SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 TYR C1701
ASP C1689
GLU C1624
PHE C1627
 None
 1.29A 1b2iA-5jpnC:
undetectable		 1b2iA-5jpnC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR C1559
VAL B1306
ILE B1307
TYR B1267
LEU B1078
 None
 1.00A 1fm4A-5jpnC:
undetectable		 1fm4A-5jpnC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 GLN A 430
LEU A 558
ARG A 559
LEU A 489
 None
 1.08A 1hk3A-5jpnA:
undetectable		 1hk3A-5jpnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 TRP B1230
TYR B1229
LEU B1289
 None
 1.06A 1kxhA-5jpnB:
undetectable		 1kxhA-5jpnB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 SER A  27
GLY A 129
LEU A  58
ILE A 130
LEU A 132
 None
 1.32A 1lhuA-5jpnA:
undetectable		 1lhuA-5jpnA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 TYR C1625
LEU C1675
PHE C1643
VAL C1669
VAL C1629
 None
 1.12A 1q23H-5jpnC:
undetectable
1q23I-5jpnC:
undetectable		 1q23H-5jpnC:
20.27
1q23I-5jpnC:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 GLY C1537
HIS C1467
LEU C1579
VAL C1549
LEU C1490
 None
 1.19A 1r30B-5jpnC:
undetectable		 1r30B-5jpnC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B1213
LEU B1200
ALA B1143
VAL B1139
ALA B1192
 None
 1.06A 1sa1A-5jpnB:
undetectable
1sa1B-5jpnB:
undetectable		 1sa1A-5jpnB:
20.00
1sa1B-5jpnB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B1213
LEU B1200
ALA B1143
VAL B1139
ALA B1192
 None
 1.06A 1sa1C-5jpnB:
undetectable
1sa1D-5jpnB:
undetectable		 1sa1C-5jpnB:
20.00
1sa1D-5jpnB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 LEU A  91
HIS A 100
LYS A  95
 None
 0.80A 1y7iA-5jpnA:
undetectable		 1y7iA-5jpnA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ARG B1026
GLY B 990
GLY B 998
GLY B 999
VAL B1000
 None
 0.88A 2avsA-5jpnB:
undetectable		 2avsA-5jpnB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 LYS B1390
ASP B 973
ASP B 965
 NAG  B1509 ( 4.7A)
None
None
 0.81A 2br4D-5jpnB:
undetectable		 2br4D-5jpnB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 6 ARG C1498
THR C1517
VAL C1522
LEU C1490
 None
 1.07A 2e1qC-5jpnC:
undetectable		 2e1qC-5jpnC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 TYR B1066
GLY B1064
THR B1103
ASP B1063
 None
 1.08A 2g70A-5jpnB:
undetectable		 2g70A-5jpnB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.14A 2igtA-5jpnB:
undetectable		 2igtA-5jpnB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.13A 2igtB-5jpnB:
undetectable		 2igtB-5jpnB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ALA B 915
SER B 866
ALA B 884
ALA B 926
GLY B 924
 None
 1.15A 2igtC-5jpnB:
undetectable		 2igtC-5jpnB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 LEU A 264
PHE A 284
ILE A 312
GLU A 318
 None
 0.88A 2opxA-5jpnA:
undetectable		 2opxA-5jpnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 VAL B 854
VAL B 927
ASP B 925
VAL B 913
 None
 0.92A 2qbnA-5jpnB:
undetectable		 2qbnA-5jpnB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 PRO A 478
ASN A 492
ARG A 494
 None
 0.86A 2qeuB-5jpnA:
undetectable		 2qeuB-5jpnA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 ALA C1484
TYR C1559
ALA C1486
TYR C1525
 None
 1.27A 2wlkA-5jpnC:
3.3
2wlkB-5jpnC:
3.2		 2wlkA-5jpnC:
21.05
2wlkB-5jpnC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 ARG B 831
GLY B 924
GLU B 832
SER B 928
 None
 1.27A 2xctS-5jpnB:
undetectable
2xctU-5jpnB:
undetectable		 2xctS-5jpnB:
22.02
