SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ASP A 302
ASP A 274
 None
 0.73A 1eizA-5jp9A:
undetectable		 1eizA-5jp9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ASP A 302
ASP A 274
 None
 0.74A 1ej0A-5jp9A:
undetectable		 1ej0A-5jp9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 7 TYR A  72
HIS A 295
TYR A  85
TRP A 324
 None
 1.30A 1mxgA-5jp9A:
undetectable		 1mxgA-5jp9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 4 VAL A 122
ALA A 135
LEU A 168
PHE A 161
 None
 1.20A 1q97B-5jp9A:
undetectable		 1q97B-5jp9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 VAL A 254
SER A 189
PHE A 190
ILE A  82
PHE A  64
 None
 1.44A 1skxA-5jp9A:
undetectable		 1skxA-5jp9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 7 ARG A 256
LEU A 279
PRO A 243
MET A 245
 None
 1.36A 2hrcA-5jp9A:
undetectable		 2hrcA-5jp9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ILE A  53
LEU A  45
PHE A  43
GLN A  16
ALA A 179
 None
 1.29A 2jj8C-5jp9A:
undetectable		 2jj8C-5jp9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 5 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.44A 2yqzA-5jp9A:
undetectable		 2yqzA-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 5 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.43A 2yqzB-5jp9A:
undetectable		 2yqzB-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.15A 3k2hA-5jp9A:
22.9		 3k2hA-5jp9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.16A 3k2hB-5jp9A:
23.2		 3k2hB-5jp9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 HIS A 253
PHE A  66
PHE A 192
 None
 0.74A 3lk0D-5jp9A:
undetectable		 3lk0D-5jp9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.23A 3nrrB-5jp9A:
undetectable		 3nrrB-5jp9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 GLY A 172
ARG A  58
GLY A  42
ALA A 183
ALA A 179
 None
 1.11A 3sueB-5jp9A:
undetectable		 3sueB-5jp9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 SER A 189
PHE A 188
LEU A 258
VAL A 257
PHE A 292
 None
 1.41A 3u9fJ-5jp9A:
undetectable
3u9fL-5jp9A:
undetectable		 3u9fJ-5jp9A:
20.49
3u9fL-5jp9A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 PHE A  64
SER A 189
SER A 185
 None
 0.99A 3ufgB-5jp9A:
undetectable		 3ufgB-5jp9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 5 ILE A 205
TRP A 285
TRP A 251
TRP A 119
 None
 1.40A 3wemA-5jp9A:
0.0		 3wemA-5jp9A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ARG A 306
ASP A 274
 None
 0.83A 4fp9D-5jp9A:
undetectable		 4fp9D-5jp9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ARG A 306
ASP A 274
 None
 0.82A 4fzvA-5jp9A:
undetectable		 4fzvA-5jp9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 GLU A 195
ARG A 199
GLN A  50
 None
 0.82A 4rtbA-5jp9A:
undetectable		 4rtbA-5jp9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 LEU A 159
GLY A 172
SER A 185
PHE A 192
GLU A  68
 None
 1.12A 5czyA-5jp9A:
undetectable		 5czyA-5jp9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ARG A 306
ASP A 274
 None
 0.84A 5zvgA-5jp9A:
undetectable		 5zvgA-5jp9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		3 / 3 ASP A 305
ARG A 306
ASP A 274
 None
 0.85A 5zvgB-5jp9A:
undetectable		 5zvgB-5jp9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 VAL A 288
THR A 191
VAL A 187
VAL A  62
ASN A  65
 None
 1.42A 6h7lA-5jp9A:
undetectable		 6h7lA-5jp9A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 VAL A 288
THR A 191
VAL A 187
VAL A  62
ASN A  65
 None
 1.42A 6h7lB-5jp9A:
undetectable		 6h7lB-5jp9A:
18.07