SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 4 SER A 278
ILE A 280
VAL A 246
THR A 219
 None
 1.24A 1u70A-5jodA:
undetectable		 1u70A-5jodA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 LEU A 124
TYR A 100
GLY A 127
ALA A  38
SER A  37
 None
 1.10A 2aylA-5jodA:
undetectable		 2aylA-5jodA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 GLU A  74
TRP A  41
PRO A  43
GLY A  84
 None
 1.14A 2hs1B-5jodA:
7.1		 2hs1B-5jodA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 SER A  61
ALA A  60
SER A  63
ASN A  25
 None
 1.07A 2i91A-5jodA:
undetectable		 2i91A-5jodA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 SER A  61
ALA A  60
SER A  63
ASN A  25
 None
 1.08A 2i91B-5jodA:
undetectable		 2i91B-5jodA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 ASP A  34
GLY A  36
SER A  37
TYR A  77
PHE A 120
 None
 0.88A 2v0zC-5jodA:
35.1		 2v0zC-5jodA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 10 VAL A 141
ALA A 152
PHE A 154
PHE A 156
LEU A 168
 None
 1.40A 3a3yA-5jodA:
undetectable		 3a3yA-5jodA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 4 ASP A  89
SER A  87
PHE A 102
SER A  92
 None
 1.45A 3i5uA-5jodA:
undetectable		 3i5uA-5jodA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 PHE A  31
LEU A  40
PHE A 102
TYR A  58
ILE A  22
 None
 1.42A 3o94A-5jodA:
undetectable		 3o94A-5jodA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 PHE A  31
LEU A  40
PHE A 102
TYR A  58
ILE A  22
 None
 1.43A 3o94C-5jodA:
undetectable		 3o94C-5jodA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 PHE A  31
LEU A  40
PHE A 102
TYR A  58
ILE A  22
 None
 1.41A 3o94D-5jodA:
undetectable		 3o94D-5jodA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 6 SER A  37
ILE A  75
TYR A  77
ASP A 121
 None
 1.03A 3q70A-5jodA:
10.1		 3q70A-5jodA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 ALA A 222
PHE A 231
PHE A 230
MET A 274
LEU A 254
 None
 1.23A 4eckA-5jodA:
undetectable		 4eckA-5jodA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 HIS A 161
ALA A 325
ILE A  86
GLY A 166
GLY A  83
 None
 1.17A 4hfpB-5jodA:
undetectable		 4hfpB-5jodA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 6 TRP A 193
ILE A 195
VAL A 312
SER A 261
 None
 0.95A 4iaqA-5jodA:
undetectable		 4iaqA-5jodA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 8 ASN A 188
ASP A 214
ASN A 210
ILE A 294
 None
 1.06A 4k0bA-5jodA:
undetectable		 4k0bA-5jodA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 8 ASN A 188
ASP A 214
ASN A 210
ILE A 294
 None
 1.02A 4l7iA-5jodA:
undetectable		 4l7iA-5jodA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 GLY A 171
GLY A 172
ALA A 152
LEU A 153
GLU A 316
 GOL  A 406 ( 4.3A)
None
None
None
None
 1.18A 4l8fB-5jodA:
undetectable		 4l8fB-5jodA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 GLY A 171
GLY A 172
ALA A 152
LEU A 153
GLU A 316
 GOL  A 406 ( 4.3A)
None
None
None
None
 1.18A 4l8fD-5jodA:
undetectable		 4l8fD-5jodA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 5 ILE A  86
PHE A 310
SER A 218
HIS A  90
 None
 1.09A 4rzvB-5jodA:
undetectable		 4rzvB-5jodA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 4 LEU A  40
ILE A 103
GLY A 125
ILE A  75
 None
 0.82A 5dzk3-5jodA:
undetectable
5dzkm-5jodA:
undetectable		 5dzk3-5jodA:
0.53
5dzkm-5jodA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 5 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.82A 5dzkB-5jodA:
undetectable
5dzkI-5jodA:
undetectable
5dzkW-5jodA:
undetectable		 5dzkB-5jodA:
19.20
5dzkI-5jodA:
20.11
5dzkW-5jodA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 5 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.82A 5dzki-5jodA:
undetectable
5dzkj-5jodA:
undetectable
5dzkx-5jodA:
undetectable		 5dzki-5jodA:
20.11
5dzkj-5jodA:
20.11
5dzkx-5jodA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 9 LEU A 244
VAL A 246
VAL A 239
ILE A 280
ASP A 281
 None
 1.20A 5yf9X-5jodA:
undetectable		 5yf9X-5jodA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 VAL A 320
PRO A 159
PHE A 177
LEU A 158
 None
 1.19A 6aycA-5jodA:
undetectable		 6aycA-5jodA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 8 ASP A 162
HIS A  90
HIS A 161
ASP A 303
 GOL  A 402 (-2.9A)
None
None
None
 1.21A 6mn4C-5jodA:
undetectable		 6mn4C-5jodA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 8 HIS A  90
ARG A 307
HIS A 161
ASP A 303
 None
 1.21A 6mn4D-5jodA:
undetectable		 6mn4D-5jodA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jod PROPLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 HIS A  90
ARG A 307
HIS A 161
ASP A 303
 None
 1.36A 6mn4F-5jodA:
undetectable		 6mn4F-5jodA:
19.73