SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 6 VAL A  20
VAL A  62
ILE A  72
ASN A 279
 None
 0.92A 1e06A-5jqeA:
undetectable		 1e06A-5jqeA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		3 / 3 GLN A 347
TYR A 111
ARG A 110
 None
 0.94A 1gtbA-5jqeA:
undetectable		 1gtbA-5jqeA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 172
VAL A 369
LEU A 210
MET A 216
LEU A 163
 None
 1.43A 1nhzA-5jqeA:
undetectable		 1nhzA-5jqeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 10 LEU A 204
LEU A 207
ILE A 173
GLU A 165
LEU A 163
 None
 1.13A 1wopA-5jqeA:
undetectable		 1wopA-5jqeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 5 ILE A1069
LEU A1140
ALA A1020
GLU A1017
 None
 1.34A 1xvaA-5jqeA:
undetectable
1xvaB-5jqeA:
undetectable		 1xvaA-5jqeA:
18.87
1xvaB-5jqeA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 ILE A 120
LEU A 274
ILE A  71
VAL A  35
LEU A  32
 None
 1.06A 3a51C-5jqeA:
undetectable		 3a51C-5jqeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ATT_A_ACTA1209_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 4 ASP A1018
ARG A1071
ASP A1015
GLU A1017
 None
 1.41A 3attA-5jqeA:
0.2		 3attA-5jqeA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A1059
LEU A1062
LEU A1048
LEU A1022
LEU A1075
 None
 1.27A 3d90B-5jqeA:
undetectable		 3d90B-5jqeA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 VAL A 355
GLY A 199
ALA A 200
LEU A 204
LEU A 172
 None
 1.02A 3hs6A-5jqeA:
undetectable		 3hs6A-5jqeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 VAL A 208
LEU A 172
GLY A 199
ALA A 200
LEU A 373
 None
 0.99A 3n8yB-5jqeA:
undetectable		 3n8yB-5jqeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.11A 3ut5B-5jqeA:
undetectable		 3ut5B-5jqeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 5 GLU A 320
ASP A 326
ASP A 299
ASN A 306
 None
 1.34A 3vywD-5jqeA:
undetectable		 3vywD-5jqeA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 6 GLU A1056
GLU A 371
ASN A 361
ARG A 366
 None
 1.27A 4ntxA-5jqeA:
3.1
4ntxC-5jqeA:
2.0		 4ntxA-5jqeA:
21.73
4ntxC-5jqeA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.03A 4o2bB-5jqeA:
undetectable		 4o2bB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.00A 5eypB-5jqeA:
undetectable		 5eypB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.07A 5itzB-5jqeA:
undetectable		 5itzB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		3 / 3 TYR A1008
TYR A 111
GLN A  84
 None
 1.09A 5jsdA-5jqeA:
undetectable
5jsdB-5jqeA:
undetectable		 5jsdA-5jqeA:
21.45
5jsdB-5jqeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		3 / 3 TYR A1008
TYR A 111
GLN A  84
 None
 1.10A 5jsdB-5jqeA:
undetectable
5jsdC-5jqeA:
undetectable		 5jsdB-5jqeA:
21.45
5jsdC-5jqeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 0.99A 5mioB-5jqeA:
undetectable		 5mioB-5jqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 ASP A1015
LEU A1042
ALA A1041
PHE A1045
LEU A1066
 None
 0.95A 5nd4B-5jqeA:
undetectable		 5nd4B-5jqeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		4 / 8 VAL A 355
GLY A 203
LEU A 207
THR A 205
 None
 1.02A 5sxqB-5jqeA:
undetectable		 5sxqB-5jqeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		6 / 12 ALA A 354
ALA A 350
GLY A 178
ALA A 200
PHE A 181
VAL A 193
 None
 1.41A 5w4zA-5jqeA:
undetectable		 5w4zA-5jqeA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		6 / 12 ALA A 354
ALA A 350
GLY A 178
ALA A 200
PHE A 181
VAL A 193
 None
 1.44A 5w4zB-5jqeA:
undetectable		 5w4zB-5jqeA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
 None
 1.07A 5xiwD-5jqeA:
undetectable		 5xiwD-5jqeA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA
(Escherichia
coli) 		5 / 12 VAL A1112
LEU A1105
LEU A1152
GLY A1123
LEU A1124
 None
 0.97A 6b0cD-5jqeA:
undetectable		 6b0cD-5jqeA:
9.03