SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		5 / 6 LYS A  61
LYS A  62
ASP A  65
ALA A  66
LEU A  84
 None
HEM  A 201 (-2.9A)
None
HEM  A 201 ( 3.8A)
HEM  A 201 (-4.6A)
 0.71A 1iwhA-5jnzA:
25.0		 1iwhA-5jnzA:
60.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5jnz BETA CHAIN
(Acipenser
stellatus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.2A)
None
HEM  B 201 (-4.1A)
HEM  B 201 (-3.4A)
 0.80A 1lh6A-5jnzB:
14.2		 1lh6A-5jnzB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.6A)
None
None
HEM  A 201 (-3.9A)
 1.00A 1wmqA-5jnzA:
undetectable		 1wmqA-5jnzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.6A)
None
None
HEM  A 201 (-3.9A)
 0.99A 1wmqB-5jnzA:
undetectable		 1wmqB-5jnzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.6A)
None
None
HEM  A 201 (-3.9A)
 0.98A 1wrqA-5jnzA:
undetectable		 1wrqA-5jnzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.6A)
None
None
HEM  A 201 (-3.9A)
 0.98A 1wrqB-5jnzA:
undetectable		 1wrqB-5jnzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		5 / 10 PHE A 129
LEU A 137
HIS A  88
ILE A  77
ALA A  66
 None
None
HEM  A 201 (-3.4A)
None
HEM  A 201 ( 3.8A)
 1.04A 2bxeB-5jnzA:
2.0		 2bxeB-5jnzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		5 / 12 SER A 103
ILE A 106
PHE A 129
ALA A 131
ALA A 138
 HEM  A 201 ( 4.9A)
None
None
None
None
 1.17A 2j0dA-5jnzA:
undetectable		 2j0dA-5jnzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 LEU A 110
LEU A 107
ILE A  24
ARG A  31
 None
 1.04A 2rlfA-5jnzA:
undetectable
2rlfB-5jnzA:
undetectable		 2rlfA-5jnzA:
17.97
2rlfB-5jnzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		4 / 6 SER A  53
ASP A  48
LYS A  62
GLU A  22
 None
None
HEM  A 201 (-2.9A)
None
 1.27A 2vn1B-5jnzA:
undetectable		 2vn1B-5jnzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5jnz BETA CHAIN
(Acipenser
stellatus) 		3 / 3 MET B 133
VAL B  12
GLU B   7
 None
 0.85A 3c6gA-5jnzB:
undetectable		 3c6gA-5jnzB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 5jnz ALPHA CHAIN
BETA CHAIN
(Acipenser
stellatus) 		5 / 12 GLU A  34
TYR A 113
GLU A  27
ARG A  31
TYR B 122
 None
 1.38A 3ckzA-5jnzA:
undetectable		 3ckzA-5jnzA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5jnz ALPHA CHAIN
(Acipenser
stellatus) 		5 / 9 LEU A 137
SER A  85
ILE A  77
ALA A  80
THR A  69
 None
 1.20A 3mdtA-5jnzA:
undetectable		 3mdtA-5jnzA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5jnz ALPHA CHAIN
BETA CHAIN
(Acipenser
stellatus;
Acipenser
stellatus) 		4 / 7 ILE B 112
VAL A 108
TYR B 122
GLN B 131
 None
None
None
GOL  B 202 ( 4.0A)
 1.27A 5kkzM-5jnzB:
undetectable
5kkzO-5jnzB:
undetectable		 5kkzM-5jnzB:
21.88
5kkzO-5jnzB:
18.98