SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 6 VAL A-361
VAL A-319
ILE A-309
ASN A-102
 None
 0.89A 1e06A-5jonA:
undetectable		 1e06A-5jonA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		3 / 3 GLU A-258
TRP A-139
LYS A -96
 MAL  A 701 (-2.9A)
MAL  A 701 ( 4.5A)
None
 1.24A 1qu2A-5jonA:
undetectable		 1qu2A-5jonA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 12 ILE A 545
ALA A 593
ILE A 557
ILE A 544
THR A 592
 None
None
None
None
NO3  A 702 (-4.5A)
 1.12A 1re7A-5jonA:
undetectable		 1re7A-5jonA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 7 GLY A 581
SER A 605
ARG A 591
GLU A 536
 NO3  A 702 (-3.3A)
None
NO3  A 702 (-4.2A)
None
 0.99A 2c8aB-5jonA:
undetectable		 2c8aB-5jonA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A-276
GLN A -44
ALA A -45
ALA A -66
ALA A -68
 None
 1.16A 2f16H-5jonA:
undetectable
2f16I-5jonA:
undetectable		 2f16H-5jonA:
19.84
2f16I-5jonA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A-276
GLN A -44
ALA A -45
ALA A -66
ALA A -68
 None
 1.15A 2f16V-5jonA:
undetectable
2f16W-5jonA:
undetectable		 2f16V-5jonA:
19.84
2f16W-5jonA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		3 / 3 LYS A 532
GLY A-313
PRO A-312
 None
 0.87A 2hreB-5jonA:
undetectable		 2hreB-5jonA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 6 ALA A-181
LEU A-177
ALA A -23
THR A -24
 None
 0.89A 3b6hA-5jonA:
undetectable		 3b6hA-5jonA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 6 ALA A-181
LEU A-177
ALA A -23
THR A -24
 None
 0.91A 3b6hB-5jonA:
undetectable		 3b6hB-5jonA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 6 PHE A-111
ALA A-207
LEU A-122
PRO A-210
 None
 0.94A 3bgdA-5jonA:
undetectable		 3bgdA-5jonA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 7 VAL A-259
GLY A -69
PRO A-140
LYS A -64
 None
 0.67A 3bjwC-5jonA:
undetectable		 3bjwC-5jonA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 8 VAL A-259
GLY A -69
PRO A-140
LYS A -64
 None
 0.89A 3bjwA-5jonA:
undetectable		 3bjwA-5jonA:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		9 / 12 ASP A-355
LYS A-354
GLU A-325
GLU A-324
ALA A-306
ASP A-304
ARG A-303
GLU A-258
TRP A-139
 MAL  A 701 (-2.7A)
MAL  A 701 (-2.8A)
None
None
MAL  A 701 (-3.3A)
MAL  A 701 (-2.8A)
MAL  A 701 (-3.8A)
MAL  A 701 (-2.9A)
MAL  A 701 ( 4.5A)
 0.78A 3jyrA-5jonA:
62.0		 3jyrA-5jonA:
65.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		9 / 12 ASP A-355
LYS A-354
GLU A-325
GLU A-324
ALA A-306
ASP A-304
GLU A-258
PRO A-215
TRP A-139
 MAL  A 701 (-2.7A)
MAL  A 701 (-2.8A)
None
None
MAL  A 701 (-3.3A)
MAL  A 701 (-2.8A)
MAL  A 701 (-2.9A)
MAL  A 701 (-3.4A)
MAL  A 701 ( 4.5A)
 0.49A 3jyrA-5jonA:
62.0		 3jyrA-5jonA:
65.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		6 / 7 ASN A-357
TRP A-307
GLU A-216
TYR A-214
MET A -39
TRP A -29
 MAL  A 701 (-4.5A)
MAL  A 701 (-4.3A)
MAL  A 701 (-3.6A)
MAL  A 701 (-3.9A)
MAL  A 701 ( 4.3A)
MAL  A 701 (-3.7A)
 0.25A 3jyrA-5jonA:
62.0		 3jyrA-5jonA:
65.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A-173
LEU A-209
GLY A-182
ALA A-181
LEU A  -8
 None
 1.00A 3n8yB-5jonA:
undetectable		 3n8yB-5jonA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A-213
GLY A -69
LEU A -70
GLU A-258
ALA A-138
 MAL  A 701 ( 4.9A)
None
None
MAL  A 701 (-2.9A)
None
 0.86A 3tbgB-5jonA:
undetectable		 3tbgB-5jonA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A-213
GLY A -69
LEU A -70
GLU A-258
ALA A-138
 MAL  A 701 ( 4.9A)
None
None
MAL  A 701 (-2.9A)
None
 0.84A 3tbgD-5jonA:
undetectable		 3tbgD-5jonA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 6 GLU A -61
ASP A -55
ASP A -82
ASN A -75
 None
 1.33A 3vywA-5jonA:
undetectable		 3vywA-5jonA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 5 GLU A -61
ASP A -55
ASP A -82
ASN A -75
 None
 1.31A 3vywD-5jonA:
undetectable		 3vywD-5jonA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 9 ALA A-105
ALA A-264
LEU A-266
LEU A-107
VAL A-108
 None
 1.14A 4or0B-5jonA:
undetectable		 4or0B-5jonA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 12 GLY A-350
GLU A-347
ALA A -77
TYR A -62
SER A-136
 None
 1.35A 4pb1A-5jonA:
undetectable		 4pb1A-5jonA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		4 / 4 VAL A-259
ALA A-257
ILE A -52
THR A -49
 None
 1.18A 5e4dB-5jonA:
undetectable		 5e4dB-5jonA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		6 / 12 ALA A -27
ALA A -31
GLY A-203
ALA A-181
PHE A-200
VAL A-188
 None
 1.41A 5w4zA-5jonA:
undetectable		 5w4zA-5jonA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		6 / 12 ALA A -27
ALA A -31
GLY A-203
ALA A-181
PHE A-200
VAL A-188
 None
 1.44A 5w4zB-5jonA:
undetectable		 5w4zB-5jonA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		3 / 3 TYR A-214
ASN A-142
LEU A-256
 MAL  A 701 (-3.9A)
None
None
 0.83A 6b58A-5jonA:
undetectable		 6b58A-5jonA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2
(Escherichia
coli;
Mus
musculus) 		5 / 11 PRO A-236
GLU A-239
PRO A-115
ALA A-206
PRO A-210
 None
 1.45A 6bm5A-5jonA:
undetectable		 6bm5A-5jonA:
21.84