SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 9 ILE A 501
LEU A 484
GLU A 446
ALA A 453
VAL A 469
 None
 1.27A 1ctrA-5jjqA:
undetectable		 1ctrA-5jjqA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		3 / 3 GLU A 417
HIS A 342
ASP A 326
 None
 0.87A 1i9gA-5jjqA:
4.3		 1i9gA-5jjqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 ALA A  84
GLY A  92
LEU A 118
ALA A 117
LEU A  73
 None
 1.18A 1jipA-5jjqA:
undetectable		 1jipA-5jjqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 PHE A 324
LEU A 196
GLY A 223
VAL A 320
 None
 0.98A 1t88A-5jjqA:
undetectable		 1t88A-5jjqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 LEU A 226
PRO A 234
VAL A 232
ILE A 222
 None
 0.96A 2aoiB-5jjqA:
undetectable		 2aoiB-5jjqA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 4 SER A 372
GLY A 373
HIS A 342
ASP A 326
 None
 1.08A 2oxtC-5jjqA:
2.6		 2oxtC-5jjqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.08A 2riwA-5jjqA:
undetectable
2riwB-5jjqA:
undetectable		 2riwA-5jjqA:
21.03
2riwB-5jjqA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 GLY A 290
GLY A 315
THR A 317
ARG A 434
 6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
6L1  A 601 (-3.5A)
6L1  A 601 (-3.6A)
 0.38A 2wd9A-5jjqA:
33.0		 2wd9A-5jjqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 GLY A 290
GLY A 315
THR A 317
ARG A 434
 6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
6L1  A 601 (-3.5A)
6L1  A 601 (-3.6A)
 0.38A 2wd9B-5jjqA:
33.7		 2wd9B-5jjqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.11A 2xn6A-5jjqA:
undetectable
2xn6B-5jjqA:
undetectable		 2xn6A-5jjqA:
20.77
2xn6B-5jjqA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 ALA A  84
LEU A  63
LEU A 118
LEU A 120
LEU A  60
 None
 1.06A 2xn7A-5jjqA:
undetectable
2xn7B-5jjqA:
undetectable		 2xn7A-5jjqA:
20.77
2xn7B-5jjqA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 LEU A 144
ALA A  84
ILE A  82
ARG A  52
ALA A  59
 None
 1.26A 3axtA-5jjqA:
undetectable		 3axtA-5jjqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 4 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.42A 3g1uA-5jjqA:
2.8		 3g1uA-5jjqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.44A 3g1uC-5jjqA:
4.0		 3g1uC-5jjqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		3 / 3 ARG A 106
GLU A 439
ASP A 425
 None
 0.85A 3g2oA-5jjqA:
undetectable		 3g2oA-5jjqA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.39A 3glqA-5jjqA:
2.7		 3glqA-5jjqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.41A 3glqB-5jjqA:
undetectable		 3glqB-5jjqA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 SER A 372
CYH A 313
PHE A 314
LEU A 220
 None
None
6L1  A 601 (-4.4A)
None
 0.90A 3m0wE-5jjqA:
undetectable
3m0wF-5jjqA:
undetectable
3m0wG-5jjqA:
undetectable
3m0wH-5jjqA:
undetectable		 3m0wE-5jjqA:
10.69
3m0wF-5jjqA:
10.69
3m0wG-5jjqA:
10.69
3m0wH-5jjqA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.41A 3n58A-5jjqA:
5.7		 3n58A-5jjqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 PHE A 404
GLY A 315
PHE A 314
SER A 319
 None
6L1  A 601 (-4.7A)
6L1  A 601 (-4.4A)
None
 1.08A 3tzfB-5jjqA:
undetectable		 3tzfB-5jjqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 11 THR A  77
PHE A 213
SER A  78
LEU A  49
VAL A  33
 None
 1.45A 3u9fN-5jjqA:
undetectable
3u9fO-5jjqA:
undetectable		 3u9fN-5jjqA:
16.51
3u9fO-5jjqA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 9 THR A  77
PHE A 213
SER A  78
LEU A  49
VAL A  33
 None
 1.42A 3u9fP-5jjqA:
undetectable		 3u9fP-5jjqA:
16.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
GLY A 290
THR A 317
LYS A 429
 6L1  A 601 (-3.5A)
6L1  A 601 (-3.3A)
6L1  A 601 (-3.5A)
6L1  A 601 (-2.7A)
 0.93A 3vnsA-5jjqA:
37.9		 3vnsA-5jjqA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
PHE A 217
GLY A 290
THR A 317
 6L1  A 601 (-3.5A)
6L1  A 601 ( 4.7A)
6L1  A 601 (-3.3A)
6L1  A 601 (-3.5A)
 0.74A 3vnsA-5jjqA:
