SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 8 LEU A 247
HIS A 251
LEU A 282
LEU A 279
 None
 0.79A 1e7cA-5jjpA:
undetectable		 1e7cA-5jjpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 8 SER A 184
ASN A 188
ILE A 189
GLY A  92
 None
 1.00A 1meiA-5jjpA:
undetectable		 1meiA-5jjpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 11 THR A 225
SER A 228
PHE A 217
LEU A 312
VAL A 323
 None
 1.43A 1q23G-5jjpA:
undetectable		 1q23G-5jjpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 PHE A 310
LEU A 200
ILE A 201
SER A 284
 None
 1.10A 1sbrA-5jjpA:
undetectable
1sbrB-5jjpA:
undetectable		 1sbrA-5jjpA:
17.16
1sbrB-5jjpA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 LEU A 300
LEU A 303
ILE A 285
ARG A 307
 None
 0.94A 2rlfB-5jjpA:
undetectable
2rlfC-5jjpA:
undetectable		 2rlfB-5jjpA:
6.22
2rlfC-5jjpA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 8 ARG A 206
SER A 211
TYR A  46
VAL A 207
 None
 1.33A 2y05A-5jjpA:
undetectable
2y05B-5jjpA:
4.8		 2y05A-5jjpA:
21.23
2y05B-5jjpA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 5 VAL A  71
VAL A  72
GLN A 121
PHE A  85
 None
 1.39A 3bjwB-5jjpA:
undetectable		 3bjwB-5jjpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 LEU A 275
GLU A 272
PRO A 273
ARG A 244
 None
 1.27A 3ltwA-5jjpA:
undetectable		 3ltwA-5jjpA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 LEU A  86
PHE A  85
ILE A 222
ALA A 223
 None
 0.76A 3mdrA-5jjpA:
undetectable		 3mdrA-5jjpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 PHE A  89
PHE A  95
ALA A  77
ILE A  32
ALA A  31
 None
 1.19A 3nxuB-5jjpA:
undetectable		 3nxuB-5jjpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 10 ILE A 222
ALA A  79
LEU A 226
LEU A  49
VAL A  44
 None
 1.18A 3o02A-5jjpA:
undetectable
3o02B-5jjpA:
undetectable		 3o02A-5jjpA:
19.89
3o02B-5jjpA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 GLY A 229
ALA A 230
ASP A 205
PRO A 234
ILE A  32
 None
 1.13A 3s56A-5jjpA:
undetectable		 3s56A-5jjpA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 7 ALA A 373
PRO A 372
ARG A 370
ALA A 342
 None
 1.08A 3twpA-5jjpA:
undetectable		 3twpA-5jjpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		3 / 3 SER A 126
GLY A 125
GLN A 121
 None
 0.58A 3v4tH-5jjpA:
undetectable		 3v4tH-5jjpA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 7 ASP A 216
PHE A 217
GLY A 289
THR A 316
 None
 0.84A 3vnsA-5jjpA:
44.5		 3vnsA-5jjpA:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 10 ALA A  53
LEU A  86
PHE A  85
ILE A 222
ALA A 223
 None
 0.97A 4j14A-5jjpA:
undetectable		 4j14A-5jjpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 11 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.09A 4j6cA-5jjpA:
undetectable		 4j6cA-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 10 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.10A 4j6cB-5jjpA:
undetectable		 4j6cB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.04A 4j6dA-5jjpA:
undetectable		 4j6dA-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.05A 4j6dB-5jjpA:
undetectable		 4j6dB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.09A 4jbtA-5jjpA:
undetectable		 4jbtA-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 11 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.08A 4jbtB-5jjpA:
undetectable		 4jbtB-5jjpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 GLY A 365
ASP A 349
ASP A 407
ASP A 352
 None
 1.01A 4uckB-5jjpA:
2.3		 4uckB-5jjpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 GLN A 257
GLY A 221
PHE A 310
THR A 324
HIS A 192
 None
 1.39A 5d0yA-5jjpA:
undetectable		 5d0yA-5jjpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 11 GLY A 421
CYH A 420
ALA A 409
LEU A 417
VAL A 350
 None
 1.34A 5hw4B-5jjpA:
2.4		 5hw4B-5jjpA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 7 ASP A 216
PHE A 217
GLY A 289
GLY A 314
 None
 0.90A 5n9xA-5jjpA:
44.6		 5n9xA-5jjpA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		4 / 6 HIS A 343
MET A 348
LEU A 369
GLN A 400
 None
 1.25A 5xdhA-5jjpA:
undetectable
5xdhC-5jjpA:
undetectable		 5xdhA-5jjpA:
10.02
5xdhC-5jjpA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE
(Streptomyces
sp.
MJ635-86F5) 		5 / 12 VAL A 258
ALA A 208
LEU A 279
LEU A 240
LEU A 264
 None
 1.10A 6f6iA-5jjpA:
1.4
6f6iB-5jjpA:
undetectable		 6f6iA-5jjpA:
10.08
6f6iB-5jjpA:
8.88