SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 128
ALA A 141
LEU A  55
ILE A 129
THR A 140
 None
 1.07A 1d1gB-5jjuA:
undetectable		 1d1gB-5jjuA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.91A 1dhiA-5jjuA:
undetectable		 1dhiA-5jjuA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.92A 1dhiB-5jjuA:
undetectable		 1dhiB-5jjuA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.94A 1dhjA-5jjuA:
undetectable		 1dhjA-5jjuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.93A 1dhjB-5jjuA:
undetectable		 1dhjB-5jjuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.95A 1draB-5jjuA:
undetectable		 1draB-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.97A 1drbA-5jjuA:
undetectable		 1drbA-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.96A 1drbB-5jjuA:
undetectable		 1drbB-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 4 VAL A 291
TRP A 254
TRP A 289
 None
 1.34A 1gmkA-5jjuA:
undetectable
1gmkB-5jjuA:
undetectable		 1gmkA-5jjuA:
4.90
1gmkB-5jjuA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 4 VAL A 291
TRP A 254
TRP A 289
 None
 1.30A 1gmkC-5jjuA:
undetectable
1gmkD-5jjuA:
undetectable		 1gmkC-5jjuA:
4.90
1gmkD-5jjuA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  36
VAL A 155
LEU A  59
LEU A  55
LEU A 159
 None
 1.40A 1mx1E-5jjuA:
1.6		 1mx1E-5jjuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 130
HIS A 312
ASP A 181
 None
A  C1004 ( 3.7A)
MN  A1001 (-2.5A)
 0.82A 1nw5A-5jjuA:
undetectable		 1nw5A-5jjuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.18A 1p7lC-5jjuA:
undetectable		 1p7lC-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.18A 1p7lD-5jjuA:
undetectable		 1p7lD-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.98A 1ra2A-5jjuA:
undetectable		 1ra2A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 1.03A 1ra3A-5jjuA:
undetectable		 1ra3A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.95A 1ra8A-5jjuA:
undetectable		 1ra8A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.94A 1rb2A-5jjuA:
undetectable		 1rb2A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 1.03A 1rb2B-5jjuA:
undetectable		 1rb2B-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 1.02A 1rb3B-5jjuA:
undetectable		 1rb3B-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.94A 1rd7A-5jjuA:
undetectable		 1rd7A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.92A 1re7B-5jjuA:
undetectable		 1re7B-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.19A 1rg9A-5jjuA:
undetectable		 1rg9A-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.18A 1rg9B-5jjuA:
undetectable		 1rg9B-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.18A 1rg9C-5jjuA:
undetectable		 1rg9C-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 132
ASP A 130
SER A 109
ASP A 106
 A  C1004 ( 3.5A)
None
None
MN  A1001 ( 2.6A)
 1.17A 1rg9D-5jjuA:
undetectable		 1rg9D-5jjuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.97A 1rx2A-5jjuA:
undetectable		 1rx2A-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 132
HIS A 312
ASP A 106
HIS A 131
ASP A  47
 A  C1004 ( 3.5A)
A  C1004 ( 3.7A)
MN  A1001 ( 2.6A)
MN  A1001 (-3.5A)
MN  A1001 (-3.2A)
 1.45A 1t69A-5jjuA:
undetectable		 1t69A-5jjuA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.92A 2d0kA-5jjuA:
undetectable		 2d0kA-5jjuA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.98A 2drcB-5jjuA:
undetectable		 2drcB-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 116
LEU A 119
LEU A 101
MET A  95
 None
 0.96A 2oaxF-5jjuA:
undetectable		 2oaxF-5jjuA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 8 SER A 189
SER A 150
THR A 152
LEU A 159
 None
 1.20A 2v0zO-5jjuA:
undetectable		 2v0zO-5jjuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 131
HIS A 312
HIS A 132
 MN  A1001 (-3.5A)
A  C1004 ( 3.7A)
A  C1004 ( 3.5A)
 0.76A 3ag4N-5jjuA:
undetectable		 3ag4N-5jjuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 132
HIS A 312
ASP A 106
ASP A  45
 A  C1004 ( 3.5A)
A  C1004 ( 3.7A)
MN  A1001 ( 2.6A)
MN  A1002 (-2.2A)
 1.10A 3c0zA-5jjuA:
undetectable		 3c0zA-5jjuA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 5 HIS A 132
HIS A 312
ASP A 106
HIS A 131
ASP A  47
 A  C1004 ( 3.5A)
A  C1004 ( 3.7A)
MN  A1001 ( 2.6A)
MN  A1001 (-3.5A)
MN  A1001 (-3.2A)
 1.49A 3c0zA-5jjuA:
undetectable		 3c0zA-5jjuA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 132
HIS A 312
ASP A 106
ASP A  45
 A  C1004 ( 3.5A)
A  C1004 ( 3.7A)
MN  A1001 ( 2.6A)
MN  A1002 (-2.2A)
 1.09A 3c0zC-5jjuA:
