SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jo7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 MET A 342
PRO A 339
ASP A 325
ARG A 329
 None
 1.25A 1dtlA-5jo7A:
undetectable		 1dtlA-5jo7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 GLU A 146
LEU A 183
GLY A 181
PHE A 178
ALA A 187
 None
 1.02A 1hvyA-5jo7A:
undetectable		 1hvyA-5jo7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 GLU A 146
LEU A 183
GLY A 181
PHE A 178
ALA A 187
 None
 1.07A 1hvyB-5jo7A:
undetectable		 1hvyB-5jo7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 GLU A 146
LEU A 183
GLY A 181
PHE A 178
ALA A 187
 None
 0.96A 1hvyD-5jo7A:
undetectable		 1hvyD-5jo7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 386
ASN A 404
TRP A 389
 None
 1.29A 1r15C-5jo7A:
undetectable		 1r15C-5jo7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 386
ASN A 404
TRP A 389
 None
 1.27A 1r15D-5jo7A:
undetectable		 1r15D-5jo7A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 10 LEU A 261
ALA A 298
ALA A 302
MET A 303
ASP A 355
 None
 1.25A 1rlbE-5jo7A:
undetectable		 1rlbE-5jo7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 10 LEU A 261
ALA A 298
ALA A 302
MET A 303
LEU A 349
 None
 1.25A 1rlbE-5jo7A:
undetectable		 1rlbE-5jo7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ILE A 439
ALA A 442
ASN A 518
ALA A 494
VAL A 508
 None
 0.95A 1xdkA-5jo7A:
undetectable		 1xdkA-5jo7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 TYR A 411
VAL A 284
GLY A 283
ILE A 301
 None
 0.65A 2a1mB-5jo7A:
undetectable		 2a1mB-5jo7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 TRP A 257
MET A 376
ALA A 348
LEU A 352
 None
 0.96A 2o01A-5jo7A:
undetectable		 2o01A-5jo7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ASN A 113
LEU A 156
LEU A 206
LEU A 121
THR A  68
 None
 1.17A 2oaxA-5jo7A:
undetectable		 2oaxA-5jo7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ASN A 113
LEU A 156
LEU A 206
LEU A 121
THR A  68
 None
 1.18A 2oaxB-5jo7A:
undetectable		 2oaxB-5jo7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ASN A 113
LEU A 156
LEU A 206
LEU A 121
THR A  68
 None
 1.22A 2oaxF-5jo7A:
undetectable		 2oaxF-5jo7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 LEU A 503
ASN A 499
ARG A 123
 None
 0.56A 2qhfA-5jo7A:
undetectable		 2qhfA-5jo7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 459
ASP A 452
TYR A 401
 None
 0.67A 2yvlB-5jo7A:
undetectable		 2yvlB-5jo7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 THR A  55
LEU A  59
ILE A  76
VAL A 117
LEU A 121
 None
 1.41A 3a51B-5jo7A:
0.8		 3a51B-5jo7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 LEU A 158
GLU A 174
ILE A 171
 None
 0.54A 3czhA-5jo7A:
undetectable		 3czhA-5jo7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ILE A 439
ALA A 442
ASN A 518
ALA A 494
VAL A 508
 None
 1.11A 3dzyA-5jo7A:
undetectable		 3dzyA-5jo7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 10 ILE A 439
ALA A 442
ALA A 494
VAL A 508
ILE A 512
 None
 0.98A 3falA-5jo7A:
undetectable		 3falA-5jo7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 THR A  55
LEU A  59
GLN A  89
HIS A  85
 None
 1.00A 3kp2A-5jo7A:
1.3
3kp2B-5jo7A:
1.2		 3kp2A-5jo7A:
15.74
3kp2B-5jo7A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 10 ILE A  90
ALA A  83
TYR A 222
LEU A 232
ILE A 553
 None
 1.14A 3prsA-5jo7A:
undetectable		 3prsA-5jo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 5 ARG A 448
LEU A 402
PRO A 396
ASP A 452
 None
 1.08A 3ufnA-5jo7A:
undetectable
3ufnB-5jo7A:
undetectable		 3ufnA-5jo7A:
11.44
3ufnB-5jo7A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 4 LEU A 297
ILE A 379
TYR A 353
TYR A 411
 None
 1.23A 3vt7A-5jo7A:
undetectable		 3vt7A-5jo7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 THR A 281
TYR A 419
ARG A 294
MET A 296
 None
 1.48A 3wipB-5jo7A:
undetectable
3wipC-5jo7A:
undetectable		 3wipB-5jo7A:
17.98
3wipC-5jo7A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 11 GLY A 463
GLU A 459
ASP A 452
TYR A 401
ARG A 448
 None
 1.02A 3wqwA-5jo7A:
undetectable		 3wqwA-5jo7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ILE A 133
GLU A  78
GLU A 160
HIS A 125
VAL A 129
 None
 1.28A 4a97B-5jo7A:
undetectable
4a97C-5jo7A:
undetectable		 4a97B-5jo7A:
19.92
4a97C-5jo7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 5 ILE A 523
ILE A 453
TYR A 527
GLU A 457
 None
 1.07A 4a99D-5jo7A:
undetectable		 4a99D-5jo7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 TYR A 290
ASP A 239
LEU A 246
GLU A 250
HIS A  85
 None
 1.44A 4b9zA-5jo7A:
undetectable		 4b9zA-5jo7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 ASP A 451
ARG A 273
THR A 455
 None
 0.80A 4i13A-5jo7A:
undetectable		 4i13A-5jo7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 ASP A 451
ARG A 273
THR A 455
 None
 0.79A 4p3rA-5jo7A:
undetectable		 4p3rA-5jo7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 511
THR A 426
HIS A 429
 None
 0.75A 4q15A-5jo7A:
undetectable		 4q15A-5jo7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 511
THR A 426
HIS A 429
 None
 0.74A 4q15B-5jo7A:
undetectable		 4q15B-5jo7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 GLU A 511
THR A 426
HIS A 429
 None
 0.77A 4ydqB-5jo7A:
undetectable		 4ydqB-5jo7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		5 / 12 ASP A 312
SER A 345
LEU A 349
ILE A 306
ARG A 271
 None
 1.48A 5uacC-5jo7A:
1.0		 5uacC-5jo7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		4 / 8 TYR A 285
THR A 417
TYR A 419
LEU A 519
 None
 1.45A 6cnjD-5jo7A:
2.4
6cnjE-5jo7A:
undetectable		 6cnjD-5jo7A:
10.32
6cnjE-5jo7A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5jo7 VETISPIRADIENE
SYNTHASE 1
(Hyoscyamus
muticus) 		3 / 3 ASP A 354
SER A 361
SER A 366
 None
 0.83A 6mxtA-5jo7A:
undetectable		 6mxtA-5jo7A:
21.25