SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 CYH A 340
LEU A 535
SER A 157
VAL A 375
ILE A 526
 None
 1.30A 1ee2A-5jldA:
5.5		 1ee2A-5jldA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 CYH A 340
LEU A 535
SER A 157
VAL A 375
ILE A 526
 None
 1.31A 1ee2B-5jldA:
2.6		 1ee2B-5jldA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 GLU A 580
LEU A 574
LEU A 577
LEU A 575
 None
 0.92A 1np1A-5jldA:
undetectable		 1np1A-5jldA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 HIS A 145
GLY A 147
HIS A 148
GLN A 349
VAL A 380
 None
 0.84A 1qu2A-5jldA:
11.6		 1qu2A-5jldA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 TYR A 538
LEU A 577
MET A   4
ILE A 116
 None
 0.86A 1tuvA-5jldA:
undetectable		 1tuvA-5jldA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 9 ASP A 134
GLN A 349
PHE A 353
THR A 345
LEU A 310
 None
 1.31A 1zp4A-5jldA:
0.8		 1zp4A-5jldA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_B_C2FB996_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 ASP A 134
GLN A 349
PHE A 353
THR A 345
LEU A 310
 None
 1.34A 1zp4B-5jldA:
0.5		 1zp4B-5jldA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 416
THR A 472
VAL A 468
 None
 0.96A 2q64A-5jldA:
undetectable		 2q64A-5jldA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 LEU A 310
TYR A 301
GLN A 302
 None
 0.69A 2wekA-5jldA:
3.6		 2wekA-5jldA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ILE A 114
ASP A 113
ILE A 516
ILE A 570
SER A 569
 None
 1.16A 3kpbA-5jldA:
undetectable		 3kpbA-5jldA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ILE A 121
ILE A 116
PHE A 519
VAL A 161
 None
 0.82A 4acaC-5jldA:
3.2		 4acaC-5jldA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 4 ILE A 118
LEU A 165
LYS A 166
ASN A 117
 None
 1.27A 4g19D-5jldA:
undetectable		 4g19D-5jldA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 ILE A 360
VAL A 282
VAL A 326
TRP A 365
 None
 0.95A 5jwaH-5jldA:
3.3		 5jwaH-5jldA:
23.04