2xctU-5jpnB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 10 GLY B 998
VAL B1000
ALA B1001
THR B1021
ARG A 187
 None
 1.27A 3a3yA-5jpnB:
undetectable		 3a3yA-5jpnB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 11 LEU A 386
VAL A 431
SER A 432
ALA A 450
ALA A 458
 None
 1.13A 3mdtB-5jpnA:
undetectable		 3mdtB-5jpnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 GLU A 392
SER A 399
GLY A 400
THR A 425
SER A 428
 None
 1.39A 3r75A-5jpnA:
undetectable		 3r75A-5jpnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 GLU A 392
SER A 399
GLY A 400
THR A 425
SER A 428
 None
 1.40A 3r75B-5jpnA:
undetectable		 3r75B-5jpnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
 None
 1.06A 3rr3A-5jpnB:
undetectable		 3rr3A-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
 None
 1.05A 3rr3B-5jpnB:
1.6		 3rr3B-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
LEU B 944
LEU B1378
GLY B 962
 None
 0.91A 3rr3C-5jpnB:
undetectable		 3rr3C-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
 None
 1.06A 3rr3C-5jpnB:
undetectable		 3rr3C-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
LEU B 944
LEU B1378
GLY B 962
 None
 0.90A 3rr3D-5jpnB:
undetectable		 3rr3D-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
 None
 1.06A 3rr3D-5jpnB:
undetectable		 3rr3D-5jpnB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 LYS A 373
SER A 428
GLN A 430
 None
 1.31A 3si7A-5jpnA:
undetectable		 3si7A-5jpnA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 ILE B1307
ILE B1147
SER B1313
LEU B1088
 None
 0.71A 3ua5B-5jpnB:
1.7		 3ua5B-5jpnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 ILE C1472
LEU C1523
LEU C1556
ILE C1485
ALA C1484
 None
 0.99A 3vrmA-5jpnC:
undetectable		 3vrmA-5jpnC:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 6 HIS B 836
GLU C1463
ASN A 240
GLU A 351
 None
 1.16A 3vywA-5jpnB:
undetectable		 3vywA-5jpnB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR C1559
VAL B1306
ILE B1307
TYR B1267
LEU B1078
 None
 0.91A 4a84A-5jpnC:
undetectable		 4a84A-5jpnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 VAL A 282
TYR A 339
ILE A 312
ILE A 245
 None
 0.94A 4afgD-5jpnA:
undetectable
4afgE-5jpnA:
undetectable		 4afgD-5jpnA:
16.93
4afgE-5jpnA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 ALA B1268
ALA B1221
ALA B1190
LEU B1217
 None
A2G  B1508 (-4.5A)
None
None
 0.90A 4du2A-5jpnB:
undetectable		 4du2A-5jpnB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 ALA B1268
ALA B1221
ALA B1190
LEU B1217
 None
A2G  B1508 (-4.5A)
None
None
 0.85A 4du2B-5jpnB:
undetectable		 4du2B-5jpnB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 ASN B1348
ALA B 982
SER B 983
ARG B1291
 None
 1.13A 4ijiF-5jpnB:
5.9		 4ijiF-5jpnB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 ASN B1348
ALA B 982
SER B 983
ARG B1291
 None
 1.15A 4ijiH-5jpnB:
6.0		 4ijiH-5jpnB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLU C1534
SER C1532
ARG B 722
PRO C1530
 None
 1.15A 4k17B-5jpnC:
undetectable		 4k17B-5jpnC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE A 202
MET B1054
ARG A 157
VAL A 233
 None
 1.11A 4mk4B-5jpnA:
undetectable		 4mk4B-5jpnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 SER A 216
MET A 177
ASP A 221
 None
None
PBM  A 704 (-3.6A)
 0.90A 4mm4B-5jpnA:
undetectable		 4mm4B-5jpnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 TYR A 548
PHE A 546
PHE A 654
GLY A  40
 None
 0.98A 4qoiA-5jpnA:
