SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 VAL D 160
ILE D 173
TYR D 174
GLY D 190
 None
 0.92A 11gsA-5jk7D:
undetectable		 11gsA-5jk7D:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		4 / 6 ILE C1083
ARG C1081
TYR C1387
PHE C1334
 None
 1.49A 1e73M-5jk7C:
undetectable		 1e73M-5jk7C:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		3 / 3 SER C1144
ARG C1145
GLN C1189
 None
 0.96A 2xnrA-5jk7C:
undetectable		 2xnrA-5jk7C:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		3 / 3 PRO D 187
PHE D 284
LYS D 302
 None
 0.97A 3bjwG-5jk7D:
undetectable		 3bjwG-5jk7D:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jk7 PROTEIN VPR
URACIL-DNA
GLYCOSYLASE
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		5 / 12 CYH D 157
LEU D 142
VAL D 140
HIS D 268
TYR F  47
 None
 1.43A 3dzyD-5jk7D:
undetectable		 3dzyD-5jk7D:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		5 / 12 THR C1213
ASN C1216
GLY C1194
HIS C1201
PRO C1217
 None
 1.20A 3eeyD-5jk7C:
undetectable		 3eeyD-5jk7C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 TYR D 147
VAL D 160
ILE D 173
GLY D 190
 None
 0.98A 3gssA-5jk7D:
undetectable		 3gssA-5jk7D:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 TYR D 147
VAL D 160
ILE D 173
GLY D 190
 None
 0.98A 3gssB-5jk7D:
undetectable		 3gssB-5jk7D:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		4 / 6 CYH C1358
THR C1359
CYH C1099
ILE C1354
 None
 1.31A 3w9tB-5jk7C:
undetectable		 3w9tB-5jk7C:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		4 / 4 ASN C1269
GLY C1270
ASP C1256
ASP C1281
 None
 1.31A 4n49A-5jk7C:
undetectable		 4n49A-5jk7C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 10 VAL D 229
VAL D 137
LEU D 201
SER D 237
LEU D 233
 None
 1.01A 4ph9A-5jk7D:
undetectable		 4ph9A-5jk7D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 10 VAL D 229
VAL D 137
LEU D 201
SER D 237
LEU D 233
 None
 1.00A 4ph9B-5jk7D:
undetectable		 4ph9B-5jk7D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 9 ILE D 141
VAL D 140
GLY D 143
ALA D 205
THR D 226
 None
 1.09A 4r21B-5jk7D:
undetectable		 4r21B-5jk7D:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jk7 PROTEIN VPRBP
URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 6 TYR C1131
ASN C1132
GLU C1127
TYR D 116
 None
 1.45A 4twdG-5jk7C:
undetectable
4twdH-5jk7C:
undetectable		 4twdG-5jk7C:
21.33
4twdH-5jk7C:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
PHE D 158
SER D 169
ASN D 204
 None
 0.83A 4wryA-5jk7D:
28.7		 4wryA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
PHE D 158
SER D 169
HIS D 268
 None
 0.97A 4wryA-5jk7D:
28.7		 4wryA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
TYR D 147
PHE D 158
ASN D 204
 None
 0.86A 4wryA-5jk7D:
28.7		 4wryA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 8 GLN D 144
PHE D 158
SER D 169
HIS D 268
 None
 1.04A 4wrzA-5jk7D:
28.0		 4wrzA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 8 GLN D 144
TYR D 147
PHE D 158
HIS D 268
 None
 1.02A 4wrzA-5jk7D:
28.0		 4wrzA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
PHE D 158
SER D 169
ASN D 204
 None
 0.89A 4wrzA-5jk7D:
28.0		 4wrzA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
TYR D 147
PHE D 158
ASN D 204
 None
 0.89A 4wrzA-5jk7D:
28.0		 4wrzA-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 GLY D 143
GLN D 144
TYR D 147
ASN D 204
 None
 0.75A 4ws0A-5jk7D:
28.1		 4ws0A-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 GLY D 143
TYR D 147
PHE D 158
ASN D 204
 None
 0.91A 4ws0A-5jk7D:
28.1		 4ws0A-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 8 GLY D 143
GLN D 144
TYR D 147
PHE D 158
ASN D 204
 None
 1.00A 4ws1A-5jk7D:
28.2		 4ws1A-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 8 GLY D 143
PHE D 158
SER D 169
ASN D 204
 None
 0.75A 4ws1A-5jk7D:
28.2		 4ws1A-5jk7D:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 8 GLY D 143
PHE D 158
SER D 169
HIS D 268
 None
 0.90A 4ws1A-5jk7D:
28.2		 4ws1A-5jk7D:
37.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		4 / 7 ILE D 141
ILE D 173
SER D 169
LEU D 202
 None
 0.71A 5fukA-5jk7D:
undetectable
5fukB-5jk7D:
undetectable		 5fukA-5jk7D:
19.44
5fukB-5jk7D:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens) 		5 / 12 ILE D 299
LEU D 291
VAL D 200
GLY D 199
ASP D 136
 None
 1.25A 5nnaA-5jk7D:
undetectable		 5nnaA-5jk7D:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		4 / 5 VAL C1122
LEU C1110
CYH C1099
ASP C1360
 None
 1.29A 5vcvA-5jk7C:
undetectable		 5vcvA-5jk7C:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		3 / 3 ARG C1247
PHE C1230
ARG C1191
 None
 1.14A 5y9yA-5jk7C:
undetectable		 5y9yA-5jk7C:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5jk7 URACIL-DNA
GLYCOSYLASE
PROTEIN VPR
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		5 / 12 LEU F  23
PRO D 271
HIS F  40
THR D 266
GLY D 246
 None
 1.39A 6mn8A-5jk7F:
undetectable		 6mn8A-5jk7F:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jk7 PROTEIN VPRBP
(Homo
sapiens) 		3 / 3 ARG C1079
LEU C1075
PHE C1071
 None
 0.80A 6nknP-5jk7C:
undetectable		 6nknP-5jk7C:
23.51