SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		5 / 12 GLU A 875
GLN A 867
TYR A 792
TYR A 720
TYR A 791
 None
 1.50A 1rkwA-5jnbA:
0.5		 1rkwA-5jnbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		5 / 12 SER A 595
ASN A 598
PHE A 600
ILE E 214
SER A 687
 SO4  A1001 ( 2.4A)
EDO  A1005 (-3.7A)
None
None
None
 1.26A 2o7oA-5jnbA:
undetectable		 2o7oA-5jnbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		5 / 10 ASP A 608
SER A 688
ILE E 214
PHE E 207
LEU A 590
 MG  A1002 (-3.1A)
None
None
None
None
 1.32A 2v0mA-5jnbA:
undetectable		 2v0mA-5jnbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		5 / 12 SER A 595
ASN A 598
PHE A 600
ILE E 214
SER A 687
 SO4  A1001 ( 2.4A)
EDO  A1005 (-3.7A)
None
None
None
 1.32A 2xpvA-5jnbA:
undetectable		 2xpvA-5jnbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		5 / 12 SER A 595
ASN A 598
PHE A 600
ILE E 214
SER A 687
 SO4  A1001 ( 2.4A)
EDO  A1005 (-3.7A)
None
None
None
 1.28A 2xpwA-5jnbA:
undetectable		 2xpwA-5jnbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 9 ILE A 677
PHE E 207
ARG E 206
PHE A 877
VAL A 723
 None
 1.28A 2ygpA-5jnbA:
undetectable		 2ygpA-5jnbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		4 / 7 TYR A 745
VAL A 726
ILE A 805
ARG A 694
 None
 1.11A 3ms9B-5jnbA:
undetectable		 3ms9B-5jnbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		3 / 3 THR E 218
SER E 217
ARG A 694
 None
 0.66A 3phnA-5jnbE:
undetectable		 3phnA-5jnbE:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		5 / 10 ILE E 193
ILE A 653
LEU A 628
THR A 614
ILE A 677
 None
 1.08A 3prsA-5jnbE:
undetectable		 3prsA-5jnbE:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		3 / 3 LEU A 781
MET A 546
ASP A 911
 None
 0.52A 3v5wA-5jnbA:
undetectable		 3v5wA-5jnbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING
(Caenorhabditis
elegans) 		4 / 6 ARG A 574
ALA E 204
ASP E 208
SER A 582
 None
 1.14A 4ot2A-5jnbA:
undetectable		 4ot2A-5jnbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		3 / 3 ARG A 692
ASP A 690
TRP A 691
 None
 1.05A 4xdqA-5jnbA:
undetectable		 4xdqA-5jnbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		3 / 3 ASN A 602
SER A 595
SER A 596
 SO4  A1001 (-3.5A)
SO4  A1001 ( 2.4A)
None
 0.55A 5gsnA-5jnbA:
undetectable		 5gsnA-5jnbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		4 / 5 PHE A 600
THR A 680
ASP A 608
ASN A 603
 None
EDO  A1005 (-3.8A)
MG  A1002 (-3.1A)
None
 1.44A 5ybbA-5jnbA:
undetectable		 5ybbA-5jnbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5jnb POLY(A) RNA
POLYMERASE GLD-2
(Caenorhabditis
elegans) 		3 / 3 ARG A 692
LEU A 784
PHE A 788
 None
 0.72A 6nknP-5jnbA:
undetectable		 6nknP-5jnbA:
21.99