SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 7 LEU C 336
ALA C 276
ILE C 321
LYS C 248
 None
 0.99A 1oniB-5jnfC:
undetectable
1oniC-5jnfC:
undetectable		 1oniB-5jnfC:
14.43
1oniC-5jnfC:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 9 TYR C  20
LEU C  24
VAL C 149
ILE C 148
PHE C 141
 None
 1.48A 1q6iA-5jnfC:
undetectable		 1q6iA-5jnfC:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 9 ASP C 265
LEU C 260
HIS C 324
LEU C 241
ILE C 320
 None
 1.37A 1sq5A-5jnfC:
undetectable		 1sq5A-5jnfC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 ASP C 265
LEU C 260
HIS C 324
LEU C 241
ILE C 320
 None
 1.41A 1sq5B-5jnfC:
undetectable		 1sq5B-5jnfC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 9 ASP C 265
LEU C 260
HIS C 324
LEU C 241
ILE C 320
 None
 1.39A 1sq5C-5jnfC:
undetectable		 1sq5C-5jnfC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 ASP C 265
LEU C 260
HIS C 324
LEU C 241
ILE C 320
 None
 1.38A 1sq5D-5jnfC:
undetectable		 1sq5D-5jnfC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 5 LEU C 388
GLY C 226
PRO C 416
VAL C 415
 None
 0.91A 2aojA-5jnfC:
undetectable		 2aojA-5jnfC:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU C 400
TYR C 439
ILE C 460
GLY C 482
 None
FMT  C 604 (-4.9A)
None
None
 0.93A 2du8A-5jnfC:
undetectable		 2du8A-5jnfC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU C 400
TYR C 439
ILE C 460
GLY C 482
 None
FMT  C 604 (-4.9A)
None
None
 0.90A 2du8B-5jnfC:
3.7		 2du8B-5jnfC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 9 TYR C 378
TYR C 478
GLY C 380
TYR C 375
HIS C 405
 None
 1.46A 2zm9A-5jnfC:
undetectable		 2zm9A-5jnfC:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 PHE C 448
GLY C 473
THR C 474
TYR C 475
ASN C 453
 None
 1.18A 3fw1A-5jnfC:
5.2		 3fw1A-5jnfC:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		3 / 3 ARG C 512
GLU C 536
ASP C 343
 None
 0.83A 3g2oA-5jnfC:
undetectable		 3g2oA-5jnfC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 11 ILE C 504
ILE C 515
GLU C 530
THR C 566
ILE C 533
 None
 0.93A 3kw4A-5jnfC:
undetectable		 3kw4A-5jnfC:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 TYR C  20
LEU C  24
VAL C 149
ILE C 148
PHE C 141
 None
 1.35A 3kz7A-5jnfC:
undetectable		 3kz7A-5jnfC:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 5 THR C 487
GLY C 539
ASN C 367
TYR C 347
 None
 1.22A 3u8qA-5jnfC:
undetectable		 3u8qA-5jnfC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 LEU C 271
VAL C 273
GLY C 277
ALA C 276
LEU C 336
 None
 1.14A 4coxC-5jnfC:
undetectable		 4coxC-5jnfC:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 ASN C 453
PHE C 456
VAL C 459
LEU C 426
 None
 1.17A 4f5zA-5jnfC:
undetectable		 4f5zA-5jnfC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 CYH C 486
ARG C 562
GLY C 539
TYR C 347
ARG C 510
 None
 1.47A 4kosA-5jnfC:
undetectable		 4kosA-5jnfC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 ARG C  68
GLY C  67
ASP C  46
HIS C  26
 None
 1.01A 4lajA-5jnfC:
undetectable
4lajB-5jnfC:
undetectable		 4lajA-5jnfC:
22.26
4lajB-5jnfC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 GLY C 582
ARG C 569
ASN C 479
THR C 491
LEU C 531
 None
 1.29A 5fhzD-5jnfC:
3.9		 5fhzD-5jnfC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		3 / 3 ARG C 457
THR C 382
ASP C 385
 None
 0.73A 5g5gA-5jnfC:
undetectable
5g5gB-5jnfC:
undetectable		 5g5gA-5jnfC:
18.01
5g5gB-5jnfC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 MET C 492
TYR C 478
LEU C 400
TYR C 375
PHE C 379
 None
 1.44A 5g6sB-5jnfC:
2.0
5g6sC-5jnfC:
2.8		 5g6sB-5jnfC:
21.53
5g6sC-5jnfC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 LEU C 407
LEU C 412
PHE C 205
LEU C 271
 None
 0.98A 5gs4A-5jnfC:
undetectable		 5gs4A-5jnfC:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 ILE C 100
LEU C  21
ILE C   4
TYR C  51
 None
 0.84A 5ieoA-5jnfC:
undetectable		 5ieoA-5jnfC:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 LEU C 264
HIS C 413
SER C 438
GLY C 409
LEU C 406
 None
 1.31A 5m50E-5jnfC:
undetectable		 5m50E-5jnfC:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 TYR C 481
ILE C 533
THR C 491
ILE C 508
 None
 0.96A 5mzrE-5jnfC:
undetectable		 5mzrE-5jnfC:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 8 THR C 404
LEU C 407
VAL C 213
TYR C 231
 None
 1.20A 5ov9B-5jnfC:
1.5		 5ov9B-5jnfC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 10 ALA C 242
LEU C 241
LEU C 305
VAL C 250
ILE C 303
 None
 1.05A 5v02B-5jnfC:
undetectable
5v02R-5jnfC:
undetectable		 5v02B-5jnfC:
9.73
5v02R-5jnfC:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		5 / 12 ASN C 175
GLU C 518
GLN C 523
PRO C 524
GLY C 526
 None
 1.45A 6gnfC-5jnfC:
2.9		 6gnfC-5jnfC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 ASP C 265
TYR C 329
ASP C 322
GLU C 311
 None
 1.31A 6mn5A-5jnfC:
undetectable		 6mn5A-5jnfC:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A
(Brevibacillus
parabrevis) 		4 / 6 ASP C 265
TYR C 329
ASP C 322
GLU C 311
 None
 1.29A 6mn5C-5jnfC:
undetectable		 6mn5C-5jnfC:
8.49