undetectable
4qoiB-5jpnA:
undetectable		 4qoiA-5jpnA:
17.25
4qoiB-5jpnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 9 PHE B1360
SER B1341
VAL B 980
VAL B 978
LEU B1344
 None
 1.42A 4wnvA-5jpnB:
2.0		 4wnvA-5jpnB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 LEU B1217
LEU B1200
ALA B1213
THR B1138
ALA B1199
 None
 1.25A 4x1kA-5jpnB:
undetectable
4x1kB-5jpnB:
undetectable		 4x1kA-5jpnB:
19.87
4x1kB-5jpnB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 7 PHE B1144
ILE B1147
PHE B1081
MET B1015
 None
 0.80A 4zdzA-5jpnB:
undetectable		 4zdzA-5jpnB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 11 LEU B1088
ILE B1307
TYR B1267
ALA B1199
ILE B1195
 None
 1.17A 5d75A-5jpnB:
undetectable		 5d75A-5jpnB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 9 GLY B1293
SER B1294
GLU B 943
ILE B1262
ALA B1308
 None
 1.32A 5entC-5jpnB:
undetectable		 5entC-5jpnB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 GLU B 780
GLY A 602
THR B 805
TRP B 806
 None
 0.93A 5flcB-5jpnB:
undetectable		 5flcB-5jpnB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 8 GLU B 780
GLY A 602
THR B 805
TRP B 806
 None
 0.93A 5flcF-5jpnB:
undetectable		 5flcF-5jpnB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 TYR B1053
SER B1096
GLN B1090
GLY B1152
LEU B1083
 None
 1.38A 5g6sB-5jpnB:
undetectable
5g6sC-5jpnB:
undetectable		 5g6sB-5jpnB:
18.55
5g6sC-5jpnB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 11 LEU B1088
ILE B1307
TYR B1267
ALA B1199
ILE B1195
 None
 1.09A 5gpgA-5jpnB:
undetectable		 5gpgA-5jpnB:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 6 LEU B1132
THR B1234
TRP B1261
GLN B1222
 None
 1.36A 5h8tA-5jpnB:
undetectable		 5h8tA-5jpnB:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 5 TYR C1737
GLY C1738
THR C1739
GLY C1697
 None
 0.62A 5jlcA-5jpnC:
undetectable		 5jlcA-5jpnC:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 LEU A  76
ALA A  83
LEU A  85
PHE A  74
LEU A 510
 None
 1.25A 5ljcA-5jpnA:
undetectable		 5ljcA-5jpnA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		4 / 4 LEU B1273
LEU B1270
SER B1286
ALA B1266
 None
 1.14A 5uunA-5jpnB:
5.8		 5uunA-5jpnB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PHE B1144
THR B1196
GLU B1263
ASN C1561
 None
 1.31A 5ybbA-5jpnB:
undetectable		 5ybbA-5jpnB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		5 / 12 GLY A 471
PRO A 466
GLY A 468
LEU A 473
ASN A 556
 None
 1.39A 5yn6A-5jpnA:
undetectable		 5yn6A-5jpnA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		3 / 3 MET A 352
ASP B 768
ARG B 743
 None
 0.98A 5z6jA-5jpnA:
undetectable		 5z6jA-5jpnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		3 / 3 MET A 352
ASP B 768
ARG B 743
 None
 1.14A 5z6kA-5jpnA:
undetectable		 5z6kA-5jpnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5jpn COMPLEMENT C4-A
(Homo
sapiens) 		3 / 3 TYR B 977
LEU B1362
ASP B 965
 PBM  B1515 ( 4.9A)
None
None
 0.85A 5zv2B-5jpnB:
undetectable		 5zv2B-5jpnB:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO C1573
VAL B1403
GLY B 937
VAL C1549
 None
 1.06A 6ak3B-5jpnC:
undetectable		 6ak3B-5jpnC:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.02A 6mn4C-5jpnB:
undetectable		 6mn4C-5jpnB:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.19A 6mn5D-5jpnB:
undetectable		 6mn5D-5jpnB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.13A 6mn5E-5jpnB:
undetectable		 6mn5E-5jpnB:
8.14