SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		5 / 12 LEU A 190
GLY A  14
ASP A  38
ASP A  61
ASN A  88
 PO4  A 301 (-4.4A)
PO4  A 301 (-4.5A)
None
None
PO4  A 301 (-3.4A)
 1.05A 2bm9B-5jo9A:
6.2		 2bm9B-5jo9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		5 / 12 LEU A 190
GLY A  14
ASP A  38
ASN A  88
ALA A  89
 PO4  A 301 (-4.4A)
PO4  A 301 (-4.5A)
None
PO4  A 301 (-3.4A)
None
 0.87A 2bm9F-5jo9A:
5.8		 2bm9F-5jo9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 7 THR A  13
TYR A 153
ASN A 112
LEU A 190
 None
SOR  A 302 (-3.9A)
None
PO4  A 301 (-4.4A)
 1.19A 2hzqA-5jo9A:
undetectable		 2hzqA-5jo9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 7 PHE A 240
PRO A 195
LEU A 199
ALA A 202
 SOR  A 302 ( 4.7A)
None
None
None
 0.90A 2vcvA-5jo9A:
undetectable		 2vcvA-5jo9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		5 / 10 ALA A  87
VAL A 120
ILE A 135
GLY A 179
VAL A 116
 None
 0.88A 3t3cB-5jo9A:
undetectable		 3t3cB-5jo9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		5 / 12 GLY A  18
ALA A 211
ALA A 215
VAL A 214
ALA A  15
 PO4  A 301 (-3.4A)
None
None
None
None
 1.43A 4df3B-5jo9A:
8.9		 4df3B-5jo9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 8 LEU A  82
THR A  13
ALA A  11
VAL A  37
 None
 0.88A 4ik6B-5jo9A:
undetectable		 4ik6B-5jo9A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 6 GLY A 133
ASP A 134
ARG A 177
GLY A 175
 None
 0.95A 5cdnC-5jo9A:
undetectable
5cdnD-5jo9A:
3.1		 5cdnC-5jo9A:
19.96
5cdnD-5jo9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 6 GLY A 133
ASP A 134
ARG A 177
GLY A 175
 None
 0.95A 5cdnT-5jo9A:
undetectable
5cdnU-5jo9A:
3.0		 5cdnT-5jo9A:
19.96
5cdnU-5jo9A:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		12 / 12 TYR A  92
SER A 140
LEU A 141
THR A 147
TRP A 149
GLU A 150
GLY A 184
PRO A 185
VAL A 186
TRP A 194
PHE A 240
LEU A 242
 SOR  A 302 (-4.3A)
SOR  A 302 (-2.5A)
SOR  A 302 ( 3.8A)
SOR  A 302 (-3.8A)
SOR  A 302 ( 4.9A)
SOR  A 302 (-2.4A)
SOR  A 302 (-3.4A)
SOR  A 302 ( 2.8A)
SOR  A 302 ( 4.3A)
SOR  A 302 (-3.7A)
SOR  A 302 ( 4.7A)
SOR  A 302 ( 4.5A)
 0.12A 5jo9A-5jo9A:
45.7		 5jo9A-5jo9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		4 / 5 MET A 108
TYR A 153
GLY A  94
GLY A  95
 None
SOR  A 302 (-3.9A)
None
None
 1.06A 5x7pA-5jo9A:
undetectable		 5x7pA-5jo9A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5jo9 RIBITOL
2-DEHYDROGENASE
(Bradyrhizobium
japonicum) 		5 / 12 SER A  23
LEU A 222
VAL A 218
ILE A 181
ASP A 232
 None
 1.25A 6bxmA-5jo9A:
3.0		 6bxmA-5jo9A:
20.18