SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 PHE A 483
ALA A  93
MET A  94
PHE A 104
TYR A  91
 None
 1.25A 1brpA-5jjtA:
undetectable		 1brpA-5jjtA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 PHE A 321
SER A 265
ILE A 269
GLU A 304
 None
 0.82A 1eupA-5jjtA:
undetectable		 1eupA-5jjtA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 6 PHE A 301
VAL A 305
LEU A 309
PHE A 321
 None
 0.98A 1wrlB-5jjtA:
undetectable		 1wrlB-5jjtA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 HIS A 328
GLY A 332
LEU A 408
LEU A 406
ILE A 448
 None
 1.18A 1zq9A-5jjtA:
undetectable		 1zq9A-5jjtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 LEU A 272
GLU A 291
GLY A 256
ALA A 286
ALA A 327
 None
 1.25A 2br4B-5jjtA:
undetectable		 2br4B-5jjtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 6 PRO A 375
LEU A 341
ARG A 386
GLY A 389
 None
None
NI  A 503 ( 4.3A)
None
 1.16A 2hs2B-5jjtA:
undetectable		 2hs2B-5jjtA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 5 SER A 433
VAL A 431
VAL A 229
SER A 412
 None
 1.06A 2j9cA-5jjtA:
undetectable
2j9cB-5jjtA:
undetectable
2j9cC-5jjtA:
undetectable		 2j9cA-5jjtA:
13.12
2j9cB-5jjtA:
13.12
2j9cC-5jjtA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 11 SER A 292
ASN A 296
HIS A 230
ILE A 269
SER A 265
 None
None
NI  A 502 (-3.8A)
None
None
 1.48A 2vkeA-5jjtA:
0.7		 2vkeA-5jjtA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 7 HIS A 413
HIS A 290
ARG A 261
TYR A  63
 NI  A 501 (-3.6A)
NI  A 503 (-4.1A)
NI  A 503 (-3.5A)
None
 1.13A 2vmyA-5jjtA:
undetectable
2vmyB-5jjtA:
undetectable		 2vmyA-5jjtA:
21.96
2vmyB-5jjtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 TYR A  63
HIS A 413
HIS A 290
ARG A 261
 None
NI  A 501 (-3.6A)
NI  A 503 (-4.1A)
NI  A 503 (-3.5A)
 1.14A 2vmyA-5jjtA:
undetectable
2vmyB-5jjtA:
undetectable		 2vmyA-5jjtA:
21.96
2vmyB-5jjtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		3 / 3 LEU A 209
VAL A 320
ARG A 357
 None
 0.82A 3b0wB-5jjtA:
undetectable		 3b0wB-5jjtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 ILE A 448
GLY A 419
PHE A 432
LEU A 428
ARG A 411
 None
 1.14A 3em0B-5jjtA:
undetectable		 3em0B-5jjtA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 10 PHE A 462
VAL A 229
TYR A 252
PHE A 254
GLY A 244
 None
 1.35A 3r6wA-5jjtA:
undetectable
3r6wB-5jjtA:
undetectable		 3r6wA-5jjtA:
18.37
3r6wB-5jjtA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 LEU A 285
LEU A 272
VAL A 177
MET A 181
THR A 202
 None
 1.29A 3zqtA-5jjtA:
undetectable		 3zqtA-5jjtA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 4 LEU A 209
PRO A 325
LEU A 206
ILE A 205
 None
 0.94A 4f4dB-5jjtA:
undetectable		 4f4dB-5jjtA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 7 ASP A 260
ASP A 257
GLU A  61
GLU A 291
 None
NI  A 501 ( 3.1A)
NI  A 503 (-4.3A)
None
 1.22A 4fevD-5jjtA:
undetectable		 4fevD-5jjtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 ASP A 260
ASP A 257
GLU A  61
GLU A 291
 None
NI  A 501 ( 3.1A)
NI  A 503 (-4.3A)
None
 1.17A 4gkhB-5jjtA:
undetectable		 4gkhB-5jjtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 7 ASP A 260
ASP A 257
GLU A  61
GLU A 291
 None
NI  A 501 ( 3.1A)
NI  A 503 (-4.3A)
None
 1.22A 4gkhG-5jjtA:
undetectable		 4gkhG-5jjtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 ASP A 260
ASP A 257
GLU A  61
GLU A 291
 None
NI  A 501 ( 3.1A)
NI  A 503 (-4.3A)
None
 1.22A 4gkiA-5jjtA:
undetectable		 4gkiA-5jjtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 ASP A 260
ASP A 257
GLU A  61
GLU A 291
 None
NI  A 501 ( 3.1A)
NI  A 503 (-4.3A)
None
 1.11A 4gkiC-5jjtA:
undetectable		 4gkiC-5jjtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		3 / 3 ASP A 439
HIS A 467
LYS A 471
 None
 0.90A 4qzuD-5jjtA:
undetectable		 4qzuD-5jjtA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 ILE A 269
LEU A 316
ILE A 151
PHE A 273
 None
 0.67A 4r38A-5jjtA:
undetectable		 4r38A-5jjtA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 GLY A 442
GLN A 440
ASN A 436
HIS A  27
 None
 0.87A 4wryA-5jjtA:
undetectable		 4wryA-5jjtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 GLY A 442
GLN A 440
ASN A 436
HIS A  27
 None
 0.86A 4wrzA-5jjtA:
undetectable		 4wrzA-5jjtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 5 VAL A 259
ASP A 257
PHE A 321
GLY A 288
 None
NI  A 501 ( 3.1A)
None
None
 1.26A 4xp6A-5jjtA:
0.0		 4xp6A-5jjtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 GLY A  88
LEU A 101
ALA A 127
ALA A  93
GLY A  95
 None
 0.86A 5jglB-5jjtA:
undetectable		 5jglB-5jjtA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 5 ILE A 448
ILE A 330
HIS A 328
VAL A 336
 None
 0.94A 5jmnA-5jjtA:
undetectable		 5jmnA-5jjtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 ILE A 268
ILE A 269
PHE A 273
VAL A 229
ASN A 289
 None
None
None
None
NI  A 501 ( 2.9A)
 1.15A 5lg3J-5jjtA:
undetectable		 5lg3J-5jjtA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 8 HIS A 413
ASN A 289
GLY A 389
SER A 384
 NI  A 501 (-3.6A)
NI  A 501 ( 2.9A)
None
None
 0.86A 5m8rC-5jjtA:
undetectable		 5m8rC-5jjtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 8 ASP A 257
ASP A 228
HIS A 230
TRP A 372
HIS A 338
 NI  A 501 ( 3.1A)
NI  A 502 (-3.6A)
NI  A 502 (-3.8A)
None
NI  A 501 (-3.8A)
 1.25A 5nekD-5jjtA:
2.0		 5nekD-5jjtA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		5 / 12 LEU A 206
VAL A 172
LEU A 285
PRO A 246
ILE A 283
 None
 1.18A 5uahC-5jjtA:
undetectable		 5uahC-5jjtA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Arabidopsis
thaliana) 		4 / 5 LEU A 401
LEU A 349
PRO A 325
ARG A 287
 None
 1.03A 6ew0F-5jjtA:
undetectable		 6ew0F-5jjtA:
11.60