SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  22
LEU A  29
VAL A  36
ALA A  89
ASN A  87
 None
None
None
NAD  A 401 (-3.6A)
None
 1.14A 1fpqA-5jlaA:
6.3		 1fpqA-5jlaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 4 THR A 188
GLY A  18
ASP A  40
ALA A  89
 NAD  A 401 (-2.5A)
NAD  A 401 ( 4.0A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.6A)
 1.25A 1sg9A-5jlaA:
6.3		 1sg9A-5jlaA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 11 GLY A  16
SER A  19
ASP A  40
ASP A  61
VAL A  62
ALA A  89
VAL A  91
 NAD  A 401 (-3.5A)
NAD  A 401 (-2.7A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
NAD  A 401 (-3.6A)
None
 0.65A 1uayA-5jlaA:
30.5		 1uayA-5jlaA:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 10 GLY A  16
SER A  19
ASP A  40
ASP A  61
VAL A  62
ALA A  89
VAL A  91
 NAD  A 401 (-3.5A)
NAD  A 401 (-2.7A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
NAD  A 401 (-3.6A)
None
 0.69A 1uayB-5jlaA:
30.8		 1uayB-5jlaA:
31.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  16
ASP A  40
ARG A  41
ASP A  61
ALA A  89
 NAD  A 401 (-3.5A)
NAD  A 401 (-2.9A)
NAD  A 401 (-3.0A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.63A 2bm9E-5jlaA:
4.7		 2bm9E-5jlaA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  16
GLY A  18
ASP A  42
ASP A  61
ILE A 112
 NAD  A 401 (-3.5A)
NAD  A 401 ( 4.0A)
None
NAD  A 401 (-3.7A)
NAD  A 401 (-4.0A)
 0.85A 3fuuA-5jlaA:
5.0		 3fuuA-5jlaA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		3 / 3 GLU A  27
GLU A 222
ASN A 218
 None
 0.79A 3lp9B-5jlaA:
undetectable
3lp9D-5jlaA:
undetectable		 3lp9B-5jlaA:
21.71
3lp9D-5jlaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 5 SER A 141
ILE A  21
TYR A 153
GLY A 184
 NAD  A 401 (-3.3A)
NAD  A 401 (-3.8A)
NAD  A 401 (-4.4A)
NAD  A 401 (-4.9A)
 1.05A 3uboB-5jlaA:
6.1		 3uboB-5jlaA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 11 GLY A  18
ASP A  40
ASP A  42
ASP A  61
VAL A  62
 NAD  A 401 ( 4.0A)
NAD  A 401 (-2.9A)
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.77A 3v8vB-5jlaA:
7.1		 3v8vB-5jlaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 THR A 117
MET A 128
GLY A 125
PRO A 127
ALA A  82
 None
 1.12A 4ypmA-5jlaA:
undetectable		 4ypmA-5jlaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 ARG A  48
ILE A  21
GLY A  22
GLU A  27
ALA A 217
 None
NAD  A 401 (-3.8A)
None
None
None
 0.90A 5o96C-5jlaA:
2.8
5o96D-5jlaA:
2.5		 5o96C-5jlaA:
25.61
5o96D-5jlaA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 ILE A  21
GLY A  22
GLU A  27
GLY A  18
ALA A 217
 NAD  A 401 (-3.8A)
None
None
NAD  A 401 ( 4.0A)
None
 0.78A 5o96C-5jlaA:
2.8
5o96D-5jlaA:
2.5		 5o96C-5jlaA:
25.61
5o96D-5jlaA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 ASP A  61
ARG A  41
LEU A  60
ASP A  40
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.0A)
None
NAD  A 401 (-2.9A)
 1.20A 5tdzA-5jlaA:
undetectable		 5tdzA-5jlaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 205
LEU A 191
LEU A 200
GLY A 154
LEU A 150
 None
NAD  A 401 ( 4.4A)
None
None
None
 0.99A 6b0cD-5jlaA:
5.7		 6b0cD-5jlaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 6 GLU A   6
ARG A 231
PHE A 226
VAL A 224
 None
 1.28A 6fgdA-5jlaA:
undetectable		 6fgdA-5jlaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 VAL A  68
VAL A  62
PHE A 124
ILE A 136
ASN A  87
 None
NAD  A 401 (-3.6A)
None
None
None
 1.47A 6mxtA-5jlaA:
undetectable		 6mxtA-5jlaA:
21.04