SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1J8U_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 7	VAL A 233 LEU A 236 LEU A 237 PHE A 242 LEU A 243	None	0.61A	1j8uA-5jk6A: 48.0	1j8uA-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1KW0_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	VAL A 123 LEU A 243 TYR A 313 TRP A 314 GLU A 318	None None None None FE A 502 (-2.1A)	1.00A	1kw0A-5jk6A: 41.5	1kw0A-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1KW0_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	10 / 12	VAL A 233 LEU A 236 LEU A 237 PHE A 242 LEU A 243 THR A 254 GLU A 274 HIS A 278 TYR A 313 GLU A 318	None None None None None None None FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.84A	1kw0A-5jk6A: 41.5	1kw0A-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1KW0_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	9 / 12	VAL A 233 PHE A 242 LEU A 243 THR A 254 GLU A 274 HIS A 278 TYR A 313 TRP A 314 GLU A 318	None None None None None FE A 502 (-3.2A) None None FE A 502 (-2.1A)	0.90A	1kw0A-5jk6A: 41.5	1kw0A-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MMK_A_H4BA1427_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	VAL A 123 LEU A 243 TYR A 313 TRP A 314 GLU A 318	None None None None FE A 502 (-2.1A)	0.99A	1mmkA-5jk6A: 41.6	1mmkA-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MMK_A_H4BA1427_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	9 / 12	VAL A 233 LEU A 236 LEU A 237 PHE A 242 LEU A 243 GLU A 274 HIS A 278 TYR A 313 GLU A 318	None None None None None None FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.82A	1mmkA-5jk6A: 41.6	1mmkA-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MMK_A_H4BA1427_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	8 / 12	VAL A 233 PHE A 242 LEU A 243 GLU A 274 HIS A 278 TYR A 313 TRP A 314 GLU A 318	None None None None FE A 502 (-3.2A) None None FE A 502 (-2.1A)	0.87A	1mmkA-5jk6A: 41.6	1mmkA-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MMT_A_H4BA1426_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	6 / 11	LEU A 236 LEU A 237 LEU A 246 HIS A 278 TYR A 313 GLU A 318	None None None FE A 502 (-3.2A) None FE A 502 (-2.1A)	1.49A	1mmtA-5jk6A: 41.4	1mmtA-5jk6A: 47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MMT_A_H4BA1426_1 (PHENYLALANINE-4-HYDR OXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	10 / 11	VAL A 233 LEU A 236 LEU A 237 PHE A 242 LEU A 243 THR A 254 GLU A 274 HIS A 278 TYR A 313 GLU A 318	None None None None None None None FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.79A	1mmtA-5jk6A: 41.4	1mmtA-5jk6A: 47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	PRO A 357 THR A 316 SER A 291 ALA A 391 ALA A 297	None	1.31A	1nw5A-5jk6A: undetectable	1nw5A-5jk6A: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXF_B_DZPB2001_1 (SERUM ALBUMIN)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	LEU A 412 ILE A 411 LEU A 296 GLU A 410 ARG A 401	None	1.13A	2bxfB-5jk6A: undetectable	2bxfB-5jk6A: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_A_CHDA2_0 (FERROCHELATASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 8	LEU A 130 ARG A 147 PRO A 260 SER A 261	None	1.18A	2qd2A-5jk6A: undetectable	2qd2A-5jk6A: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y69_C_CHDC1265_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.30A	2y69C-5jk6A: undetectable 2y69J-5jk6A: undetectable	2y69C-5jk6A: 18.65 2y69J-5jk6A: 10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y69_P_CHDP1265_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.24A	2y69P-5jk6A: undetectable 2y69W-5jk6A: undetectable	2y69P-5jk6A: 18.65 2y69W-5jk6A: 10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGO_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	LEU A 282 ILE A 230 