SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 ILE A 234
ALA A 141
LEU A 139
LEU A 174
THR A 322
 None
 1.10A 1cd2A-5jknA:
undetectable		 1cd2A-5jknA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		4 / 6 PRO A 127
ILE A 161
ASN A 144
LEU A 140
 None
 1.36A 2wekB-5jknA:
undetectable		 2wekB-5jknA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 10 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.39A 3h9uA-5jknA:
undetectable		 3h9uA-5jknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 10 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.42A 3h9uB-5jknA:
undetectable		 3h9uB-5jknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 10 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.41A 3h9uC-5jknA:
undetectable		 3h9uC-5jknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 10 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.41A 3h9uD-5jknA:
undetectable		 3h9uD-5jknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 PHE A 229
THR A 223
PRO A 138
GLY A 207
LEU A 208
 None
 1.18A 3j6pB-5jknA:
undetectable		 3j6pB-5jknA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 PHE A 364
LEU A 332
GLU A 308
ALA A 306
LEU A 302
 None
 0.94A 5iepA-5jknA:
undetectable		 5iepA-5jknA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 PHE A 229
THR A 223
PRO A 138
GLY A 207
LEU A 208
 None
 1.02A 5ogcB-5jknA:
undetectable		 5ogcB-5jknA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 LEU A 281
GLY A 280
SER A 246
VAL A 242
VAL A 253
 None
 1.17A 6bxlB-5jknA:
undetectable		 6bxlB-5jknA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5jkn PROTEIN FAM63A
(Homo
sapiens) 		5 / 12 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.42A 6exiA-5jknA:
undetectable		 6exiA-5jknA:
15.88