SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 TRP A 399
ALA A 379
VAL A 381
 None
 0.85A 1c4dA-5jm7A:
undetectable
1c4dB-5jm7A:
undetectable		 1c4dA-5jm7A:
2.47
1c4dB-5jm7A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 LYS A 276
LEU A 290
ALA A 345
LEU A 343
 SO4  A 600 (-3.1A)
None
None
None
 1.10A 1eta2-5jm7A:
undetectable		 1eta2-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 6 MET A 274
LYS A 276
LEU A 290
LEU A 343
 None
SO4  A 600 (-3.1A)
None
None
 1.15A 1etb1-5jm7A:
undetectable		 1etb1-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 4 LYS A 276
LEU A 290
ALA A 345
LEU A 343
 SO4  A 600 (-3.1A)
None
None
None
 1.10A 1f86B-5jm7A:
undetectable		 1f86B-5jm7A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 7 PHE A 136
SER A 357
SER A 364
ALA A 139
 None
 1.13A 1fxvA-5jm7A:
undetectable
1fxvB-5jm7A:
undetectable		 1fxvA-5jm7A:
16.39
1fxvB-5jm7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 6 TRP A 126
ARG A 130
GLY A 372
ASP A 371
 None
 0.91A 1kf6M-5jm7A:
undetectable
1kf6N-5jm7A:
undetectable		 1kf6M-5jm7A:
21.61
1kf6N-5jm7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 ALA A 396
HIS A 397
VAL A 400
 None
 0.31A 1lqtB-5jm7A:
undetectable		 1lqtB-5jm7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 ALA A 396
HIS A 397
VAL A 400
 None
 0.33A 1lquB-5jm7A:
undetectable		 1lquB-5jm7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 6 LYS A 276
LEU A 290
ALA A 345
LEU A 343
 SO4  A 600 (-3.1A)
None
None
None
 1.06A 1tz8C-5jm7A:
undetectable
1tz8D-5jm7A:
undetectable		 1tz8C-5jm7A:
14.26
1tz8D-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 GLU A 504
THR A 493
LEU A 569
 None
 0.72A 1v8bC-5jm7A:
undetectable		 1v8bC-5jm7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 7 LEU A  83
LEU A  18
MET A 110
SER A 112
 None
 0.75A 1wrlE-5jm7A:
undetectable
1wrlF-5jm7A:
undetectable		 1wrlE-5jm7A:
10.20
1wrlF-5jm7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 LEU A 485
LEU A 411
MET A 518
 None
 0.79A 1ya3B-5jm7A:
undetectable		 1ya3B-5jm7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 PHE A 203
PHE A 344
PHE A 277
 None
 0.82A 2od9A-5jm7A:
undetectable		 2od9A-5jm7A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 9 LEU A  38
PHE A  63
GLN A  15
LEU A  21
ASN A  19
 None
 1.48A 2ok6B-5jm7A:
3.1
2ok6D-5jm7A:
undetectable		 2ok6B-5jm7A:
21.02
2ok6D-5jm7A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 10 LEU A  38
PHE A  63
GLN A  15
LEU A  21
ASN A  19
 None
 1.48A 2ok6A-5jm7A:
1.9
2ok6H-5jm7A:
undetectable		 2ok6A-5jm7A:
21.02
2ok6H-5jm7A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 PHE A 203
PHE A 344
PHE A 277
 None
 0.82A 2qqgA-5jm7A:
undetectable		 2qqgA-5jm7A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 12 PHE A  17
PHE A  50
PRO A 151
VAL A 109
LEU A  91
 None
 1.21A 2x2nC-5jm7A:
undetectable		 2x2nC-5jm7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 CYH A 102
HIS A 106
PHE A 105
 None
 0.94A 3cr4X-5jm7A:
undetectable		 3cr4X-5jm7A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_2
(RIBOFLAVIN UPTAKE
PROTEIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 4 TYR A 482
ASN A 534
ASN A 567
PHE A 490
 None
 1.16A 3p5nA-5jm7A:
