SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5jqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 648
ASN A 476
VAL A 478
TYR A 316
GLY A 318
 None
 1.35A 1fkoA-5jqkA:
undetectable		 1fkoA-5jqkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 584
THR A 580
VAL A 582
 None
 0.95A 1hxbA-5jqkA:
undetectable		 1hxbA-5jqkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 GLU A 349
LYS A 470
VAL A 468
 None
 0.78A 1l2iA-5jqkA:
undetectable		 1l2iA-5jqkA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 TYR A 302
ASN A 305
TYR A 361
GLY A 358
 None
 1.13A 1mxgA-5jqkA:
undetectable		 1mxgA-5jqkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 584
THR A 580
VAL A 582
 None
 0.97A 2q64A-5jqkA:
undetectable		 2q64A-5jqkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 584
THR A 580
VAL A 582
 None
 0.94A 2qakA-5jqkA:
undetectable		 2qakA-5jqkA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 LEU A 353
LEU A 328
ILE A 415
VAL A 386
ILE A 385
 None
 1.21A 2uxoB-5jqkA:
undetectable		 2uxoB-5jqkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 495
LEU A 492
LEU A 489
GLN A 485
LEU A 747
 None
 1.15A 3d90B-5jqkA:
undetectable		 3d90B-5jqkA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASN A 243
ASP A 157
ASP A 168
SER A 445
TYR A 412
 None
 1.39A 3havC-5jqkA:
undetectable		 3havC-5jqkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ILE A 452
SER A 445
SER A 443
 None
 0.63A 3iltH-5jqkA:
undetectable		 3iltH-5jqkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 PHE A 248
PHE A 239
GLY A 182
PHE A 289
 None
 1.13A 3ko0R-5jqkA:
undetectable
3ko0T-5jqkA:
undetectable		 3ko0R-5jqkA:
11.43
3ko0T-5jqkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 GLU A 731
GLU A 629
ASN A 630
 None
 0.54A 3lp9B-5jqkA:
undetectable
3lp9D-5jqkA:
undetectable		 3lp9B-5jqkA:
17.14
3lp9D-5jqkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 TYR A 418
GLU A 413
TYR A 412
 None
 0.93A 3ug8A-5jqkA:
undetectable		 3ug8A-5jqkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ASP A 381
ILE A 385
VAL A 407
ASN A 355
LEU A 328
 None
 0.99A 4a81A-5jqkA:
undetectable		 4a81A-5jqkA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 569
PHE A 532
VAL A 522
ASP A 490
GLN A 574
 None
 1.41A 4c9wA-5jqkA:
undetectable		 4c9wA-5jqkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 TYR A 717
HIS A 606
ARG A 584
 None
 1.17A 4e7bC-5jqkA:
undetectable		 4e7bC-5jqkA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ARG A 597
GLU A 594
PHE A 685
 None
 0.93A 4kszA-5jqkA:
undetectable		 4kszA-5jqkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 ILE A 448
LEU A 444
GLU A 346
VAL A 468
 None
 1.05A 4nkxB-5jqkA:
undetectable		 4nkxB-5jqkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ASP A 570
ASP A 581
ASN A 675
 MN  A 802 ( 1.9A)
MN  A 802 (-2.2A)
None
 0.69A 4q5mA-5jqkA:
undetectable		 4q5mA-5jqkA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ILE A 448
PHE A 456
LEU A 444
LEU A 419
 None
 0.95A 4qopC-5jqkA:
undetectable		 4qopC-5jqkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 MET A 714
ASP A 710
PHE A 709
 None
 0.95A 4xeyA-5jqkA:
undetectable		 4xeyA-5jqkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 MET A 714
ASP A 710
PHE A 709
 None
 0.92A 4xeyB-5jqkA:
undetectable		 4xeyB-5jqkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 4 ILE A 768
ARG A 505
TYR A 764
GLU A 502
 None
 1.08A 4zzbD-5jqkA:
undetectable		 4zzbD-5jqkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 ILE A 768
ARG A 505
TYR A 764
GLU A 502
 None
 1.10A 4zzcE-5jqkA:
undetectable		 4zzcE-5jqkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 LEU A 354
SER A 369
PHE A 388
GLU A 414
 None
 1.21A 5b8iA-5jqkA:
undetectable		 5b8iA-5jqkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 366
PHE A 367
LEU A 347
ILE A 452
LEU A 343
 None
 1.20A 5ienB-5jqkA:
1.2		 5ienB-5jqkA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 TYR A 151
LEU A 153
GLY A 241
MET A 451
TYR A 271
 None
 1.22A 5ifuA-5jqkA:
undetectable		 5ifuA-5jqkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 TYR A 567
ILE A 566
PHE A 498
GLY A 589
LEU A 510
 None
 1.41A 5v5zA-5jqkA:
undetectable		 5v5zA-5jqkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 GLY A 686
LEU A 518
ILE A 540
LEU A 569
THR A 585
 None
 0.98A 5vm8B-5jqkA:
undetectable		 5vm8B-5jqkA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.13A 5xdhA-5jqkA:
undetectable
5xdhC-5jqkA:
undetectable		 5xdhA-5jqkA:
8.57
5xdhC-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.01A 5xdhB-5jqkA:
undetectable		 5xdhB-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.12A 5xdhA-5jqkA:
undetectable
5xdhC-5jqkA:
undetectable		 5xdhA-5jqkA:
8.57
5xdhC-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 MET A 671
ASN A 651
VAL A 646
LEU A 673
 None
 1.10A 5xdhD-5jqkA:
undetectable		 5xdhD-5jqkA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5jqk PEPTIDASE, PUTATIVE
(Plasmodium
falciparum) 		4 / 5 LEU A 328
VAL A 468
GLU A 349
LEU A 344
 None
 1.07A 5xooB-5jqkA:
undetectable		 5xooB-5jqkA:
12.61