SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		3 / 3 ASP A 257
HIS A 290
HIS A 231
 FLC  A 501 (-3.8A)
FLC  A 501 (-3.8A)
FLC  A 501 (-3.9A)
 0.67A 1oe1A-5jpeA:
undetectable		 1oe1A-5jpeA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		3 / 3 ASP A 257
HIS A 290
HIS A 231
 FLC  A 501 (-3.8A)
FLC  A 501 (-3.8A)
FLC  A 501 (-3.9A)
 0.66A 1oe3A-5jpeA:
undetectable		 1oe3A-5jpeA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 7 LEU A 255
GLY A 256
LEU A 253
PRO A 325
 None
 0.92A 1ya4B-5jpeA:
undetectable		 1ya4B-5jpeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		5 / 5 LEU A 366
ILE A 326
LEU A 217
SER A 216
ARG A 352
 None
 1.35A 2byoA-5jpeA:
undetectable		 2byoA-5jpeA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 5 VAL A 429
THR A 430
VAL A 416
GLY A 419
 None
 1.10A 2p2fA-5jpeA:
undetectable		 2p2fA-5jpeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 4 VAL A 429
THR A 430
VAL A 416
GLY A 419
 None
 1.08A 2p2fB-5jpeA:
undetectable		 2p2fB-5jpeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 6 ARG A 208
PHE A 321
ILE A 269
PHE A 301
 None
 1.26A 2qeiA-5jpeA:
undetectable		 2qeiA-5jpeA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		3 / 3 ASP A 257
HIS A 290
HIS A 231
 FLC  A 501 (-3.8A)
FLC  A 501 (-3.8A)
FLC  A 501 (-3.9A)
 0.70A 2xxgA-5jpeA:
undetectable		 2xxgA-5jpeA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		3 / 3 ASP A 257
HIS A 290
HIS A 231
 FLC  A 501 (-3.8A)
FLC  A 501 (-3.8A)
FLC  A 501 (-3.9A)
 0.71A 2xxgC-5jpeA:
undetectable		 2xxgC-5jpeA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		5 / 12 GLY A 256
ILE A 240
LEU A 237
LEU A 271
ILE A 269
 None
 1.23A 3adsB-5jpeA:
undetectable		 3adsB-5jpeA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 7 GLY A 339
GLY A 228
PHE A 406
PHE A 400
 None
 0.86A 3ko0M-5jpeA:
undetectable
3ko0P-5jpeA:
undetectable		 3ko0M-5jpeA:
18.95
3ko0P-5jpeA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 6 PHE A 283
TYR A 275
VAL A 230
PHE A 241
 None
 1.25A 3ltwA-5jpeA:
undetectable		 3ltwA-5jpeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 6 PHE A 283
VAL A 230
THR A 268
PHE A 241
 None
 1.37A 3ltwA-5jpeA:
undetectable		 3ltwA-5jpeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 7 TYR A 234
LEU A 181
ASP A 178
TYR A 275
 None
 0.87A 3rodD-5jpeA:
undetectable		 3rodD-5jpeA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		5 / 12 ASP A 229
LEU A 428
ASN A 289
THR A 430
GLY A 288
 FLC  A 501 (-3.1A)
None
FLC  A 501 (-3.1A)
None
None
 1.10A 3uq6B-5jpeA:
undetectable		 3uq6B-5jpeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		3 / 3 LYS A 276
ARG A 356
LEU A 218
 None
 1.34A 3v4tE-5jpeA:
undetectable		 3v4tE-5jpeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		5 / 12 ASP A 229
LEU A 428
ASN A 289
THR A 430
GLY A 288
 FLC  A 501 (-3.1A)
None
FLC  A 501 (-3.1A)
None
None
 1.12A 3vaqB-5jpeA:
undetectable		 3vaqB-5jpeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		5 / 11 CYH A 456
CYH A 336
ALA A 331
VAL A 226
LEU A 253
 None
 1.15A 4p65C-5jpeA:
undetectable
4p65D-5jpeA:
undetectable
4p65J-5jpeA:
undetectable
4p65L-5jpeA:
undetectable		 4p65C-5jpeA:
6.16
4p65D-5jpeA:
7.75
4p65J-5jpeA:
7.75
4p65L-5jpeA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Candida
albicans) 		4 / 4 ASP A 257
HIS A 338
HIS A 413
HIS A 290
 FLC  A 501 (-3.8A)
None
FLC  A 501 (-4.0A)
FLC  A 501 (-3.8A)
 1.43A 5ncdD-5jpeA:
undetectable		 5ncdD-5jpeA:
21.36