0.0		 3p5nA-5jm7A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 12 LEU A 362
LEU A 365
LEU A 376
VAL A 381
ARG A 383
 None
 1.39A 3zqtA-5jm7A:
undetectable		 3zqtA-5jm7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 ILE A 275
ALA A 345
HIS A 225
ARG A 264
 None
None
None
SO4  A 600 (-4.2A)
 1.11A 4acaB-5jm7A:
undetectable
4acaC-5jm7A:
undetectable		 4acaB-5jm7A:
19.87
4acaC-5jm7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 LYS A 276
LEU A 290
ALA A 345
 SO4  A 600 (-3.1A)
None
None
 0.55A 4iizA-5jm7A:
undetectable		 4iizA-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 8 GLY A 440
ILE A 429
LEU A 411
LEU A 408
 None
 0.81A 4mwzB-5jm7A:
undetectable		 4mwzB-5jm7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 11 LEU A 129
ARG A 130
SER A 364
LEU A 365
LEU A 134
 None
 1.27A 4or0A-5jm7A:
undetectable		 4or0A-5jm7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 11 LEU A 129
ARG A 130
SER A 364
LEU A 365
LEU A 134
 None
 1.32A 4or0B-5jm7A:
4.0		 4or0B-5jm7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 GLN A 340
LEU A 343
SER A 342
ASP A 333
 None
 1.37A 4qtuD-5jm7A:
undetectable		 4qtuD-5jm7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 GLN A 393
HIS A 397
ARG A 510
 None
 1.15A 4qyqA-5jm7A:
undetectable		 4qyqA-5jm7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		3 / 3 GLN A 393
HIS A 397
ARG A 510
 None
 1.13A 4qyqB-5jm7A:
0.0		 4qyqB-5jm7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 9 VAL A 292
GLY A 330
ALA A 329
ILE A 275
VAL A 295
 None
 1.08A 4r21B-5jm7A:
undetectable		 4r21B-5jm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 ARG A 347
GLY A 327
GLU A 190
SER A 265
 SO4  A 600 (-2.7A)
None
None
SO4  A 600 (-3.0A)
 0.94A 4z3oA-5jm7A:
undetectable
4z3oB-5jm7A:
undetectable		 4z3oA-5jm7A:
22.10
4z3oB-5jm7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 6 ARG A 347
SER A 265
GLY A 327
GLU A 190
 SO4  A 600 (-2.7A)
SO4  A 600 (-3.0A)
None
None
 1.01A 5cdqA-5jm7A:
undetectable
5cdqC-5jm7A:
undetectable
5cdqD-5jm7A:
undetectable		 5cdqA-5jm7A:
21.70
5cdqC-5jm7A:
21.70
5cdqD-5jm7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		5 / 12 LEU A 507
LEU A 501
ALA A 396
ILE A 429
LEU A 408
 None
 1.01A 5h8tA-5jm7A:
undetectable		 5h8tA-5jm7A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 6 ARG A 202
PHE A 203
THR A 260
PHE A 136
 None
 1.40A 5mwyA-5jm7A:
undetectable		 5mwyA-5jm7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 4 VAL A  88
LEU A  91
LEU A  95
ASP A 557
 None
 1.47A 5xv7A-5jm7A:
5.2		 5xv7A-5jm7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 GLN A 358
THR A 359
THR A 261
LEU A 365
 None
 1.34A 6aphA-5jm7A:
undetectable		 6aphA-5jm7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 4 GLN A 358
THR A 359
THR A 261
LEU A 365
 None
 1.36A 6f3mA-5jm7A:
undetectable		 6f3mA-5jm7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 4 GLN A 358
THR A 359
THR A 261
LEU A 365
 None
 1.37A 6f3mC-5jm7A:
undetectable		 6f3mC-5jm7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5jm7 AEROBACTIN SYNTHASE
IUCA
(Klebsiella
pneumoniae) 		4 / 5 GLN A 358
THR A 359
THR A 261
LEU A 365
 None
 1.31A 6gbnB-5jm7A:
undetectable		 6gbnB-5jm7A:
20.99