ILE A 218 PHE A 251 VAL A 317	None	0.95A	2ygoA-5jk6A: undetectable	2ygoA-5jk6A: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.30A	3abmC-5jk6A: undetectable 3abmJ-5jk6A: undetectable	3abmC-5jk6A: 18.65 3abmJ-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.26A	3abmP-5jk6A: undetectable 3abmW-5jk6A: undetectable	3abmP-5jk6A: 18.65 3abmW-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.30A	3ag3C-5jk6A: undetectable 3ag3J-5jk6A: undetectable	3ag3C-5jk6A: 18.65 3ag3J-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	3 / 3	ASP A 392 ARG A 388 ALA A 391	None PIN A 501 (-3.1A) None	0.78A	3mbgC-5jk6A: undetectable	3mbgC-5jk6A: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7B_B_HAEB1270_1 (COLLAGENASE 3)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	LEU A 236 HIS A 273 GLU A 274 HIS A 278	None FE A 502 (-3.2A) None FE A 502 (-3.2A)	1.08A	4a7bB-5jk6A: undetectable	4a7bB-5jk6A: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1479_0 (TRANSLATION ELONGATION FACTOR SELB)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	THR A 155 ILE A 152 LYS A 151 GLU A 148	None	1.48A	4acbC-5jk6A: undetectable	4acbC-5jk6A: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQL_A_TXCA1452_2 (GUANINE DEAMINASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	HIS A 158 LEU A 215 LEU A 222 ASP A 217	None	1.19A	4aqlA-5jk6A: undetectable	4aqlA-5jk6A: 24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU8_A_ACTA304_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	3 / 3	ARG A 146 HIS A 134 TYR A 256	None	1.01A	4fu8A-5jk6A: undetectable	4fu8A-5jk6A: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU9_A_ACTA312_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	3 / 3	ARG A 146 HIS A 134 TYR A 256	None	0.96A	4fu9A-5jk6A: undetectable	4fu9A-5jk6A: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NDN_C_SAMC405_0 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 7	HIS A 273 PRO A 269 SER A 291 PHE A 251	FE A 502 (-3.2A) None None None	1.30A	4ndnC-5jk6A: undetectable	4ndnC-5jk6A: 21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PAH_A_LNRA600_1 (PHENYLALANINE HYDROXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 6	LEU A 236 PHE A 242 HIS A 273 TYR A 313 GLU A 318	None None FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.80A	4pahA-5jk6A: 47.9	4pahA-5jk6A: 48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PAH_A_LNRA600_1 (PHENYLALANINE HYDROXYLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 6	PHE A 242 HIS A 273 HIS A 278 TYR A 313 GLU A 318	None FE A 502 (-3.2A) FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.39A	4pahA-5jk6A: 47.9	4pahA-5jk6A: 48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R7L_A_SHHA709_1 (LEUKOTRIENE A-4 HYDROLASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 12	ALA A 239 HIS A 273 GLU A 274 HIS A 278 GLU A 318	None FE A 502 (-3.2A) None FE A 502 (-3.2A) FE A 502 (-2.1A)	0.81A	4r7lA-5jk6A: 2.5	4r7lA-5jk6A: 24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UDA_A_DEXA1985_2 (MINERALOCORTICOID RECEPTOR)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 6	LEU A 116 LEU A 243 PHE A 242 VAL A 233	None	1.04A	4udaA-5jk6A: undetectable	4udaA-5jk6A: 20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_H_TR6H101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	3 / 5	GLY A 277 GLY A 334 GLU A 318	None None FE A 502 (-2.1A)	0.48A	4z2eA-5jk6A: 4.2 4z2eD-5jk6A: undetectable	4z2eA-5jk6A: 21.77 4z2eD-5jk6A: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A1I_A_SAMA405_0 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 7	HIS A 273 PRO A 269 SER A 291 PHE A 251	FE A 502 (-3.2A) None None None	1.33A	5a1iA-5jk6A: undetectable	5a1iA-5jk6A: 21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OY0_B_PQNB1844_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 