undetectable		 3c0zC-5jjuA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 132
HIS A 312
ASP A 106
ASP A  47
 A  C1004 ( 3.5A)
A  C1004 ( 3.7A)
MN  A1001 ( 2.6A)
MN  A1001 (-3.2A)
 1.15A 3c0zC-5jjuA:
undetectable		 3c0zC-5jjuA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 128
ALA A 141
LEU A  55
ILE A 129
THR A 140
 None
 1.08A 3clbA-5jjuA:
2.0		 3clbA-5jjuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.97A 3drcB-5jjuA:
undetectable		 3drcB-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 128
ALA A 141
LEU A  55
ILE A 129
THR A 140
 None
 1.08A 3hbbC-5jjuA:
2.3		 3hbbC-5jjuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 112
ASP A 136
ASP A 111
 A  C1003 ( 3.4A)
None
None
 0.86A 3jayA-5jjuA:
undetectable		 3jayA-5jjuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 131
HIS A 312
HIS A 132
ASP A  45
 MN  A1001 (-3.5A)
A  C1004 ( 3.7A)
A  C1004 ( 3.5A)
MN  A1002 (-2.2A)
 1.14A 3nvcA-5jjuA:
undetectable		 3nvcA-5jjuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 132
HIS A 131
HIS A 312
ASP A  45
 A  C1004 ( 3.5A)
MN  A1001 (-3.5A)
A  C1004 ( 3.7A)
MN  A1002 (-2.2A)
 0.58A 3nvcA-5jjuA:
undetectable		 3nvcA-5jjuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 312
HIS A 132
HIS A 131
ASP A  45
 A  C1004 ( 3.7A)
A  C1004 ( 3.5A)
MN  A1001 (-3.5A)
MN  A1002 (-2.2A)
 1.17A 3nvcA-5jjuA:
undetectable		 3nvcA-5jjuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  52
ALA A  54
ILE A  49
ASP A  45
VAL A 105
 None
None
None
MN  A1002 (-2.2A)
None
 1.15A 3nvkI-5jjuA:
3.0		 3nvkI-5jjuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 THR A 104
ASN A 135
GLY A 139
ALA A 141
ALA A  26
 None
 1.01A 3p5nB-5jjuA:
undetectable		 3p5nB-5jjuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 THR A 104
ASN A 135
GLY A 139
ALA A 141
LEU A  29
 None
 1.00A 3p5nB-5jjuA:
undetectable		 3p5nB-5jjuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.99A 3tq9A-5jjuA:
undetectable		 3tq9A-5jjuA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.97A 4dfrB-5jjuA:
undetectable		 4dfrB-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 129
GLY A  50
GLY A  52
ILE A 174
ALA A 176
 None
 1.08A 4kicB-5jjuA:
3.1		 4kicB-5jjuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  46
ASP A 106
LEU A  80
SER A 259
 None
MN  A1001 ( 2.6A)
None
None
 1.09A 4ot2A-5jjuA:
undetectable		 4ot2A-5jjuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 1.02A 4p66A-5jjuA:
undetectable		 4p66A-5jjuA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
ILE A 158
LEU A  55
ILE A 129
THR A 140
 None
 1.04A 4pstA-5jjuA:
undetectable		 4pstA-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.99A 4pstA-5jjuA:
undetectable		 4pstA-5jjuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.97A 4x5gB-5jjuA:
undetectable		 4x5gB-5jjuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 240
ARG A 242
GLY A 243
GLU A 276
 None
 1.12A 4z2eB-5jjuA:
undetectable
4z2eC-5jjuA:
undetectable		 4z2eB-5jjuA:
21.12
4z2eC-5jjuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 262
SER A 259
TRP A 254
 None
 0.89A 5jwaA-5jjuA:
2.2		 5jwaA-5jjuA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 130
HIS A 131
HIS A 132
HIS A  41
 None
MN  A1001 (-3.5A)
A  C1004 ( 3.5A)
MN  A1002 (-3.5A)
 0.91A 5ncdA-5jjuA:
undetectable
5ncdD-5jjuA:
undetectable		 5ncdA-5jjuA:
20.00
5ncdD-5jjuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 HIS A  41
ASP A 130
HIS A 131
HIS A 132
 MN  A1002 (-3.5A)
None
MN  A1001 (-3.5A)
A  C1004 ( 3.5A)
 0.85A 5ncdB-5jjuA:
undetectable
5ncdC-5jjuA:
undetectable		 5ncdB-5jjuA:
20.00
5ncdC-5jjuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 130
HIS A 131
HIS A 132
HIS A  41
 None
MN  A1001 (-3.5A)
A  C1004 ( 3.5A)
MN  A1002 (-3.5A)
 0.93A 5nelA-5jjuA:
undetectable
5nelD-5jjuA:
undetectable		 5nelA-5jjuA:
20.00
5nelD-5jjuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 0.99A 5z6jA-5jjuA:
undetectable		 5z6jA-5jjuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 141
LEU A 101
LEU A  55
ILE A 129
THR A 140
 None
 1.00A 5z6kA-5jjuA:
undetectable		 5z6kA-5jjuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 335
LEU A 244
ALA A 278
ALA A 279
 None
 0.87A 6a7jA-5jjuA:
undetectable		 6a7jA-5jjuA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5jju UNCHARACTERIZED
PROTEIN RV2837C
(Mycobacterium
tuberculosis) 		6 / 10 ARG A 294
VAL A 277
ALA A 278
LEU A 300
LEU A 331
LEU A 335
 A  C1003 ( 3.0A)
None
None
None
None
None
 1.44A 6f5uA-5jjuA:
undetectable
6f5uB-5jjuA:
undetectable		 6f5uA-5jjuA:
14.19
6f5uB-5jjuA:
12.80