SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 6 ASN A 307
ALA A 306
GLY A 264
TYR A 266
 None
 1.07A 1c8lA-5jlcA:
undetectable		 1c8lA-5jlcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 8 TYR A 127
PHE A 242
PHE A 237
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.5A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.7A)
 1.29A 1ea1A-5jlcA:
33.1		 1ea1A-5jlcA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 ASP A 391
ASP A  55
ASP A 404
 None
 0.56A 1eizA-5jlcA:
undetectable		 1eizA-5jlcA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 ASP A 391
ASP A  55
ASP A 404
 None
 0.56A 1ej0A-5jlcA:
undetectable		 1ej0A-5jlcA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 9 VAL A 312
LEU A 159
ALA A 209
SER A 212
LEU A 213
 1YN  A 602 ( 4.3A)
None
None
None
None
 1.19A 1eqgA-5jlcA:
undetectable		 1eqgA-5jlcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 6 ASN A 307
ALA A 306
GLY A 264
TYR A 266
 None
 1.08A 1gfzA-5jlcA:
undetectable		 1gfzA-5jlcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 CYH A 480
LEU A 367
ILE A 488
PHE A 164
ILE A 171
 None
 1.43A 1i18A-5jlcA:
undetectable
1i18B-5jlcA:
undetectable		 1i18A-5jlcA:
14.45
1i18B-5jlcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 8 TYR A 127
PHE A 242
PHE A 237
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.5A)
1YN  A 602 (-4.5A)
HEM  A 601 (-3.6A)
 1.04A 1x8vA-5jlcA:
34.6		 1x8vA-5jlcA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 6 LEU A 367
GLY A 483
LEU A 356
ILE A 488
 None
 0.91A 1yajF-5jlcA:
undetectable		 1yajF-5jlcA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 GLN A 259
LYS A 137
VAL A 139
 None
 0.92A 2jfaB-5jlcA:
1.9		 2jfaB-5jlcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 LEU A 309
LEU A 313
MET A 218
LEU A 269
THR A 265
 None
None
None
1PE  A 604 ( 4.3A)
1PE  A 604 (-3.5A)
 1.25A 2q7kA-5jlcA:
2.6		 2q7kA-5jlcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 PHE A 135
THR A 319
LEU A 381
MET A 512
VAL A 513
 1YN  A 602 ( 4.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
None
 1.08A 2wuzA-5jlcA:
39.6		 2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 PHE A 135
TYR A 141
THR A 319
LEU A 381
VAL A 513
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
 0.95A 2wuzA-5jlcA:
39.6		 2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 TYR A 127
TYR A 141
THR A 319
LEU A 381
VAL A 513
 1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
 0.93A 2wuzA-5jlcA:
39.6		 2wuzA-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 PHE A 135
THR A 319
LEU A 381
MET A 512
VAL A 513
 1YN  A 602 ( 4.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
None
 1.12A 2wuzB-5jlcA:
39.5		 2wuzB-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 PHE A 135
TYR A 141
THR A 319
LEU A 381
VAL A 513
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
 0.96A 2wuzB-5jlcA:
39.5		 2wuzB-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 TYR A 127
TYR A 141
THR A 319
LEU A 381
VAL A 513
 1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
None
 0.94A 2wuzB-5jlcA:
39.5		 2wuzB-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 7 PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.44A 2wx2A-5jlcA:
37.4		 2wx2A-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 8 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.51A 2wx2B-5jlcA:
35.9		 2wx2B-5jlcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A 127
PHE A 135
PRO A 239
THR A 319
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-3.5A)
 1.29A 2x2nA-5jlcA:
38.9		 2x2nA-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 TYR A 127
PHE A 242
TYR A 141
PRO A 239
THR A 319
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.5A)
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-3.5A)
 1.31A 2x2nA-5jlcA:
38.9		 2x2nA-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 PHE A 135
PRO A 239
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 4.6A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 1.08A 2x2nC-5jlcA:
37.4		 2x2nC-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 PHE A 242
TYR A 141
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 4.5A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 1.11A 2x2nC-5jlcA:
37.4		 2x2nC-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A 141
PRO A 239
THR A 319
LEU A 381
MET A 512
 HEM  A 601 (-4.2A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.94A 2x2nC-5jlcA:
37.4		 2x2nC-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 ILE A  71
TYR A 127
PHE A 135
LEU A 381
MET A 512
 1YN  A 602 ( 4.9A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 1.12A 2x2nD-5jlcA:
39.2		 2x2nD-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 ILE A  71
TYR A 127
TYR A 141
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.68A 2x2nD-5jlcA:
39.2		 2x2nD-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 TYR A 127
PHE A 242
TYR A 141
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.5A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 1.09A 2x2nD-5jlcA:
39.2		 2x2nD-5jlcA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 6 ASN A 307
ALA A 306
GLY A 264
TYR A 266
 None
 1.10A 3dd1B-5jlcA:
undetectable		 3dd1B-5jlcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 GLN A 338
THR A 492
PHE A 179
VAL A 197
LEU A 329
 None
 1.32A 3elzC-5jlcA:
undetectable		 3elzC-5jlcA:
13.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 8 TYR A 127
THR A 131
TYR A 141
GLY A 311
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
HEM  A 601 (-4.2A)
1YN  A 602 (-3.9A)
HEM  A 601 ( 3.5A)
 0.69A 3jusA-5jlcA:
44.6		 3jusA-5jlcA:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 8 TYR A 127
THR A 131
TYR A 141
GLY A 311
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
HEM  A 601 (-4.2A)
1YN  A 602 (-3.9A)
HEM  A 601 ( 3.5A)
 0.69A 3jusA-5jlcA:
44.6		 3jusA-5jlcA:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 9 TYR A 127
THR A 131
TYR A 141
GLY A 311
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
HEM  A 601 (-4.2A)
1YN  A 602 (-3.9A)
HEM  A 601 ( 3.5A)
 0.61A 3jusB-5jlcA:
44.4		 3jusB-5jlcA:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 8 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.68A 3khmA-5jlcA:
38.6		 3khmA-5jlcA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 9 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.92A 3l4dB-5jlcA:
37.7		 3l4dB-5jlcA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 9 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.86A 3l4dC-5jlcA:
38.8		 3l4dC-5jlcA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 8 PHE A 135
TYR A 141
LEU A 381
MET A 512
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.71A 3l4dD-5jlcA:
39.3		 3l4dD-5jlcA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 8 PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.67A 3l4dD-5jlcA:
39.3		 3l4dD-5jlcA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 TYR A 127
PHE A 135
TYR A 141
PHE A 237
GLY A 311
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 (-3.9A)
HEM  A 601 ( 3.5A)
 0.75A 3ld6A-5jlcA:
45.1		 3ld6A-5jlcA:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 TYR A 127
PHE A 135
TYR A 141
PHE A 237
GLY A 311
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 (-3.9A)
HEM  A 601 ( 3.5A)
 0.78A 3ld6B-5jlcA:
44.9		 3ld6B-5jlcA:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 HIS A 470
ARG A 386
GLU A 124
 HEM  A 601 (-3.6A)
HEM  A 601 (-3.0A)
None
 1.18A 3qf1A-5jlcA:
undetectable		 3qf1A-5jlcA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 5 ILE A 140
THR A 131
THR A 132
SER A 128
 1YN  A 602 (-4.4A)
1YN  A 602 ( 4.9A)
None
None
 1.07A 3snfA-5jlcA:
undetectable		 3snfA-5jlcA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 TYR A 405
LEU A 118
LYS A 117
 None
 0.68A 3sueD-5jlcA:
undetectable		 3sueD-5jlcA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 ASP A  55
ARG A  53
ASP A 391
 None
 0.85A 4fzvA-5jlcA:
undetectable		 4fzvA-5jlcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 8 GLU A  82
GLU A 418
GLU A 419
GLN A 417
 None
 0.91A 4mj8A-5jlcA:
undetectable		 4mj8A-5jlcA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 MET A 300
GLU A 304
LEU A 308
 None
 0.48A 4v2oB-5jlcA:
1.1		 4v2oB-5jlcA:
10.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		9 / 9 TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
THR A 319
LEU A 381
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.73A 4wmzA-5jlcA:
59.2		 4wmzA-5jlcA:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 ALA A 332
LEU A 329
THR A 517
ALA A 520
VAL A 195
 None
 1.23A 4x1iB-5jlcA:
undetectable		 4x1iB-5jlcA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 7 VAL A 458
ILE A 454
HIS A 379
LEU A 384
 None
None
None
HEM  A 601 (-3.6A)
 1.22A 4xo7B-5jlcA:
undetectable		 4xo7B-5jlcA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.52A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 GLY A 316
THR A 319
LEU A 381
HIS A 382
THR A 510
MET A 512
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.95A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 ALA A  70
TYR A  73
PRO A 239
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
 0.07A 4zdyA-5jlcA:
59.6		 4zdyA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 7 PHE A 135
ILE A 140
PHE A 237
GLY A 315
LEU A 381
MET A 512
 1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.77A 4zdzA-5jlcA:
59.0		 4zdzA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 7 PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
