SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.35A 1os2A-5jigA:
3.2		 1os2A-5jigA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.30A 1os2D-5jigA:
2.1		 1os2D-5jigA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 10 THR A  62
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.68A 1r55A-5jigA:
4.0		 1r55A-5jigA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1uttA-5jigA:
3.6		 1uttA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1utzA-5jigA:
3.1		 1utzA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 1utzB-5jigA:
2.3		 1utzB-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.31A 1y93A-5jigA:
3.2		 1y93A-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		5 / 12 MET A  37
LEU A  99
LEU A  24
LEU A  95
VAL A  91
 None
 1.14A 2c12C-5jigA:
undetectable		 2c12C-5jigA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.31A 2hu6A-5jigA:
3.4		 2hu6A-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.44A 2jihA-5jigA:
3.9		 2jihA-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 8 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.51A 2jihB-5jigA:
4.3		 2jihB-5jigA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A  24
VAL A 103
LEU A 114
ARG A  41
 None
 1.09A 2oiqA-5jigA:
undetectable		 2oiqA-5jigA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A  14
HIS A  16
PRO A  15
TYR A  82
 None
 1.16A 2ombC-5jigA:
undetectable
2ombD-5jigA:
undetectable		 2ombC-5jigA:
20.00
2ombD-5jigA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.44A 2ow9A-5jigA:
3.4		 2ow9A-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.42A 2ow9B-5jigA:
4.2		 2ow9B-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.47A 2ozrC-5jigA:
3.1		 2ozrC-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.45A 2ozrD-5jigA:
3.2		 2ozrD-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.47A 2ozrE-5jigA:
3.0		 2ozrE-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A  97
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.36A 2ozrF-5jigA:
4.1		 2ozrF-5jigA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 3hy7A-5jigA:
3.8		 3hy7A-5jigA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		6 / 9 LEU A  63
THR A  94
HIS A  97
GLU A  98
HIS A 101
HIS A 107
 None
None
NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.38A 3hy7B-5jigA:
4.1		 3hy7B-5jigA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.42A 3kecA-5jigA:
3.3		 3kecA-5jigA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 3likA-5jigA:
2.4		 3likA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.36A 3lilA-5jigA:
3.3		 3lilA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.30A 3ljgA-5jigA:
3.3		 3ljgA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.32A 3lkaA-5jigA:
3.4		 3lkaA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 6 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.53A 4a7bA-5jigA:
4.0		 4a7bA-5jigA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.33A 5n5jA-5jigA:
3.3		 5n5jA-5jigA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.34A 5n5kA-5jigA:
2.4		 5n5kA-5jigA:
21.95