SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOF_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 5	GLY A 191 PRO A 152 ALA A 155 ILE A 159	GLY A 191 ( 0.0A) PRO A 152 ( 1.1A) ALA A 155 ( 0.0A) ILE A 159 ( 0.7A)	0.88A	2aofA-5jjaA: undetectable	2aofA-5jjaA: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LH6_A_NIOA155_1 (LEGHEMOGLOBIN A (NICOTINATE MET))	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 5	PHE A 144 PHE A 150 PHE A 193 VAL A 96	PHE A 144 ( 1.3A) PHE A 150 ( 1.3A) PHE A 193 ( 1.3A) VAL A 96 ( 0.6A)	1.16A	2lh6A-5jjaA: undetectable	2lh6A-5jjaA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1499_1 (CYTOCHROME P450 3A4)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 7	PHE A 163 PHE A 140 SER A 147 PHE A 42	PHE A 163 ( 1.3A) PHE A 140 ( 1.3A) SER A 147 ( 0.0A) PHE A 42 ( 1.3A)	0.93A	2v0mC-5jjaA: undetectable	2v0mC-5jjaA: 22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZ0_B_CLYB900_1 (LINCOSAMIDE NUCLEOTIDYLTRANSFERA SE)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 8	TYR A 263 TYR A 292 PHE A 211 ILE A 207	TYR A 263 ( 1.3A) TYR A 292 ( 1.3A) PHE A 211 ( 1.3A) ILE A 207 ( 0.7A)	1.06A	3jz0B-5jjaA: 2.1	3jz0B-5jjaA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDI_A_SAMA601_0 (METHYLTRANSFERASE)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 12	PHE A 246 GLU A 226 ILE A 227 ALA A 222 ILE A 204	PHE A 246 ( 1.3A) GLU A 226 ( 0.5A) ILE A 227 ( 0.6A) ALA A 222 ( 0.0A) ILE A 204 ( 0.7A)	1.26A	3ndiA-5jjaA: undetectable	3ndiA-5jjaA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_B_SAMB301_1 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	3 / 3	ASP A 278 GLU A 241 SER A 318	ASP A 278 ( 0.6A) GLU A 241 ( 0.6A) SER A 318 ( 0.0A)	0.64A	5bw4B-5jjaA: undetectable	5bw4B-5jjaA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXC_A_ZITA306_1 (PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 7	THR A 282 PHE A 274 ASP A 278 LEU A 239	THR A 282 ( 0.8A) PHE A 274 ( 1.3A) ASP A 278 ( 0.6A) LEU A 239 ( 0.6A)	1.25A	5uxcA-5jjaA: undetectable	5uxcA-5jjaA: 20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZJI_B_PQNB842_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5jja	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 10	ILE A 311 ILE A 369 ALA A 332 LEU A 331 ALA A 346	ILE A 311 ( 0.6A) ILE A 369 ( 0.7A) ALA A 332 ( 0.0A) LEU A 331 ( 0.6A) ALA A 346 ( 0.0A)	1.42A	5zjiB-5jjaA: undetectable	5zjiB-5jjaA: 13.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AOF_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",4,"GLY A 191;PRO A 152;ALA A 155;ILE A 159","GLY A 191 ( 0.0A);PRO A 152 ( 1.1A);ALA A 155 ( 0.0A);ILE A 159 ( 0.7A)","0.88A","2aofA-5jjaA:undetectable","2aofA-5jjaA:16.72"],["2LH6_A_NIOA155_1","LEGHEMOGLOBIN A (NICOTINATE MET)","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",4,"PHE A 144;PHE A 150;PHE A 193;VAL A  96","PHE A 144 ( 1.3A);PHE A 150 ( 1.3A);PHE A 193 ( 1.3A);VAL A  96 ( 0.6A)","1.16A","2lh6A-5jjaA:undetectable","2lh6A-5jjaA:20.00"],["2V0M_C_KLNC1499_1","CYTOCHROME P450 3A4","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",4,"PHE A 163;PHE A 140;SER A 147;PHE A  42","PHE A 163 ( 1.3A);PHE A 140 ( 1.3A);SER A 147 ( 0.0A);PHE A  42 ( 1.3A)","0.93A","2v0mC-5jjaA:undetectable","2v0mC-5jjaA:22.02"],["3JZ0_B_CLYB900_1","LINCOSAMIDE NUCLEOTIDYLTRANSFERASE","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",4,"TYR A 263;TYR A 292;PHE A 211;ILE A 207","TYR A 263 ( 1.3A);TYR A 292 ( 1.3A);PHE A 211 ( 1.3A);ILE A 207 ( 0.7A)","1.06A","3jz0B-5jjaA:2.1","3jz0B-5jjaA:22.37"],["3NDI_A_SAMA601_0","METHYLTRANSFERASE","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"PHE A 246;GLU A 226;ILE A 227;ALA A 222;ILE A 204","PHE A 246 ( 1.3A);GLU A 226 ( 0.5A);ILE A 227 ( 0.6A);ALA A 222 ( 0.0A);ILE A 204 ( 0.7A)","1.26A","3ndiA-5jjaA:undetectable","3ndiA-5jjaA:21.56"],["5BW4_B_SAMB301_1","16S RRNA (ADENINE(1408)-N(1))-METHYLTRANSFERASE","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",3,"ASP A 278;GLU A 241;SER A 318","ASP A 278 ( 0.6A);GLU A 241 ( 0.6A);SER A 318 ( 0.0A)","0.64A","5bw4B-5jjaA:undetectable","5bw4B-5jjaA:20.28"],["5UXC_A_ZITA306_1","PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",4,"THR A 282;PHE A 274;ASP A 278;LEU A 239","THR A 282 ( 0.8A);PHE A 274 ( 1.3A);ASP A 278 ( 0.6A);LEU A 239 ( 0.6A)","1.25A","5uxcA-5jjaA:undetectable","5uxcA-5jjaA:20.44"],["5ZJI_B_PQNB842_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5jja","SERINE\/THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"ILE A 311;ILE A 369;ALA A 332;LEU A 331;ALA A 346","ILE A 311 ( 0.6A);ILE A 369 ( 0.7A);ALA A 332 ( 0.0A);LEU A 331 ( 0.6A);ALA A 346 ( 0.0A)","1.42A","5zjiB-5jjaA:undetectable","5zjiB-5jjaA:13.21"]]