37.9		 3vnsA-5jjqA:
37.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 PHE A 324
GLY A 223
ILE A 200
VAL A 201
 None
 0.89A 3wrkA-5jjqA:
undetectable		 3wrkA-5jjqA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 ARG A 127
THR A  99
GLU A 101
THR A 102
 None
 1.50A 4eahA-5jjqA:
undetectable
4eahE-5jjqA:
undetectable
4eahG-5jjqA:
undetectable		 4eahA-5jjqA:
22.30
4eahE-5jjqA:
22.30
4eahG-5jjqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 11 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.15A 4j6cA-5jjqA:
undetectable		 4j6cA-5jjqA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.16A 4j6cB-5jjqA:
undetectable		 4j6cB-5jjqA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 PHE A  95
ALA A  81
ALA A  84
ALA A  83
LEU A 226
 None
 1.10A 4j6dA-5jjqA:
undetectable		 4j6dA-5jjqA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 ARG A 126
GLY A 137
THR A 136
ARG A 138
 None
 0.93A 4k87A-5jjqA:
2.9		 4k87A-5jjqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 8 LEU A  85
ARG A  52
PRO A 234
SER A 209
VAL A  44
 None
 1.43A 4klrB-5jjqA:
3.3		 4klrB-5jjqA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 11 PHE A 191
SER A 374
ALA A 343
GLY A 194
LEU A 301
 None
None
CL  A 602 (-4.0A)
None
None
 0.96A 4kt0A-5jjqA:
undetectable
4kt0J-5jjqA:
undetectable		 4kt0A-5jjqA:
23.00
4kt0J-5jjqA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 TYR A 379
GLY A 378
PHE A 324
LEU A 370
THR A 377
 None
 1.30A 4ze1A-5jjqA:
undetectable		 4ze1A-5jjqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		3 / 3 GLU A 417
HIS A 342
ASP A 326
 None
 0.71A 5c0oG-5jjqA:
4.4		 5c0oG-5jjqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 GLY A 227
TYR A 192
GLY A 223
LEU A 226
LEU A  86
 None
 1.36A 5hwkA-5jjqA:
undetectable		 5hwkA-5jjqA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 GLY A 227
TYR A 192
GLY A 223
LEU A 226
LEU A  86
 None
 1.37A 5hwkB-5jjqA:
undetectable		 5hwkB-5jjqA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		3 / 3 PRO A 162
ARG A 186
GLU A  14
 None
 0.97A 5j6hA-5jjqA:
undetectable		 5j6hA-5jjqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 10 VAL A 320
LEU A  86
SER A 374
THR A  22
LEU A 196
 None
 1.17A 5mm4B-5jjqA:
undetectable		 5mm4B-5jjqA:
10.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 7 ASP A 216
PHE A 217
GLY A 290
GLY A 315
 6L1  A 601 (-3.5A)
6L1  A 601 ( 4.7A)
6L1  A 601 (-3.3A)
6L1  A 601 (-4.7A)
 0.90A 5n9xA-5jjqA:
38.3		 5n9xA-5jjqA:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 8 LEU A 107
ALA A 122
VAL A 110
GLN A 214
 None
 0.98A 5nu7A-5jjqA:
undetectable		 5nu7A-5jjqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 LEU A 120
LEU A  73
LEU A  93
ILE A 146
LEU A  65
 None
 0.92A 5toaA-5jjqA:
undetectable		 5toaA-5jjqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 6 HIS A 344
MET A 349
LEU A 370
GLN A 401
 None
 1.29A 5xdhA-5jjqA:
undetectable
5xdhC-5jjqA:
undetectable		 5xdhA-5jjqA:
10.50
5xdhC-5jjqA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 5 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.41A 6aphA-5jjqA:
5.4		 6aphA-5jjqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 6 PHE A 139
ARG A 138
LEU A 144
ALA A  84
 None
 0.98A 6b89B-5jjqA:
undetectable		 6b89B-5jjqA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		5 / 12 GLY A 341
HIS A 342
VAL A 331
VAL A 327
ASP A 326
 None
 1.28A 6bxlB-5jjqA:
3.4		 6bxlB-5jjqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 4 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.43A 6f3nA-5jjqA:
2.8		 6f3nA-5jjqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 4 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.43A 6f3nC-5jjqA:
2.2		 6f3nC-5jjqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE
(Streptomyces
sp.
ML694-90F3) 		4 / 4 GLN A 401
THR A 402
THR A 406
HIS A 367
 None
 1.43A 6f3nD-5jjqA:
2.6		 6f3nD-5jjqA:
22.77