SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 9 LEU s  37
LEU s  33
ILE s  81
LYS s   2
ILE s  63
 None
 1.46A 1hzeA-5jpqs:
undetectable
1hzeB-5jpqs:
undetectable		 1hzeA-5jpqs:
19.80
1hzeB-5jpqs:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 9 ILE s  63
LEU s  37
LEU s  33
ILE s  81
LYS s   2
 None
 1.45A 1hzeA-5jpqs:
undetectable
1hzeB-5jpqs:
undetectable		 1hzeA-5jpqs:
19.80
1hzeB-5jpqs:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jpq ES6
(Chaetomium
thermophilum) 		5 / 10 ILE r 113
ALA r  12
ASN r   4
ILE r   5
THR r  10
 None
None
A  2 162 ( 3.9A)
None
None
 1.28A 1j3jA-5jpqr:
undetectable		 1j3jA-5jpqr:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5jpq ES8
(Chaetomium
thermophilum) 		4 / 7 GLU t 192
GLU t 195
GLU t 197
GLU t 160
 None
 1.13A 1knyA-5jpqt:
undetectable
1knyB-5jpqt:
undetectable		 1knyA-5jpqt:
22.55
1knyB-5jpqt:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5jpq ES6
(Chaetomium
thermophilum) 		5 / 9 LEU r 111
ILE r 101
GLY r 103
VAL r  36
ILE r  52
 None
 0.98A 1ohrB-5jpqr:
undetectable		 1ohrB-5jpqr:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5jpq ES1
(Chaetomium
thermophilum) 		4 / 7 ILE o 195
GLY o 196
PRO o  39
ASN o  78
 None
 0.76A 1oniG-5jpqo:
undetectable
1oniI-5jpqo:
undetectable		 1oniG-5jpqo:
20.97
1oniI-5jpqo:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5jpq ES6
(Chaetomium
thermophilum) 		5 / 12 GLY r  55
ILE r 101
GLY r 103
VAL r  36
ILE r  52
 None
 0.78A 2bpxB-5jpqr:
undetectable		 2bpxB-5jpqr:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5jpq ES8
(Chaetomium
thermophilum) 		4 / 8 LYS t  83
ALA t 186
ARG t 185
LEU t  68
 U  2 259 ( 2.0A)
None
U  2 208 ( 1.6A)
None
 1.00A 2bxkA-5jpqt:
2.9		 2bxkA-5jpqt:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5jpq ES8
(Chaetomium
thermophilum) 		4 / 8 LYS t  83
ALA t 186
ARG t 185
LEU t  68
 U  2 259 ( 2.0A)
None
U  2 208 ( 1.6A)
None
 0.92A 2bxmA-5jpqt:
2.9		 2bxmA-5jpqt:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jpq ES1
(Chaetomium
thermophilum) 		5 / 12 ILE o 187
THR o 101
ALA o  36
PHE o 103
SER o  70
 None
 1.39A 2gl0A-5jpqo:
undetectable
2gl0C-5jpqo:
undetectable		 2gl0A-5jpqo:
22.14
2gl0C-5jpqo:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5jpq ES1
(Chaetomium
thermophilum) 		5 / 12 PHE o 103
SER o  70
ILE o 187
THR o 101
ALA o  36
 None
 1.39A 2gl0D-5jpqo:
undetectable
2gl0E-5jpqo:
undetectable		 2gl0D-5jpqo:
22.14
2gl0E-5jpqo:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5jpq ES8
(Chaetomium
thermophilum) 		5 / 12 LYS t  83
GLU t  70
ILE t  86
ALA t 186
LEU t  68
 U  2 259 ( 2.0A)
None
None
None
None
 1.11A 2plwA-5jpqt:
undetectable		 2plwA-5jpqt:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 11 LEU s  80
LEU s  84
LEU s  88
ILE s  40
VAL s  45
 None
 1.28A 2qd3A-5jpqs:
undetectable		 2qd3A-5jpqs:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jpq ES1
(Chaetomium
thermophilum) 		4 / 6 PRO o  39
ILE o 187
ASN o 193
LEU o 185
 None
 1.38A 2wekB-5jpqo:
undetectable		 2wekB-5jpqo:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5jpq ES8
(Chaetomium
thermophilum) 		5 / 12 ILE t  80
LEU t 159
ILE t 127
ARG t 135
LEU t 129
 None
 1.27A 2zzaA-5jpqt:
undetectable		 2zzaA-5jpqt:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 12 LEU s  80
LEU s  84
LEU s  88
ILE s  40
VAL s  45
 None
 1.30A 4f4dA-5jpqs:
undetectable		 4f4dA-5jpqs:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5jpq ES6
KRE33
(Chaetomium
thermophilum) 		5 / 10 MET r   1
PHE r   3
ALA r  53
LEU r 111
ALA i 932
 None
None
G  2 163 ( 4.3A)
None
None
 1.18A 4fe1A-5jpqr:
5.7
4fe1J-5jpqr:
undetectable		 4fe1A-5jpqr:
15.11
4fe1J-5jpqr:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5jpq ES8
(Chaetomium
thermophilum) 		4 / 7 ASN t 162
GLU t 197
GLU t 195
GLU t 160
 None
 1.33A 4r87I-5jpqt:
undetectable		 4r87I-5jpqt:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5jpq ES6
(Chaetomium
thermophilum) 		4 / 7 MET r   1
PHE r   3
ALA r  53
LEU r 111
 None
None
G  2 163 ( 4.3A)
None
 1.09A 4xk8A-5jpqr:
2.6		 4xk8A-5jpqr:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5jpq ES6
(Chaetomium
thermophilum) 		3 / 3 HIS r  81
SER r  82
LYS r  64
 None
 1.31A 5os7A-5jpqr:
undetectable		 5os7A-5jpqr:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5jpq ES8
(Chaetomium
thermophilum) 		4 / 8 GLY t  30
ILE t   3
ASP t   6
HIS t   9
 U  2 332 ( 4.0A)
None
None
None
 0.88A 6ag0A-5jpqt:
undetectable		 6ag0A-5jpqt:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 9 VAL s  92
VAL s  45
LEU s  84
GLY s  20
LEU s  23
 None
 1.34A 6czmB-5jpqs:
undetectable
6czmC-5jpqs:
undetectable		 6czmB-5jpqs:
18.49
6czmC-5jpqs:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5jpq ES7
(Chaetomium
thermophilum) 		5 / 9 VAL s  92
VAL s  45
LEU s  84
GLY s  20
LEU s  23
 None
 1.32A 6czmD-5jpqs:
undetectable
6czmE-5jpqs:
undetectable		 6czmD-5jpqs:
18.49
6czmE-5jpqs:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5jpq ES6
(Chaetomium
thermophilum) 		3 / 3 HIS r  81
SER r  82
LYS r  64
 None
 1.31A 6gmdB-5jpqr:
undetectable		 6gmdB-5jpqr:
20.16