SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 9 GLY A  76
THR A  88
THR A  78
THR A  69
ALA A 147
 LLP  A  42 ( 4.6A)
None
None
None
None
 1.36A 1gtnQ-5jjcA:
undetectable
1gtnR-5jjcA:
undetectable		 1gtnQ-5jjcA:
12.87
1gtnR-5jjcA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 8 GLY A 185
GLY A 237
LEU A 214
GLY A 235
 LLP  A  42 ( 3.4A)
None
None
None
 0.75A 1jhaA-5jjcA:
undetectable		 1jhaA-5jjcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 177
CYH A  26
THR A  24
ILE A 286
LEU A 292
 None
 1.33A 1m2zD-5jjcA:
undetectable		 1m2zD-5jjcA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLN A 157
THR A 162
ALA A 164
GLY A 186
GLY A 190
 None
None
None
LLP  A  42 ( 3.7A)
None
 1.10A 1rjdB-5jjcA:
undetectable		 1rjdB-5jjcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLN A 157
THR A 162
ALA A 164
GLY A 186
GLY A 190
 None
None
None
LLP  A  42 ( 3.7A)
None
 1.06A 1rjdC-5jjcA:
undetectable		 1rjdC-5jjcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 208
LEU A 214
PHE A 217
VAL A 182
ALA A 181
 None
None
None
LLP  A  42 ( 4.0A)
None
 1.08A 2kceB-5jjcA:
undetectable		 2kceB-5jjcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 7 TYR A 218
VAL A 182
GLY A 235
ALA A 212
 None
LLP  A  42 ( 4.0A)
None
None
 0.93A 2wekB-5jjcA:
2.6		 2wekB-5jjcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 8 SER A 251
LEU A 214
TYR A 218
PHE A 246
LEU A 243
 None
 1.01A 3i45A-5jjcA:
2.4		 3i45A-5jjcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		3 / 3 GLN A 174
THR A 171
LEU A 292
 None
 0.61A 3ondA-5jjcA:
3.6		 3ondA-5jjcA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		3 / 3 GLN A 174
THR A 171
LEU A 292
 None
 0.61A 3ondB-5jjcA:
3.6		 3ondB-5jjcA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 11 THR A 153
ALA A  45
ILE A  49
THR A  12
GLU A  33
 None
LLP  A  42 ( 4.1A)
None
None
None
 1.22A 3qelA-5jjcA:
3.4
3qelB-5jjcA:
undetectable		 3qelA-5jjcA:
23.96
3qelB-5jjcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 11 ALA A 109
TYR A 309
ARG A 308
GLY A  71
VAL A 114
 None
 1.11A 3rukD-5jjcA:
undetectable		 3rukD-5jjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 249
GLY A 190
ALA A 192
PHE A 178
ALA A 180
 None
 0.93A 3sudA-5jjcA:
undetectable		 3sudA-5jjcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 249
GLY A 190
ALA A 192
PHE A 178
ALA A 180
 None
 0.89A 3sudC-5jjcA:
undetectable		 3sudC-5jjcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 249
GLY A 190
ALA A 192
PHE A 178
ALA A 180
 None
 0.96A 3sudD-5jjcA:
undetectable		 3sudD-5jjcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 208
LEU A 214
PHE A 217
VAL A 182
ALA A 181
 None
None
None
LLP  A  42 ( 4.0A)
None
 1.11A 4foxD-5jjcA:
undetectable		 4foxD-5jjcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ALA A 181
GLY A 279
LEU A 266
LEU A 263
ALA A 180
 None
 1.14A 4lg1B-5jjcA:
undetectable		 4lg1B-5jjcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 8 GLY A 276
ILE A 282
GLU A 270
LEU A 272
 None
 0.84A 4mwzB-5jjcA:
undetectable		 4mwzB-5jjcA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ALA A 125
SER A 129
GLY A  71
GLN A 236
GLY A 183
 None
None
None
None
LLP  A  42 ( 3.7A)
 1.16A 4uilH-5jjcA:
undetectable
4uilL-5jjcA:
undetectable		 4uilH-5jjcA:
21.76
4uilL-5jjcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 TYR A 309
GLY A 276
SER A 278
LEU A 274
TYR A 305
 None
 1.28A 5hwkA-5jjcA:
undetectable		 5hwkA-5jjcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 TYR A 309
GLY A 276
SER A 278
LEU A 274
TYR A 305
 None
 1.29A 5hwkB-5jjcA:
undetectable		 5hwkB-5jjcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 TYR A 252
ILE A 298
ILE A  28
VAL A 179
ILE A 282
 None
 1.27A 5mvnD-5jjcA:
undetectable		 5mvnD-5jjcA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 TYR A 252
ILE A 298
ILE A  28
VAL A 179
ILE A 282
 None
 1.26A 5mzrA-5jjcA:
undetectable		 5mzrA-5jjcA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLU A  33
VAL A 301
LEU A 243
ALA A 180
GLY A 233
 None
None
None
None
LLP  A  42 ( 4.0A)
 1.17A 5syeB-5jjcA:
undetectable		 5syeB-5jjcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 233
LEU A 111
GLY A  74
PHE A 150
ILE A  75
 LLP  A  42 ( 4.0A)
None
None
None
None
 1.05A 5vooD-5jjcA:
2.4		 5vooD-5jjcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		3 / 3 THR A  12
GLU A 166
HIS A 159
 None
 0.91A 5xioA-5jjcA:
undetectable		 5xioA-5jjcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
LEU A 206
TYR A 218
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 0.99A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
TYR A 218
ASP A 208
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 1.38A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
LEU A 206
TYR A 218
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 0.96A 5zbdB-5jjcA:
undetectable		 5zbdB-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
TYR A 218
ASP A 208
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 1.37A 5zbdB-5jjcA:
undetectable		 5zbdB-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 6 PHE A 246
LEU A 243
ALA A 189
SER A 184
 None
None
None
LLP  A  42 ( 2.6A)
 0.86A 6f88A-5jjcA:
undetectable		 6f88A-5jjcA:
15.71