SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 GLU A 302
LEU A 303
VAL A 436
MET A 435
 None
 1.08A 1hk1A-5jijA:
undetectable		 1hk1A-5jijA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_B_HSMB601_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 PHE A 177
GLN A 148
TYR A 119
TRP A 116
LEU A 190
 None
 1.37A 1jqdB-5jijA:
1.6		 1jqdB-5jijA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 395
LEU A 368
ARG A 365
GLN A 318
LEU A 282
 None
EDO  A 507 (-4.7A)
None
None
None
 1.33A 1nhzA-5jijA:
undetectable		 1nhzA-5jijA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.99A 2q6hA-5jijA:
undetectable		 2q6hA-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.99A 2q72A-5jijA:
undetectable		 2q72A-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.98A 2qb4A-5jijA:
undetectable		 2qb4A-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.99A 2qeiA-5jijA:
undetectable		 2qeiA-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 LEU A 297
ARG A 296
VAL A 295
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 1.22A 2qeiA-5jijA:
undetectable		 2qeiA-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLY A  53
ILE A 163
SER A  10
THR A 130
 None
 0.92A 2yoeB-5jijA:
undetectable
2yoeC-5jijA:
undetectable		 2yoeB-5jijA:
21.08
2yoeC-5jijA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 243
LEU A 200
ALA A 472
PHE A 166
LEU A 195
 None
 1.19A 3vywB-5jijA:
2.4		 3vywB-5jijA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 243
LEU A 200
GLY A 202
PHE A 166
LEU A 195
 None
 0.99A 3vywC-5jijA:
undetectable		 3vywC-5jijA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 243
LEU A 200
ALA A 472
PHE A 166
LEU A 195
 None
 1.16A 3vywD-5jijA:
2.7		 3vywD-5jijA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 LEU A  98
PHE A  93
TRP A 115
PRO A 109
 None
 1.19A 4j7uD-5jijA:
4.0		 4j7uD-5jijA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.71A 4k8cA-5jijA:
5.5		 4k8cA-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.69A 4kahA-5jijA:
5.0		 4kahA-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.69A 4kahB-5jijA:
4.6		 4kahB-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.72A 4kanA-5jijA:
5.2		 4kanA-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.70A 4kanB-5jijA:
4.5		 4kanB-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.69A 4kbeA-5jijA:
5.0		 4kbeA-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.70A 4kbeB-5jijA:
5.1		 4kbeB-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 GLU A 393
VAL A 390
LEU A 368
VAL A 363
 None
None
EDO  A 507 (-4.7A)
EDO  A 510 ( 4.2A)
 0.99A 4lb0B-5jijA:
undetectable		 4lb0B-5jijA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.69A 4lbgA-5jijA:
4.5		 4lbgA-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 SER A  94
TYR A 119
PRO A 100
 None
 0.69A 4lbgB-5jijA:
4.5		 4lbgB-5jijA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 122
VAL A  15
LEU A 147
ALA A 129
LEU A 154
 None
 0.93A 4m11B-5jijA:
undetectable		 4m11B-5jijA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 303
LEU A 304
ALA A 301
LEU A 281
LEU A 428
 None
None
EDO  A 505 ( 3.7A)
None
EDO  A 504 (-4.5A)
 1.08A 4pxmA-5jijA:
undetectable		 4pxmA-5jijA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A  47
GLY A 164
PRO A 151
LEU A 154
ARG A  51
 None
 1.27A 4x61A-5jijA:
3.7		 4x61A-5jijA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 MET A 450
GLN A 419
ARG A 449
 None
None
EDO  A 508 (-3.1A)
 1.08A 5ewzB-5jijA:
2.1		 5ewzB-5jijA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 203
PHE A 207
LEU A 214
GLY A 231
VAL A 242
 None
 1.22A 5i71A-5jijA:
undetectable		 5i71A-5jijA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 203
PHE A 207
LEU A 214
GLY A 231
VAL A 242
 None
 1.21A 5i75A-5jijA:
undetectable		 5i75A-5jijA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A  58
SER A  82
ARG A 118
GLU A 121
VAL A 122
 None
 1.34A 5o4yD-5jijA:
undetectable
5o4yE-5jijA:
undetectable		 5o4yD-5jijA:
2.25
5o4yE-5jijA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 12 LEU A 303
LEU A 304
ALA A 301
LEU A 281
LEU A 379
LEU A 428
 None
None
EDO  A 505 ( 3.7A)
None
None
EDO  A 504 (-4.5A)
 1.39A 5toaA-5jijA:
undetectable		 5toaA-5jijA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 PHE A 126
LEU A  74
LEU A  19
VAL A  13
 None
 1.36A 5xxiA-5jijA:
undetectable		 5xxiA-5jijA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 ARG A 324
ARG A 286
THR A 321
PRO A 322
 None
None
EDO  A 507 (-2.9A)
EDO  A 509 (-4.3A)
 1.49A 6a4iB-5jijA:
undetectable		 6a4iB-5jijA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 ALA A 391
VAL A 406
ALA A 420
VAL A 423
GLY A 418
 None
 1.26A 6bklA-5jijA:
undetectable
6bklB-5jijA:
undetectable
6bklC-5jijA:
undetectable
6bklD-5jijA:
undetectable		 6bklA-5jijA:
4.42
6bklB-5jijA:
4.42
6bklC-5jijA:
4.42
6bklD-5jijA:
4.42