10	PHE A 242 ARG A 240 ILE A 299 LEU A 243 ALA A 239	None	1.49A	5oy0b-5jk6A: undetectable	5oy0b-5jk6A: 10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5PAH_A_LDPA600_1 (PHENYLALANINE 4-MONOOXYGENASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 4	HIS A 273 HIS A 278 TYR A 313 GLU A 318	FE A 502 (-3.2A) FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.39A	5pahA-5jk6A: 47.5	5pahA-5jk6A: 48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.28A	5wauC-5jk6A: undetectable 5wauJ-5jk6A: undetectable	5wauC-5jk6A: 18.65 5wauJ-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WAU_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.24A	5wauc-5jk6A: undetectable 5wauj-5jk6A: undetectable	5wauc-5jk6A: 18.65 5wauj-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.21A	5xdqC-5jk6A: undetectable 5xdqJ-5jk6A: undetectable	5xdqC-5jk6A: 18.65 5xdqJ-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	PHE A 290 PHE A 287 LEU A 282 PHE A 251	None	1.23A	5xdqP-5jk6A: undetectable 5xdqW-5jk6A: undetectable	5xdqP-5jk6A: 18.65 5xdqW-5jk6A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_A_GLYA717_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 5	SER A 20 ARG A 111 ASP A 69 ARG A 51	None	1.21A	6dwdA-5jk6A: undetectable	6dwdA-5jk6A: 24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FCB_A_SAMA405_0 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 8	HIS A 273 PRO A 269 SER A 291 PHE A 251	FE A 502 (-3.2A) None None None	1.21A	6fcbA-5jk6A: undetectable	6fcbA-5jk6A: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G6R_A_SAMA406_0 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	4 / 7	HIS A 273 PRO A 269 SER A 291 PHE A 251	FE A 502 (-3.2A) None None None	1.33A	6g6rA-5jk6A: undetectable	6g6rA-5jk6A: 21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6PAH_A_DAHA600_1 (PHENYLALANINE 4-MONOOXYGENASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 6	LEU A 236 PRO A 269 HIS A 273 HIS A 278 TYR A 313	None None FE A 502 (-3.2A) FE A 502 (-3.2A) None	0.80A	6pahA-5jk6A: 47.6	6pahA-5jk6A: 48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6PAH_A_DAHA600_1 (PHENYLALANINE 4-MONOOXYGENASE)	5jk6	PHENYLALANINE-4-HYDR OXYLASE (Dictyostelium discoideum)	5 / 6	PRO A 269 HIS A 273 HIS A 278 TYR A 313 GLU A 318	None FE A 502 (-3.2A) FE A 502 (-3.2A) None FE A 502 (-2.1A)	0.42A	6pahA-5jk6A: 47.6	6pahA-5jk6A: 48.04

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1J8U_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"VAL A 233;LEU A 236;LEU A 237;PHE A 242;LEU A 243","None","0.61A","1j8uA-5jk6A:48.0","1j8uA-5jk6A:47.60"],["1KW0_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"VAL A 123;LEU A 243;TYR A 313;TRP A 314;GLU A 318","None;None;None;None; FE A 502 (-2.1A)","1.00A","1kw0A-5jk6A:41.5","1kw0A-5jk6A:47.60"],["1KW0_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",10,"VAL A 233;LEU A 236;LEU A 237;PHE A 242;LEU A 243;THR A 254;GLU A 274;HIS A 278;TYR A 313;GLU A 318","None;None;None;None;None;None;None; FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.84A","1kw0A-5jk6A:41.5","1kw0A-5jk6A:47.60"],["1KW0_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",9,"VAL A 233;PHE A 242;LEU A 243;THR A 254;GLU A 274;HIS A 278;TYR A 313;TRP A 314;GLU A 318","None;None;None;None;None; FE A 502 (-3.2A);None;None; FE A 502 (-2.1A)","0.90A","1kw0A-5jk6A:41.5","1kw0A-5jk6A:47.60"],["1MMK_A_H4BA1427_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"VAL A 123;LEU A 243;TYR A 313;TRP A 314;GLU A 318","None;None;None;None; FE A 502 (-2.1A)","0.99A","1mmkA-5jk6A:41.6","1mmkA-5jk6A:47.60"],["1MMK_A_H4BA1427_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",9,"VAL A 233;LEU A 236;LEU A 237;PHE A 242;LEU A 243;GLU A 274;HIS A 278;TYR A 313;GLU A 