SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 HIS A 485
ALA A 162
GLU A 339
HIS A 133
ASP A 306
 ZN  A 601 (-3.0A)
None
ZN  A 602 (-3.5A)
ZN  A 602 (-3.3A)
ZN  A 601 ( 2.1A)
 1.43A 1a4lD-5jm6A:
undetectable		 1a4lD-5jm6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.33A 1usqB-5jm6A:
undetectable		 1usqB-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.33A 1usqC-5jm6A:
undetectable		 1usqC-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.36A 1usqD-5jm6A:
undetectable		 1usqD-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.34A 1usqE-5jm6A:
undetectable		 1usqE-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A 353
ARG A 346
SER A 111
THR A 105
 None
 0.89A 2f7fA-5jm6A:
undetectable		 2f7fA-5jm6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.41A 2jkjA-5jm6A:
undetectable		 2jkjA-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.40A 2jkjB-5jm6A:
undetectable		 2jkjB-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.40A 2jkjC-5jm6A:
undetectable		 2jkjC-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 PRO A  51
PRO A 496
ILE A 479
GLY A 499
 None
 1.15A 2jkjD-5jm6A:
undetectable		 2jkjD-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 PRO A  51
PRO A 496
ILE A 479
GLY A 499
 None
 1.16A 2jkjF-5jm6A:
undetectable		 2jkjF-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 6 PRO A  51
GLY A 497
PRO A 496
ILE A 479
GLY A 499
 None
 1.40A 2jklB-5jm6A:
undetectable		 2jklB-5jm6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR A  58
LEU A 309
ASP A 307
SER A 390
 None
None
ZN  A 602 ( 4.3A)
None
 1.34A 3lslA-5jm6A:
undetectable
3lslD-5jm6A:
undetectable		 3lslA-5jm6A:
18.52
3lslD-5jm6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 SER A 390
TYR A  58
LEU A 309
ASP A 307
 None
None
None
ZN  A 602 ( 4.3A)
 1.29A 3lslA-5jm6A:
undetectable
3lslD-5jm6A:
undetectable		 3lslA-5jm6A:
18.52
3lslD-5jm6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 264
VAL A 176
VAL A 195
GLY A 177
TRP A 199
 None
 1.28A 3mecA-5jm6A:
undetectable		 3mecA-5jm6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 264
VAL A 176
VAL A 195
GLY A 177
TRP A 199
 None
 1.26A 3medA-5jm6A:
undetectable
3medB-5jm6A:
undetectable		 3medA-5jm6A:
22.24
3medB-5jm6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LEU A 319
HIS A 320
MET A 316
 None
 0.90A 3thrD-5jm6A:
undetectable		 3thrD-5jm6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 HIS A 394
HIS A 450
ILE A 452
 None
 0.73A 3u52A-5jm6A:
undetectable
3u52C-5jm6A:
undetectable		 3u52A-5jm6A:
19.65
3u52C-5jm6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP A 306
GLU A 340
HIS A 485
GLU A 339
 ZN  A 601 ( 2.1A)
ZN  A 601 (-1.8A)
ZN  A 601 (-3.0A)
ZN  A 602 (-3.5A)
 1.06A 4hvrA-5jm6A:
undetectable		 4hvrA-5jm6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 332
MET A 470
LEU A 387
VAL A 477
 None
 1.21A 4okbA-5jm6A:
undetectable		 4okbA-5jm6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 132
ALA A 334
LEU A 387
PHE A 336
SER A 343
 None
 1.38A 4pb1A-5jm6A:
undetectable		 4pb1A-5jm6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 HIS A 133
ASP A 306
GLU A 339
GLU A 340
HIS A 485
 ZN  A 602 (-3.3A)
ZN  A 601 ( 2.1A)
ZN  A 602 (-3.5A)
ZN  A 601 (-1.8A)
ZN  A 601 (-3.0A)
 0.52A 4pqaA-5jm6A:
19.5		 4pqaA-5jm6A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 282
LEU A 194
VAL A 195
PHE A  69
 None
 1.04A 4uswA-5jm6A:
undetectable		 4uswA-5jm6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 333
SER A 432
LEU A 436
VAL A 477
LEU A 418
 None
 1.17A 5ubbA-5jm6A:
undetectable		 5ubbA-5jm6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASN A 447
VAL A 414
LEU A 494
GLN A 448
 None
 1.46A 5xdhA-5jm6A:
undetectable
5xdhC-5jm6A:
undetectable		 5xdhA-5jm6A:
13.25
5xdhC-5jm6A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 GLN A 448
ASN A 447
VAL A 414
LEU A 494
 None
 1.37A 5xdhA-5jm6A:
undetectable
5xdhC-5jm6A:
undetectable		 5xdhA-5jm6A:
13.25
5xdhC-5jm6A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5jm6 AMINOPEPTIDASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 TYR A 161
LEU A 282
GLY A 177
ASP A 338
VAL A  68
 None
 1.45A 6bxlA-5jm6A:
undetectable		 6bxlA-5jm6A:
22.18