SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 345
LEU A 338
LEU A 342
 None
 0.68A 1ikeA-5jneA:
undetectable		 1ikeA-5jneA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 514
ILE A 472
ASP A 520
LEU A 459
ILE A 457
 None
 0.84A 1yi4A-5jneA:
undetectable		 1yi4A-5jneA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 478
LEU A 459
SER A 462
ASP A 520
 None
 1.02A 3lm8A-5jneA:
3.3
3lm8C-5jneA:
3.2		 3lm8A-5jneA:
22.22
3lm8C-5jneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 520
LEU A 478
LEU A 459
SER A 462
 None
 1.04A 3lm8B-5jneA:
3.2
3lm8D-5jneA:
3.3		 3lm8B-5jneA:
22.22
3lm8D-5jneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 205
MET A 194
ASN A 195
 None
 0.78A 5qh8A-5jneA:
undetectable		 5qh8A-5jneA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 189
VAL A 311
LEU A 211
THR A 281
LEU A 284
 None
 1.21A 5tiwA-5jneA:
undetectable		 5tiwA-5jneA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 319
GLN A 392
ILE A 363
ASP A 384
ASP A 361
 None
 1.33A 6bxnA-5jneA:
undetectable		 6bxnA-5jneA:
22.50