA-5jifA:
undetectable		 3hjoA-5jifA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 8 ASP A 308
SER A  81
PHE A 322
LEU A 137
 None
None
NAG  A 818 ( 4.8A)
None
 1.05A 3m0wE-5jifA:
undetectable
3m0wF-5jifA:
undetectable
3m0wG-5jifA:
undetectable
3m0wH-5jifA:
undetectable		 3m0wE-5jifA:
14.25
3m0wF-5jifA:
14.25
3m0wG-5jifA:
14.25
3m0wH-5jifA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 10 LEU A 147
SER A  85
PHE A  86
ILE A 283
PHE A  91
 None
None
None
None
NAG  A 803 ( 4.8A)
 1.28A 3m0wE-5jifA:
undetectable
3m0wF-5jifA:
undetectable
3m0wG-5jifA:
undetectable
3m0wH-5jifA:
undetectable		 3m0wE-5jifA:
14.25
3m0wF-5jifA:
14.25
3m0wG-5jifA:
14.25
3m0wH-5jifA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 PRO A 180
ILE A 152
TYR A 232
PHE A 200
 None
 1.24A 4g10A-5jifA:
undetectable		 4g10A-5jifA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 8 LEU A  40
ARG A  45
VAL A 107
GLY A 106
 None
 0.93A 4klrB-5jifA:
undetectable		 4klrB-5jifA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 9 THR A 277
ILE A 152
LEU A 260
ILE A 258
PHE A 200
 NA  A 801 ( 4.1A)
None
None
None
None
 1.27A 4r38C-5jifA:
undetectable		 4r38C-5jifA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 12 GLY A  42
SER A 299
ASP A  43
ALA A  76
TYR A  92
 None
 1.25A 4ymgB-5jifA:
undetectable		 4ymgB-5jifA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WP1_A_BEZA403_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 4 GLY A 114
PHE A 115
ASN A 123
LYS A 116
 None
 1.29A 5wp1A-5jifA:
0.0		 5wp1A-5jifA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		4 / 6 GLY A 158
GLY A 161
PRO A 162
GLY A 184
 None
 0.62A 6ag0C-5jifA:
undetectable		 6ag0C-5jifA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 12 VAL A 113
ASP A  90
ASN A  80
GLU A 105
GLY A 106
 None
 1.34A 6gnfA-5jifA:
undetectable		 6gnfA-5jifA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5jif HEMAGGLUTININ-ESTERA
SE
(Murine
coronavirus) 		5 / 12 VAL A 113
ASP A  90
ASN A  80
GLU A 105
GLY A 106
 None
 1.34A 6gnfC-5jifA:
undetectable		 6gnfC-5jifA:
21.79