SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 12 PRO A 117
HIS A  74
GLY A  44
SER A 121
GLY A  48
 None
 1.14A 1ffyA-5jipA:
undetectable		 1ffyA-5jipA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 GLY A 261
TRP A 251
VAL A 235
ALA A 302
 None
 0.96A 1p6kA-5jipA:
undetectable		 1p6kA-5jipA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 12 PRO A 117
HIS A  74
GLY A  44
SER A 121
GLY A  48
 None
 1.14A 1qu2A-5jipA:
undetectable		 1qu2A-5jipA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 ASP A 113
TYR A 149
ASN A 220
GLU A  21
 MES  A 401 (-2.8A)
MES  A 401 ( 2.6A)
None
None
 1.10A 1rjdA-5jipA:
undetectable		 1rjdA-5jipA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 ASP A 113
TYR A 149
ASN A 220
GLU A  21
 MES  A 401 (-2.8A)
MES  A 401 ( 2.6A)
None
None
 1.11A 1rjdB-5jipA:
undetectable		 1rjdB-5jipA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 ASP A 113
TYR A 149
ASN A 220
GLU A  21
 MES  A 401 (-2.8A)
MES  A 401 ( 2.6A)
None
None
 1.10A 1rjdC-5jipA:
undetectable		 1rjdC-5jipA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 GLU A 115
TYR A 149
ASP A 206
ARG A 182
 MES  A 401 ( 2.7A)
MES  A 401 ( 2.6A)
None
None
 1.02A 2a3bB-5jipA:
9.8		 2a3bB-5jipA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 12 ILE A  68
THR A  14
PRO A  17
LEU A 108
ILE A 226
 None
 0.98A 2cd2A-5jipA:
undetectable		 2cd2A-5jipA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 ARG A 144
GLU A 301
ASN A 254
ALA A 234
 None
 1.25A 2ejfB-5jipA:
undetectable		 2ejfB-5jipA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 7 ARG A 144
GLU A 301
ASN A 254
ALA A 234
 None
 1.25A 2ejgA-5jipA:
undetectable		 2ejgA-5jipA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 11 LEU A 112
HIS A  74
SER A  79
LEU A 148
MET A 173
 None
 1.16A 2idkA-5jipA:
undetectable
2idkB-5jipA:
undetectable
2idkC-5jipA:
undetectable
2idkD-5jipA:
undetectable		 2idkA-5jipA:
18.87
2idkB-5jipA:
18.87
2idkC-5jipA:
18.87
2idkD-5jipA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 10 LEU A 148
MET A 173
LEU A 112
HIS A  74
THR A 116
 None
 1.28A 2idkA-5jipA:
undetectable
2idkB-5jipA:
undetectable
2idkC-5jipA:
undetectable
2idkD-5jipA:
undetectable		 2idkA-5jipA:
18.87
2idkB-5jipA:
18.87
2idkC-5jipA:
18.87
2idkD-5jipA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 10 LEU A 148
MET A 173
SER A  79
LEU A 112
HIS A  74
 None
 1.08A 2idkA-5jipA:
undetectable
2idkB-5jipA:
undetectable
2idkC-5jipA:
undetectable
2idkD-5jipA:
undetectable		 2idkA-5jipA:
18.87
2idkB-5jipA:
18.87
2idkC-5jipA:
18.87
2idkD-5jipA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 12 TYR A 158
ILE A 131
VAL A 114
PHE A 154
ASP A 119
 None
 1.35A 2qeoA-5jipA:
undetectable		 2qeoA-5jipA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		5 / 12 SER A  35
ASN A  34
GLY A 208
ASP A 206
THR A 205
 None
 1.42A 3a25A-5jipA:
undetectable		 3a25A-5jipA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1226_0
(THAUMATIN-LIKE
PROTEIN)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 5 GLU A 115
TYR A  73
ASP A 113
ASN A  20
 MES  A 401 ( 2.7A)
MES  A 401 (-3.2A)
MES  A 401 (-2.8A)
MES  A 401 (-3.8A)
 1.11A 3zs3A-5jipA:
0.0		 3zs3A-5jipA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 5 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.85A 4w5oA-5jipA:
2.4		 4w5oA-5jipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 5 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.84A 4z4cA-5jipA:
2.2		 4z4cA-5jipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 5 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.85A 4z4dA-5jipA:
undetectable		 4z4dA-5jipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 5 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.85A 4z4eA-5jipA:
2.3		 4z4eA-5jipA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		4 / 6 PRO A 110
VAL A 111
ALA A  72
PHE A  92
 None
 0.86A 5t7bA-5jipA:
2.3		 5t7bA-5jipA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jip CORTICAL-LYTIC
ENZYME
(Clostridium
perfringens) 		3 / 3 ARG A 144
PHE A 303
PHE A 109
 None
 1.05A 6nknC-5jipA:
undetectable
6nknJ-5jipA:
undetectable		 6nknC-5jipA:
19.77
6nknJ-5jipA:
11.79