 1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.60A 4zdzA-5jlcA:
59.0		 4zdzA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		9 / 9 TYR A 127
THR A 131
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.58A 4ze0A-5jlcA:
59.2		 4ze0A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		11 / 12 TYR A  73
GLY A  74
LEU A 130
PHE A 135
PHE A 237
GLY A 315
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.62A 4ze1A-5jlcA:
58.8		 4ze1A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 5 TYR A 127
ILE A 140
PRO A 239
THR A 319
 1YN  A 602 ( 3.8A)
1YN  A 602 (-4.4A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
 0.37A 4ze1A-5jlcA:
undetectable		 4ze1A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.69A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 GLY A 316
THR A 319
LEU A 381
HIS A 382
THR A 510
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
 0.98A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 5 ALA A  70
TYR A  73
PRO A 239
PHE A 385
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
1YN  A 602 (-4.8A)
 0.26A 4ze2A-5jlcA:
58.9		 4ze2A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		7 / 7 TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.61A 4ze3A-5jlcA:
59.0		 4ze3A-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 GLY A  74
GLY A 316
LEU A 381
HIS A 382
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
HEM  A 601 (-3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.83A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 311
GLY A 315
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 (-3.9A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.38A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EQB_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 4 TYR A  73
TYR A 127
PRO A 239
THR A 319
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.8A)
HEM  A 601 ( 3.5A)
 0.28A 5eqbA-5jlcA:
59.7		 5eqbA-5jlcA:
84.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		11 / 12 TYR A  73
PHE A 135
ILE A 140
TYR A 141
PHE A 237
VAL A 243
GLY A 315
THR A 319
LEU A 381
HIS A 382
MET A 512
 1YN  A 602 (-4.9A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
None
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.5A)
 0.57A 5esgA-5jlcA:
59.1		 5esgA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 4 LEU A  97
TYR A 127
PRO A 239
ILE A 240
 None
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.8A)
None
 0.65A 5esgA-5jlcA:
59.1		 5esgA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		8 / 12 ALA A  70
LEU A  96
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
MET A 512
 1YN  A 602 (-3.4A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 (-3.5A)
 1.44A 5eshA-5jlcA:
59.1		 5eshA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		8 / 12 ALA A  70
LEU A  97
PHE A 237
GLY A 315
THR A 319
LEU A 381
PHE A 385
MET A 512
 1YN  A 602 (-3.4A)
None
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.5A)
 0.83A 5eshA-5jlcA:
59.1		 5eshA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		11 / 12 ALA A  70
LEU A  97
TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
THR A 319
LEU A 381
MET A 512
 1YN  A 602 (-3.4A)
None
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.5A)
 0.73A 5eshA-5jlcA:
59.1		 5eshA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
TYR A 127
LEU A 130
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
THR A 319
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.72A 5eskA-5jlcA:
57.6		 5eskA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 4 ALA A  70
PRO A 239
LEU A 381
HIS A 382
 1YN  A 602 (-3.4A)
1YN  A 602 ( 4.8A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
 0.28A 5eskA-5jlcA:
57.6		 5eskA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
GLY A 315
THR A 319
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.53A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 GLY A 316
THR A 319
HIS A 382
THR A 510
MET A 512
 HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 1.05A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 5 ALA A  70
TYR A  73
PRO A 239
GLY A 311
LEU A 381
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 4.8A)
1YN  A 602 (-3.9A)
1YN  A 602 ( 4.7A)
 0.29A 5eslA-5jlcA:
59.3		 5eslA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 7 TYR A 127
PHE A 135
ILE A 140
GLY A 315
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.55A 5esmA-5jlcA:
58.3		 5esmA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 7 TYR A 127
PHE A 135
ILE A 140
PHE A 237
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.54A 5esmA-5jlcA:
58.3		 5esmA-5jlcA:
83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 ALA A  70
TYR A  73
TYR A 127
LEU A 130
PHE A 135
ILE A 140
PHE A 237
PHE A 242
GLY A 315
LEU A 381
HIS A 382
PHE A 385
 1YN  A 602 (-3.4A)
