SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		3 / 4 LYS A  99
ALA A 100
MET A  75
 None
 1.02A 1hk3A-5josA:
undetectable		 1hk3A-5josA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 12 GLY A  28
GLY A  88
ILE A  19
PRO A 214
VAL A  90
 None
 0.99A 2hmyB-5josA:
undetectable		 2hmyB-5josA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		4 / 6 ARG A 149
PHE A 147
ILE A 179
PHE A 204
 None
 1.19A 2qeiA-5josA:
undetectable		 2qeiA-5josA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 11 VAL A 224
LEU A  16
SER A  59
ILE A  19
ALA A  86
 None
 1.00A 2zbzA-5josA:
undetectable		 2zbzA-5josA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 9 VAL A 224
LEU A  16
SER A  59
ILE A  19
GLY A 210
 None
 1.11A 3cv9A-5josA:
undetectable		 3cv9A-5josA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		4 / 8 ASP A 128
ILE A 129
VAL A 177
VAL A 115
 None
 0.71A 3fi0G-5josA:
undetectable		 3fi0G-5josA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		4 / 8 ASP A 128
ILE A 129
VAL A 177
VAL A 115
 None
 0.75A 3fi0Q-5josA:
undetectable		 3fi0Q-5josA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		4 / 8 TYR A 106
TYR A  33
LEU A  74
TRP A  71
 None
 1.41A 3uzzB-5josA:
undetectable		 3uzzB-5josA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 9 ASP A  51
ILE A  50
THR A  29
GLY A  28
ARG A  22
 None
 1.15A 4acaB-5josA:
undetectable
4acaC-5josA:
undetectable		 4acaB-5josA:
18.54
4acaC-5josA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 10 GLY A  28
THR A  69
PHE A 220
LEU A  78
LEU A  74
 None
 1.33A 5fhzC-5josA:
undetectable		 5fhzC-5josA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5jos CYCLOHEXADIENYL
DEHYDRATASE
(synthetic
construct) 		5 / 12 GLU A  95
THR A  91
ARG A  96
THR A  30
GLY A  88
 None
 1.20A 5xipA-5josA:
2.3		 5xipA-5josA:
18.44