SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 8 PHE A  44
PHE A  62
ARG A  95
ALA A  41
 None
 0.95A 1rqpC-5jp5A:
undetectable		 1rqpC-5jp5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 8 PHE A  44
PHE A  62
ARG A  95
ALA A  41
 None
 0.98A 1rqpA-5jp5A:
undetectable		 1rqpA-5jp5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		5 / 12 HIS A 115
LEU A  84
GLY A  86
VAL A  67
ALA A  66
 None
 1.15A 2kceB-5jp5A:
undetectable		 2kceB-5jp5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 8 PRO A  85
SER A  83
GLU A 118
ARG A  69
 None
 0.96A 2v32C-5jp5A:
undetectable
2v32D-5jp5A:
undetectable		 2v32C-5jp5A:
22.22
2v32D-5jp5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 8 PRO A  85
SER A  83
GLU A 118
ARG A  69
 None
 0.88A 2v41C-5jp5A:
undetectable
2v41D-5jp5A:
undetectable		 2v41C-5jp5A:
22.22
2v41D-5jp5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 8 PRO A  85
SER A  83
GLU A 118
ARG A  69
 None
 1.00A 2v41C-5jp5A:
undetectable
2v41D-5jp5A:
undetectable		 2v41C-5jp5A:
22.22
2v41D-5jp5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		5 / 11 ALA A  55
ASP A  53
ILE A  46
ILE A  21
ILE A 129
 None
 0.99A 3ebzA-5jp5A:
undetectable		 3ebzA-5jp5A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		6 / 6 HIS A  57
ASN A  59
ARG A  61
ASN A  70
TRP A  77
GLU A  80
 PEG  A 201 (-3.7A)
PEG  A 201 ( 4.8A)
PEG  A 201 (-3.0A)
PEG  A 201 (-3.6A)
PEG  A 201 (-2.8A)
PEG  A 201 (-3.3A)
 0.41A 3galA-5jp5A:
23.0		 3galA-5jp5A:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		6 / 6 HIS A  57
ASN A  59
ARG A  61
ASN A  70
TRP A  77
GLU A  80
 PEG  A 201 (-3.7A)
PEG  A 201 ( 4.8A)
PEG  A 201 (-3.0A)
PEG  A 201 (-3.6A)
PEG  A 201 (-2.8A)
PEG  A 201 (-3.3A)
 0.36A 3galB-5jp5A:
23.0		 3galB-5jp5A:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		5 / 12 PRO A 127
GLY A  24
LEU A 123
ILE A  54
GLY A  51
 None
 0.93A 4n48A-5jp5A:
undetectable		 4n48A-5jp5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 7 LEU A 140
THR A 145
THR A  19
LEU A 132
 None
 0.85A 4z91F-5jp5A:
undetectable
4z91G-5jp5A:
undetectable
4z91H-5jp5A:
undetectable
4z91I-5jp5A:
undetectable
4z91J-5jp5A:
undetectable		 4z91F-5jp5A:
19.31
4z91G-5jp5A:
19.31
4z91H-5jp5A:
19.31
4z91I-5jp5A:
19.31
4z91J-5jp5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		7 / 7 HIS A  57
ASN A  59
ARG A  61
ASN A  70
TRP A  77
GLU A  80
ARG A  82
 PEG  A 201 (-3.7A)
PEG  A 201 ( 4.8A)
PEG  A 201 (-3.0A)
PEG  A 201 (-3.6A)
PEG  A 201 (-2.8A)
PEG  A 201 (-3.3A)
None
 0.28A 6b8kA-5jp5A:
24.4		 6b8kA-5jp5A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		7 / 8 HIS A  57
ASN A  59
ARG A  61
ASN A  70
TRP A  77
GLU A  80
ARG A  82
 PEG  A 201 (-3.7A)
PEG  A 201 ( 4.8A)
PEG  A 201 (-3.0A)
PEG  A 201 (-3.6A)
PEG  A 201 (-2.8A)
PEG  A 201 (-3.3A)
None
 0.52A 6b94A-5jp5A:
19.3		 6b94A-5jp5A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		7 / 10 HIS A  57
ASN A  59
ARG A  61
ASN A  70
TRP A  77
GLU A  80
ARG A  82
 PEG  A 201 (-3.7A)
PEG  A 201 ( 4.8A)
PEG  A 201 (-3.0A)
PEG  A 201 (-3.6A)
PEG  A 201 (-2.8A)
PEG  A 201 (-3.3A)
None
 0.45A 6b94A-5jp5A:
19.3
6b94B-5jp5A:
18.7		 6b94A-5jp5A:
25.56
6b94B-5jp5A:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 4 ARG A  61
GLU A  64
GLU A  80
ARG A  82
 PEG  A 201 (-3.0A)
None
PEG  A 201 (-3.3A)
None
 0.50A 6fk2A-5jp5A:
24.6		 6fk2A-5jp5A:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 5jp5 GALECTIN-5
(Rattus
norvegicus) 		4 / 4 ARG A  82
GLU A  80
GLU A  64
ARG A  61
 None
PEG  A 201 (-3.3A)
None
PEG  A 201 (-3.0A)
 1.04A 6fk2A-5jp5A:
24.6		 6fk2A-5jp5A:
41.13