1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.5A)
1YN  A 602 ( 3.6A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
 0.72A 5fsaA-5jlcA:
54.7		 5fsaA-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 LEU A 130
TYR A 127
PHE A 237
GLY A 315
THR A 319
 None
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
 1.26A 5fsaB-5jlcA:
52.0		 5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A  73
GLY A  74
GLY A 316
THR A 319
HIS A 382
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-3.5A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
 1.04A 5fsaB-5jlcA:
52.0		 5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		10 / 12 TYR A  73
GLY A  74
LEU A 130
PHE A 135
TYR A 141
PHE A 237
GLY A 315
THR A 319
HIS A 382
PHE A 385
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
None
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
 0.68A 5fsaB-5jlcA:
52.0		 5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 12 TYR A  73
GLY A  74
TYR A 141
ILE A 473
HIS A 382
PHE A 385
 1YN  A 602 (-4.9A)
1YN  A 602 ( 3.8A)
HEM  A 601 (-4.2A)
HEM  A 601 (-4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
 1.39A 5fsaB-5jlcA:
52.0		 5fsaB-5jlcA:
62.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		8 / 8 TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.41A 5hs1A-5jlcA:
49.2		 5hs1A-5jlcA:
84.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 6 TYR A 533
ILE A 490
ARG A 527
TYR A 342
 None
 1.37A 5igyA-5jlcA:
undetectable		 5igyA-5jlcA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 PHE A 135
TYR A 141
THR A 319
LEU A 381
THR A 510
 1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-3.8A)
 0.93A 5tl8A-5jlcA:
42.4		 5tl8A-5jlcA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 PHE A 135
TYR A 127
PHE A 237
GLY A 315
THR A 319
 1YN  A 602 ( 4.6A)
1YN  A 602 ( 3.8A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
 1.16A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A 127
ILE A 140
TYR A 141
PHE A 242
LEU A 384
 1YN  A 602 ( 3.8A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.5A)
HEM  A 601 (-3.6A)
 1.21A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 TYR A 127
PHE A 135
ILE A 140
TYR A 141
PHE A 237
PHE A 242
GLY A 315
THR A 319
LEU A 381
HIS A 382
PHE A 385
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.5A)
 0.66A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 GLY A  74
THR A 131
PRO A 239
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.9A)
1YN  A 602 ( 4.8A)
 0.39A 5v5zA-5jlcA:
53.5		 5v5zA-5jlcA:
62.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		3 / 3 MET A 289
ASP A 278
ARG A 211
 None
 1.19A 5z6jA-5jlcA:
undetectable		 5z6jA-5jlcA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 10 TYR A 127
PHE A 135
TYR A 141
PHE A 237
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 4.7A)
 1.31A 6ay4A-5jlcA:
42.3		 6ay4A-5jlcA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 10 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
CYH A 472
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-2.3A)
 0.62A 6ay4A-5jlcA:
42.3		 6ay4A-5jlcA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		6 / 9 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
CYH A 472
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
HEM  A 601 (-2.3A)
 0.50A 6ay6A-5jlcA:
42.2		 6ay6A-5jlcA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.53A 6aybA-5jlcA:
40.9		 6aybA-5jlcA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 TYR A 127
PHE A 135
TYR A 141
THR A 319
LEU A 381
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
HEM  A 601 (-4.2A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
 0.50A 6aycA-5jlcA:
42.5		 6aycA-5jlcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 ILE A 113
SER A 455
HIS A 110
LEU A 384
LEU A 463
 None
None
None
HEM  A 601 (-3.6A)
None
 1.02A 6chgC-5jlcA:
undetectable		 6chgC-5jlcA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 4 VAL A 134
GLY A 236
ASP A 234
ASP A 232
 None
 1.14A 6cjkC-5jlcA:
undetectable		 6cjkC-5jlcA:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		12 / 12 GLY A  74
TYR A 127
PHE A 135
ILE A 140
PHE A 237
GLY A 315
THR A 319
LEU A 381
HIS A 382
PHE A 385
THR A 510
MET A 512
 1YN  A 602 ( 3.8A)
1YN  A 602 ( 3.8A)
1YN  A 602 ( 4.6A)
1YN  A 602 (-4.4A)
1YN  A 602 (-4.5A)
1YN  A 602 ( 3.6A)
HEM  A 601 ( 3.5A)
1YN  A 602 ( 4.7A)
1YN  A 602 (-4.2A)
1YN  A 602 (-4.8A)
1YN  A 602 (-3.8A)
1YN  A 602 (-3.5A)
 0.60A 6e8qA-5jlcA:
58.9		 6e8qA-5jlcA:
77.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E8Q_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		4 / 4 TYR A  73
LEU A 130
TYR A 141
PRO A 239
 1YN  A 602 (-4.9A)
None
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.8A)
 0.70A 6e8qA-5jlcA:
58.9		 6e8qA-5jlcA:
77.42