SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_E_TFPE212_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5jlv	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	4 / 7	PHE C 542 PHE C 507 PHE C 547 SER C 555	None	1.08A	1wrlE-5jlvC: undetectable	1wrlE-5jlvC: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJJ_B_NCTB501_1 (CYTOCHROME P450 2A6)	5jlv	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	4 / 7	PHE C 522 VAL C 505 PHE C 517 PHE C 532	None	0.97A	4ejjB-5jlvC: undetectable	4ejjB-5jlvC: 13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V5Z_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5jlv	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	5 / 12	TYR C 497 PHE C 537 PHE C 522 PHE C 481 THR C 530	None	1.43A	5v5zA-5jlvC: undetectable	5v5zA-5jlvC: 11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HUO_D_08HD501_0 (GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOB UTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2)	5jlv	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	4 / 8	PHE C 532 PHE C 522 SER C 515 TYR C 497	None	1.11A	6huoC-5jlvC: undetectable 6huoD-5jlvC: undetectable	6huoC-5jlvC: 20.17 6huoD-5jlvC: 20.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRL_E_TFPE212_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5jlv","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",4,"PHE C 542;PHE C 507;PHE C 547;SER C 555","None","1.08A","1wrlE-5jlvC:undetectable","1wrlE-5jlvC:18.03"],["4EJJ_B_NCTB501_1","CYTOCHROME P450 2A6","5jlv","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",4,"PHE C 522;VAL C 505;PHE C 517;PHE C 532","None","0.97A","4ejjB-5jlvC:undetectable","4ejjB-5jlvC:13.88"],["5V5Z_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5jlv","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",5,"TYR C 497;PHE C 537;PHE C 522;PHE C 481;THR C 530","None","1.43A","5v5zA-5jlvC:undetectable","5v5zA-5jlvC:11.69"],["6HUO_D_08HD501_0","GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2","5jlv","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",4,"PHE C 532;PHE C 522;SER C 515;TYR C 497","None","1.11A","6huoC-5jlvC:undetectable;6huoD-5jlvC:undetectable","6huoC-5jlvC:20.17;6huoD-5jlvC:20.34"]]