SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Rattus
norvegicus) 		4 / 7 LYS B 533
THR B 511
THR B 493
VAL B 491
 None
 0.60A 1ictD-5jmcB:
undetectable		 1ictD-5jmcB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Rattus
norvegicus) 		4 / 5 PHE B 562
PHE B 517
PHE B 552
ILE B 483
 None
 1.25A 2v0mD-5jmcB:
undetectable		 2v0mD-5jmcB:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Rattus
norvegicus) 		4 / 8 ASP B 546
PHE B 507
LEU B 503
ASP B 524
 None
 0.97A 3m0wE-5jmcB:
undetectable
3m0wF-5jmcB:
undetectable
3m0wG-5jmcB:
undetectable
3m0wH-5jmcB:
undetectable		 3m0wE-5jmcB:
22.66
3m0wF-5jmcB:
22.66
3m0wG-5jmcB:
22.66
3m0wH-5jmcB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5jmc SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Rattus
norvegicus) 		4 / 8 PHE B 532
PHE B 522
SER B 515
TYR B 497
 None
 1.05A 6huoC-5jmcB:
undetectable
6huoD-5jmcB:
undetectable		 6huoC-5jmcB:
20.80
6huoD-5jmcB:
19.84