318","None;None;None;None;None;None; FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.82A","1mmkA-5jk6A:41.6","1mmkA-5jk6A:47.60"],["1MMK_A_H4BA1427_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",8,"VAL A 233;PHE A 242;LEU A 243;GLU A 274;HIS A 278;TYR A 313;TRP A 314;GLU A 318","None;None;None;None; FE A 502 (-3.2A);None;None; FE A 502 (-2.1A)","0.87A","1mmkA-5jk6A:41.6","1mmkA-5jk6A:47.60"],["1MMT_A_H4BA1426_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",6,"LEU A 236;LEU A 237;LEU A 246;HIS A 278;TYR A 313;GLU A 318","None;None;None; FE A 502 (-3.2A);None; FE A 502 (-2.1A)","1.49A","1mmtA-5jk6A:41.4","1mmtA-5jk6A:47.60"],["1MMT_A_H4BA1426_1","PHENYLALANINE-4-HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",10,"VAL A 233;LEU A 236;LEU A 237;PHE A 242;LEU A 243;THR A 254;GLU A 274;HIS A 278;TYR A 313;GLU A 318","None;None;None;None;None;None;None; FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.79A","1mmtA-5jk6A:41.4","1mmtA-5jk6A:47.60"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"PRO A 357;THR A 316;SER A 291;ALA A 391;ALA A 297","None","1.31A","1nw5A-5jk6A:undetectable","1nw5A-5jk6A:22.40"],["2BXF_B_DZPB2001_1","SERUM ALBUMIN","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"LEU A 412;ILE A 411;LEU A 296;GLU A 410;ARG A 401","None","1.13A","2bxfB-5jk6A:undetectable","2bxfB-5jk6A:21.84"],["2QD2_A_CHDA2_0","FERROCHELATASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"LEU A 130;ARG A 147;PRO A 260;SER A 261","None","1.18A","2qd2A-5jk6A:undetectable","2qd2A-5jk6A:22.07"],["2Y69_C_CHDC1265_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.30A","2y69C-5jk6A:undetectable;2y69J-5jk6A:undetectable","2y69C-5jk6A:18.65;2y69J-5jk6A:10.50"],["2Y69_P_CHDP1265_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.24A","2y69P-5jk6A:undetectable;2y69W-5jk6A:undetectable","2y69P-5jk6A:18.65;2y69W-5jk6A:10.50"],["2YGO_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"LEU A 282;ILE A 230;ILE A 218;PHE A 251;VAL A 317","None","0.95A","2ygoA-5jk6A:undetectable","2ygoA-5jk6A:16.63"],["3ABM_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.30A","3abmC-5jk6A:undetectable;3abmJ-5jk6A:undetectable","3abmC-5jk6A:18.65;3abmJ-5jk6A:11.45"],["3ABM_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.26A","3abmP-5jk6A:undetectable;3abmW-5jk6A:undetectable","3abmP-5jk6A:18.65;3abmW-5jk6A:11.45"],["3AG3_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.30A","3ag3C-5jk6A:undetectable;3ag3J-5jk6A:undetectable","3ag3C-5jk6A:18.65;3ag3J-5jk6A:11.45"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",3,"ASP A 392;ARG A 388;ALA A 391","None;PIN A 501 (-3.1A);None","0.78A","3mbgC-5jk6A:undetectable","3mbgC-5jk6A:17.43"],["4A7B_B_HAEB1270_1","COLLAGENASE 3","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"LEU A 236;HIS A 273;GLU A 274;HIS A 278","None; FE A 502 (-3.2A);None; FE A 502 (-3.2A)","1.08A","4a7bB-5jk6A:undetectable","4a7bB-5jk6A:17.65"],["4ACB_C_DXCC1479_0","TRANSLATION ELONGATION FACTOR SELB","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"THR A 155;ILE A 152;LYS A 151;GLU A 148","None","1.48A","4acbC-5jk6A:undetectable","4acbC-5jk6A:22.16"],["4AQL_A_TXCA1452_2","GUANINE DEAMINASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 158;LEU A 215;LEU A 222;ASP A 217","None","1.19A","4aqlA-5jk6A:undetectable","4aqlA-5jk6A:24.90"],["4FU8_A_ACTA304_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",3,"ARG A 146;HIS A 134;TYR A 256","None","1.01A","4fu8A-5jk6A:undetectable","4fu8A-5jk6A:20.45"],["4FU9_A_ACTA312_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",3,"ARG A 146;HIS A 134;TYR A 256","None","0.96A","4fu9A-5jk6A:undetectable","4fu9A-5jk6A:20.45"],["4NDN_C_SAMC405_0","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 273;PRO A 269;SER