SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jkq PFVFT1
(Plasmodium
falciparum) 		5 / 12 ILE A 193
LEU A  71
ALA A  40
LEU A 190
ILE A 192
 None
 1.00A 1g5yB-5jkqA:
undetectable		 1g5yB-5jkqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 7 LEU A 262
SER A 260
LEU A 257
ALA A 226
 None
 0.89A 1j8uA-5jkqA:
undetectable		 1j8uA-5jkqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		5 / 12 LEU A 236
PHE A 240
LEU A 290
ILE A 267
SER A 196
 None
 1.23A 2hrcA-5jkqA:
undetectable		 2hrcA-5jkqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jkq PFVFT1
(Plasmodium
falciparum) 		5 / 12 LEU A 236
PHE A 240
LEU A 290
ILE A 267
SER A 196
 None
 1.37A 2pnjB-5jkqA:
undetectable		 2pnjB-5jkqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 8 ILE A 274
SER A 288
ASP A  61
SER A 272
 None
 1.13A 2zw9B-5jkqA:
undetectable		 2zw9B-5jkqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 7 ILE A 127
ILE A 128
VAL A  42
LEU A  45
 None
 0.70A 3r9vA-5jkqA:
undetectable
3r9vB-5jkqA:
undetectable		 3r9vA-5jkqA:
23.35
3r9vB-5jkqA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5jkq PFVFT1
(Plasmodium
falciparum) 		3 / 3 ASN A  29
ALA A 301
LYS A  30
 None
 0.90A 3runA-5jkqA:
undetectable		 3runA-5jkqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 5 LEU A 257
ILE A 274
PRO A 275
PHE A 276
 None
 1.08A 3s3vA-5jkqA:
undetectable		 3s3vA-5jkqA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		5 / 9 ILE A 267
ALA A 226
LEU A 257
ILE A 283
ILE A 201
 None
 1.18A 3tq8A-5jkqA:
undetectable		 3tq8A-5jkqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5jkq PFVFT1
(Plasmodium
falciparum) 		3 / 3 TYR A  38
GLU A 130
TYR A 126
 None
 0.97A 3ug8A-5jkqA:
undetectable		 3ug8A-5jkqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 4 LYS A 299
LEU A 186
ALA A 300
VAL A  27
 None
 1.25A 4ik6A-5jkqA:
undetectable		 4ik6A-5jkqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 5 SER A 260
VAL A 261
GLY A 269
ALA A 226
 None
 1.05A 5k50A-5jkqA:
undetectable		 5k50A-5jkqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5jkq PFVFT1
(Plasmodium
falciparum) 		4 / 4 ASN A 220
LEU A 223
SER A 218
LEU A 213
 None
 1.13A 5kb5A-5jkqA:
undetectable		 5kb5A-5jkqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5jkq PFVFT1
(Plasmodium
falciparum) 		5 / 12 LEU A  51
GLY A 119
ILE A 192
ALA A 296
GLU A 130
 None
 1.05A 5veuH-5jkqA:
undetectable		 5veuH-5jkqA:
21.75