SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 ALA A 123
VAL A 115
TRP A 172
 None
 0.94A 1gmkC-5jnmA:
undetectable
1gmkD-5jnmA:
undetectable		 1gmkC-5jnmA:
3.09
1gmkD-5jnmA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2W_A_MTLA5600_0
(MANNITOL
DEHYDROGENASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		6 / 9 ASP A 150
LYS A 200
ASN A 205
HIS A 208
VAL A 281
LYS A 288
 None
None
SO4  A 401 (-4.6A)
None
None
SO4  A 401 ( 4.1A)
 0.64A 1m2wA-5jnmA:
28.9		 1m2wA-5jnmA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2W_B_MTLB6600_0
(MANNITOL
DEHYDROGENASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		6 / 9 ASP A 150
LYS A 200
ASN A 205
HIS A 208
VAL A 281
LYS A 288
 None
None
SO4  A 401 (-4.6A)
None
None
SO4  A 401 ( 4.1A)
 0.64A 1m2wB-5jnmA:
28.7		 1m2wB-5jnmA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 ALA A 209
LEU A 318
LYS A 321
ILE A 360
ILE A 289
 None
 1.27A 1rb3A-5jnmA:
undetectable		 1rb3A-5jnmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 LEU A  40
TYR A  46
ILE A  36
GLY A  14
 None
 0.83A 2du8A-5jnmA:
4.3		 2du8A-5jnmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 LEU A  40
TYR A  46
ILE A  36
GLY A  14
 None
 0.87A 2du8B-5jnmA:
4.4		 2du8B-5jnmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 ASN A 271
ASP A  52
ARG A  13
 None
 0.90A 3k13C-5jnmA:
undetectable		 3k13C-5jnmA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 ALA A  30
ASP A  31
ILE A  37
GLY A  12
ILE A  16
 None
 1.03A 3ogqB-5jnmA:
undetectable		 3ogqB-5jnmA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 ASN A 205
ALA A 209
TYR A 213
ASP A 276
 SO4  A 401 (-4.6A)
None
None
None
 1.17A 4mdaA-5jnmA:
undetectable		 4mdaA-5jnmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 8 ASP A 353
TYR A 303
ASP A 354
ILE A 296
 None
 0.97A 5cfsA-5jnmA:
undetectable		 5cfsA-5jnmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 ASN A 140
HIS A 143
LEU A 127
PHE A 101
ILE A 114
 None
 1.46A 5dv4A-5jnmA:
undetectable		 5dv4A-5jnmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A  17
GLY A  14
VAL A  27
THR A  28
ALA A  88
 None
 0.93A 5kpcB-5jnmA:
3.2		 5kpcB-5jnmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 LEU A 356
ILE A 289
LEU A 320
LEU A 367
ALA A 363
 None
 1.10A 5y7pG-5jnmA:
undetectable		 5y7pG-5jnmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 5 THR A 206
THR A 248
GLN A 258
ASP A 252
 None
 1.43A 6ectA-5jnmA:
3.7		 6ectA-5jnmA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 5 THR A 206
THR A 248
GLN A 258
ASP A 252
 None
 1.34A 6ecxA-5jnmA:
3.7		 6ecxA-5jnmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 8 VAL A 173
TYR A 196
TYR A 261
GLU A 167
 None
 1.15A 6gneB-5jnmA:
5.2		 6gneB-5jnmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 THR A 135
ILE A 134
ALA A  30
LEU A 105
LEU A  75
 None
 1.25A 6ie8A-5jnmA:
undetectable		 6ie8A-5jnmA:
18.58