A 291;PHE A 251"," FE A 502 (-3.2A);None;None;None","1.30A","4ndnC-5jk6A:undetectable","4ndnC-5jk6A:21.06"],["4PAH_A_LNRA600_1","PHENYLALANINE HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"LEU A 236;PHE A 242;HIS A 273;TYR A 313;GLU A 318","None;None; FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.80A","4pahA-5jk6A:47.9","4pahA-5jk6A:48.04"],["4PAH_A_LNRA600_1","PHENYLALANINE HYDROXYLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"PHE A 242;HIS A 273;HIS A 278;TYR A 313;GLU A 318","None; FE A 502 (-3.2A); FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.39A","4pahA-5jk6A:47.9","4pahA-5jk6A:48.04"],["4R7L_A_SHHA709_1","LEUKOTRIENE A-4 HYDROLASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"ALA A 239;HIS A 273;GLU A 274;HIS A 278;GLU A 318","None; FE A 502 (-3.2A);None; FE A 502 (-3.2A); FE A 502 (-2.1A)","0.81A","4r7lA-5jk6A:2.5","4r7lA-5jk6A:24.38"],["4UDA_A_DEXA1985_2","MINERALOCORTICOID RECEPTOR","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"LEU A 116;LEU A 243;PHE A 242;VAL A 233","None","1.04A","4udaA-5jk6A:undetectable","4udaA-5jk6A:20.05"],["4Z2E_H_TR6H101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",3,"GLY A 277;GLY A 334;GLU A 318","None;None; FE A 502 (-2.1A)","0.48A","4z2eA-5jk6A:4.2;4z2eD-5jk6A:undetectable","4z2eA-5jk6A:21.77;4z2eD-5jk6A:22.59"],["5A1I_A_SAMA405_0","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 273;PRO A 269;SER A 291;PHE A 251"," FE A 502 (-3.2A);None;None;None","1.33A","5a1iA-5jk6A:undetectable","5a1iA-5jk6A:21.06"],["5OY0_B_PQNB1844_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"PHE A 242;ARG A 240;ILE A 299;LEU A 243;ALA A 239","None","1.49A","5oy0b-5jk6A:undetectable","5oy0b-5jk6A:10.71"],["5PAH_A_LDPA600_1","PHENYLALANINE 4-MONOOXYGENASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 273;HIS A 278;TYR A 313;GLU A 318"," FE A 502 (-3.2A); FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.39A","5pahA-5jk6A:47.5","5pahA-5jk6A:48.04"],["5WAU_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.28A","5wauC-5jk6A:undetectable;5wauJ-5jk6A:undetectable","5wauC-5jk6A:18.65;5wauJ-5jk6A:11.45"],["5WAU_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.24A","5wauc-5jk6A:undetectable;5wauj-5jk6A:undetectable","5wauc-5jk6A:18.65;5wauj-5jk6A:11.45"],["5XDQ_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.21A","5xdqC-5jk6A:undetectable;5xdqJ-5jk6A:undetectable","5xdqC-5jk6A:18.65;5xdqJ-5jk6A:11.45"],["5XDQ_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"PHE A 290;PHE A 287;LEU A 282;PHE A 251","None","1.23A","5xdqP-5jk6A:undetectable;5xdqW-5jk6A:undetectable","5xdqP-5jk6A:18.65;5xdqW-5jk6A:11.45"],["6DWD_A_GLYA717_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"SER A  20;ARG A 111;ASP A  69;ARG A  51","None","1.21A","6dwdA-5jk6A:undetectable","6dwdA-5jk6A:24.43"],["6FCB_A_SAMA405_0","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 273;PRO A 269;SER A 291;PHE A 251"," FE A 502 (-3.2A);None;None;None","1.21A","6fcbA-5jk6A:undetectable","6fcbA-5jk6A:21.10"],["6G6R_A_SAMA406_0","S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",4,"HIS A 273;PRO A 269;SER A 291;PHE A 251"," FE A 502 (-3.2A);None;None;None","1.33A","6g6rA-5jk6A:undetectable","6g6rA-5jk6A:21.06"],["6PAH_A_DAHA600_1","PHENYLALANINE 4-MONOOXYGENASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"LEU A 236;PRO A 269;HIS A 273;HIS A 278;TYR A 313","None;None; FE A 502 (-3.2A); FE A 502 (-3.2A);None","0.80A","6pahA-5jk6A:47.6","6pahA-5jk6A:48.04"],["6PAH_A_DAHA600_1","PHENYLALANINE 4-MONOOXYGENASE","5jk6","PHENYLALANINE-4-HYDROXYLASE","Dictyostelium discoideum",5,"PRO A 269;HIS A 273;HIS A 278;TYR A 313;GLU A 318","None; FE A 502 (-3.2A); FE A 502 (-3.2A);None; FE A 502 (-2.1A)","0.42A","6pahA-5jk6A:47.6","6pahA-5jk6A:48.04"]]