SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		5 / 12 LEU B 273
LEU B 308
ILE B 290
ALA B 295
LEU B 299
 None
 1.00A 1cqeA-5jirB:
2.2		 1cqeA-5jirB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		5 / 12 LEU B 273
LEU B 308
ILE B 290
ALA B 295
LEU B 299
 None
 1.01A 1cqeB-5jirB:
undetectable		 1cqeB-5jirB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		5 / 11 LEU B 330
LEU B 173
LEU B 112
VAL B 326
ILE B  78
 None
 1.20A 1ee2A-5jirB:
undetectable		 1ee2A-5jirB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		5 / 12 LEU B 273
LEU B 308
ILE B 290
ALA B 295
LEU B 299
 None
 1.02A 2aylB-5jirB:
undetectable		 2aylB-5jirB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.76A 3abkA-5jirB:
undetectable		 3abkA-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.73A 3abkN-5jirB:
undetectable		 3abkN-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.75A 3ag1N-5jirB:
undetectable		 3ag1N-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.73A 3ag2A-5jirB:
undetectable		 3ag2A-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.76A 3ag3A-5jirB:
undetectable		 3ag3A-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.76A 3ag3N-5jirB:
undetectable		 3ag3N-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.67A 3ag4A-5jirB:
undetectable		 3ag4A-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.71A 3ag4N-5jirB:
undetectable		 3ag4N-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.75A 3dtuC-5jirB:
undetectable		 3dtuC-5jirB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		4 / 5 SER B 195
ASP B 294
ASP B 204
ILE B 203
 None
 1.31A 3uj7B-5jirB:
undetectable		 3uj7B-5jirB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 ARG B 436
GLU B 383
ARG B 435
 None
 0.93A 4mwvA-5jirB:
undetectable		 4mwvA-5jirB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		4 / 4 HIS B 180
ALA B 183
VAL B 242
GLU B 310
 None
 1.45A 4n6pA-5jirB:
undetectable		 4n6pA-5jirB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		5 / 12 PHE B 372
ILE B 471
ARG B 436
THR B 445
VAL B 469
 None
 1.07A 4nkvD-5jirB:
undetectable		 4nkvD-5jirB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 ARG B 468
GLU B 214
TYR B 368
 None
 0.87A 4r29D-5jirB:
undetectable		 4r29D-5jirB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 ASP B 129
ARG B 126
TYR B 336
 GOL  B 501 ( 4.1A)
None
None
 0.90A 5a7mA-5jirB:
undetectable		 5a7mA-5jirB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 ASP B 129
ARG B 126
TYR B 336
 GOL  B 501 ( 4.1A)
None
None
 0.88A 5a7mB-5jirB:
undetectable		 5a7mB-5jirB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		4 / 8 ILE B 289
MET B 241
ILE B 298
LEU B 209
 None
 0.97A 5ieoA-5jirB:
undetectable		 5ieoA-5jirB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.72A 5waua-5jirB:
undetectable		 5waua-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.73A 5x19A-5jirB:
undetectable		 5x19A-5jirB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		4 / 7 THR B 444
LEU B 404
ILE B 471
THR B 472
 None
 0.94A 5zsfA-5jirB:
undetectable
5zsfB-5jirB:
undetectable		 5zsfA-5jirB:
13.62
5zsfB-5jirB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.55A 6giqa-5jirB:
undetectable		 6giqa-5jirB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jir OOP FAMILY OMPA-OMPF
PORIN
(Treponema
pallidum) 		3 / 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.73A 6nmfN-5jirB:
undetectable		 6nmfN-5jirB:
22.82